Search Results
Overview
| Uniprot ID | Q13424 |
|---|---|
| Protein Name | Alpha-1-syntrophin |
| Gene Name | SNTA1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 355 | LVHSGPSKGSVPYDA |
Function
Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the extracellular matrix via the dystrophin glycoprotein complex. Plays an important role in synapse formation and in the organization of UTRN and acetylcholine receptors at the neuromuscular synapse. Binds to phosphatidylinositol 4,5-bisphosphate (By similarity)
Protein Sequence
10
MASGRRAPRT
20
GLLELRAGAG
30
SGAGGERWQR
40
VLLSLAEDVL
50
TVSPADGDPG
60
PEPGAPREQE
70
PAQLNGAAEP
80
GAGPPQLPEA
90
LLLQRRRVTV
100
RKADAGGLGI
110
SIKGGRENKM
120
PILISKIFKG
130
LAADQTEALF
140
VGDAILSVNG
150
EDLSSATHDE
160
AVQVLKKTGK
170
EVVLEVKYMK
180
DVSPYFKNST
190
GGTSVGWDSP
200
PASPLQRQPS
210
SPGPTPRNFS
220
EAKHMSLKMA
230
YVSKRCTPND
240
PEPRYLEICS
250
ADGQDTLFLR
260
AKDEASARSW
270
ATAIQAQVNT
280
LTPRVKDELQ
290
ALLAATSTAG
300
SQDIKQIGWL
310
TEQLPSGGTA
320
PTLALLTEKE
330
LLLYLSLPET
340
REALSRPART
350
APLIATRLVH
360
SGPSKGSVPY
370
DAELSFALRT
380
GTRHGVDTHL
390
FSVESPQELA
400
AWTRQLVDGC
410
HRAAEGVQEV
420
STACTWNGRP
430
CSLSVHIDKG
440
FTLWAAEPGA
450
ARAVLLRQPF
460
EKLQMSSDDG
470
ASLLFLDFGG
480
AEGEIQLDLH
490
SCPKTIVFII
500
HSFLSAKVTR
LGLLA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0070161 | anchoring junction |
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0016010 | dystrophin-associated glycoprotein complex |
| Cellular Component | GO:0031594 | neuromuscular junction |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:0042383 | sarcolemma |
| Cellular Component | GO:0016013 | syntrophin complex |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:0051117 | ATPase binding |
| Molecular Function | GO:0005516 | calmodulin binding |
| Molecular Function | GO:0002162 | dystroglycan binding |
| Molecular Function | GO:0060090 | molecular adaptor activity |
| Molecular Function | GO:0050998 | nitric-oxide synthase binding |
| Molecular Function | GO:0030165 | PDZ domain binding |
| Molecular Function | GO:0017080 | sodium channel regulator activity |
| Molecular Function | GO:0005198 | structural molecule activity |
| Molecular Function | GO:0044325 | transmembrane transporter binding |
| Biological Process | GO:0043010 | camera-type eye development |
| Biological Process | GO:0006936 | muscle contraction |
| Biological Process | GO:0035022 | positive regulation of Rac protein signal transduction |
| Biological Process | GO:0002027 | regulation of heart rate |
| Biological Process | GO:1902305 | regulation of sodium ion transmembrane transport |
| Biological Process | GO:0060307 | regulation of ventricular cardiac muscle cell membrane repolarization |
| Biological Process | GO:0099536 | synaptic signaling |
| Biological Process | GO:0086005 | ventricular cardiac muscle cell action potential |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.