Search Results

Overview

Uniprot ID	Q13451
Protein Name	Peptidyl-prolyl cis-trans isomerase FKBP5
Gene Name	FKBP5
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
385	LEVNPQNKAARLQIS
415	IYANMFKKFAEQDAK
432	ANKAMGKKTSEGVTN
58	DKVYVHYKGKLSNGK
60	VYVHYKGKLSNGKKF

Function

Immunophilin protein with PPIase and co-chaperone activities (PubMed:11350175). Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded (PubMed:12538866). Acts as a regulator of Akt/AKT1 activity by promoting the interaction between Akt/AKT1 and PHLPP1, thereby enhancing dephosphorylation and subsequent activation of Akt/AKT1 (PubMed:28147277, PubMed:28363942). Interacts with IKBKE and IKBKB which facilitates IKK complex assembly leading to increased IKBKE and IKBKB kinase activity, NF-kappa-B activation, and IFN production (PubMed:26101251, PubMed:31434731)

Protein Sequence

10 MTTDEGAKNN 20 EESPTATVAE 30 QGEDITSKKD 40 RGVLKIVKRV 50 GNGEETPMIG 60 DKVYVHYKGK 70 LSNGKKFDSS 80 HDRNEPFVFS 90 LGKGQVIKAW 100 DIGVATMKKG 110 EICHLLCKPE 120 YAYGSAGSLP 130 KIPSNATLFF 140 EIELLDFKGE 150 DLFEDGGIIR 160 RTKRKGEGYS 170 NPNEGATVEI 180 HLEGRCGGRM 190 FDCRDVAFTV 200 GEGEDHDIPI 210 GIDKALEKMQ 220 REEQCILYLG 230 PRYGFGEAGK 240 PKFGIEPNAE 250 LIYEVTLKSF 260 EKAKESWEMD 270 TKEKLEQAAI 280 VKEKGTVYFK 290 GGKYMQAVIQ 300 YGKIVSWLEM 310 EYGLSEKESK 320 ASESFLLAAF 330 LNLAMCYLKL 340 REYTKAVECC 350 DKALGLDSAN 360 EKGLYRRGEA 370 QLLMNEFESA 380 KGDFEKVLEV 390 NPQNKAARLQ 400 ISMCQKKAKE 410 HNERDRRIYA 420 NMFKKFAEQD 430 AKEEANKAMG 440 KKTSEGVTNE 450 KGTDSQAMEE EKPEGHV

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0005528	FK506 binding
Molecular Function	GO:0031072	heat shock protein binding
Molecular Function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity
Molecular Function	GO:0030674	protein-macromolecule adaptor activity
Biological Process	GO:0051898	negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Biological Process	GO:0006457	protein folding
Biological Process	GO:0097305	response to alcohol
Biological Process	GO:0042220	response to cocaine

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[4] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.