Overview
| Uniprot ID | Q13422 |
|---|
| Protein Name | DNA-binding protein Ikaros |
|---|
| Gene Name | IKZF1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 281 |
RKSSMPQKFLGDKGL |
| 378 |
ENLLLLSKAKLVPSE |
Function
Transcription regulator of hematopoietic cell differentiation (PubMed:17934067). Binds gamma-satellite DNA (PubMed:17135265, PubMed:19141594). Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs) (By similarity). Function is isoform-specific and is modulated by dominant-negative inactive isoforms (PubMed:17135265, PubMed:17934067)
Protein Sequence
10
MDADEGQDMS
20
QVSGKESPPV
30
SDTPDEGDEP
40
MPIPEDLSTT
50
SGGQQSSKSD
60
RVVASNVKVE
70
TQSDEENGRA
80
CEMNGEECAE
90
DLRMLDASGE
100
KMNGSHRDQG
110
SSALSGVGGI
120
RLPNGKLKCD
130
ICGIICIGPN
140
VLMVHKRSHT
150
GERPFQCNQC
160
GASFTQKGNL
170
LRHIKLHSGE
180
KPFKCHLCNY
190
ACRRRDALTG
200
HLRTHSVGKP
210
HKCGYCGRSY
220
KQRSSLEEHK
230
ERCHNYLESM
240
GLPGTLYPVI
250
KEETNHSEMA
260
EDLCKIGSER
270
SLVLDRLASN
280
VAKRKSSMPQ
290
KFLGDKGLSD
300
TPYDSSASYE
310
KENEMMKSHV
320
MDQAINNAIN
330
YLGAESLRPL
340
VQTPPGGSEV
350
VPVISPMYQL
360
HKPLAEGTPR
370
SNHSAQDSAV
380
ENLLLLSKAK
390
LVPSEREASP
400
SNSCQDSTDT
410
ESNNEEQRSG
420
LIYLTNHIAP
430
HARNGLSLKE
440
EHRAYDLLRA
450
ASENSQDALR
460
VVSTSGEQMK
470
VYKCEHCRVL
480
FLDHVMYTIH
490
MGCHGFRDPF
500
ECNMCGYHSQ
510
DRYEFSSHIT
RGEHRFHMS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0005721 |
pericentric heterochromatin |
| Cellular Component |
GO:0032991 |
protein-containing complex |
| Molecular Function |
GO:0003677 |
DNA binding |
| Molecular Function |
GO:0003700 |
DNA-binding transcription factor activity |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0019904 |
protein domain specific binding |
| Molecular Function |
GO:0000978 |
RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function |
GO:0008270 |
zinc ion binding |
| Biological Process |
GO:0006325 |
chromatin organization |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
| Biological Process |
GO:0030218 |
erythrocyte differentiation |
| Biological Process |
GO:0030098 |
lymphocyte differentiation |
| Biological Process |
GO:0007498 |
mesoderm development |
| Biological Process |
GO:0045892 |
negative regulation of DNA-templated transcription |
| Biological Process |
GO:0006357 |
regulation of transcription by RNA polymerase II |
Reference
[1] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.