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Overview

Uniprot IDQ13459
Protein NameUnconventional myosin-IXb
Gene NameMYO9B
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
935 KRNYQIGKTKVFLKE
937 NYQIGKTKVFLKETE

Function

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions (PubMed:9490638). Also acts as a GTPase activator for RHOA (PubMed:26529257, PubMed:9490638). Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257)

Protein Sequence

10 MSVKEAGSSG 20 RREQAAYHLH 30 IYPQLSTTES 40 QASCRVTATK 50 DSTTSDVIKD 60 AIASLRLDGT 70 KCYVLVEVKE 80 SGGEEWVLDA 90 NDSPVHRVLL 100 WPRRAQDEHP 110 QEDGYYFLLQ 120 ERNADGTIKY 130 VHMQLVAQAT 140 ATRRLVERGL 150 LPRQQADFDD 160 LCNLPELTEG 170 NLLKNLKHRF 180 LQQKIYTYAG 190 SILVAINPFK 200 FLPIYNPKYV 210 KMYENQQLGK 220 LEPHVFALAD 230 VAYYTMLRKR 240 VNQCIVISGE 250 SGSGKTQSTN 260 FLIHCLTALS 270 QKGYASGVER 280 TILGAGPVLE 290 AFGNAKTAHN 300 NNSSRFGKFI 310 QVSYLESGIV 320 RGAVVEKYLL 330 EKSRLVSQEK 340 DERNYHVFYY 350 LLLGVSEEER 360 QEFQLKQPED 370 YFYLNQHNLK 380 IEDGEDLKHD 390 FERLKQAMEM 400 VGFLPATKKQ 410 IFAVLSAILY 420 LGNVTYKKRA 430 TGREEGLEVG 440 PPEVLDTLSQ 450 LLKVKREILV 460 EVLTKRKTVT 470 VNDKLILPYS 480 LSEAITARDS 490 MAKSLYSALF 500 DWIVLRINHA 510 LLNKKDVEEA 520 VSCLSIGVLD 530 IFGFEDFERN 540 SFEQFCINYA 550 NEQLQYYFNQ 560 HIFKLEQEEY 570 QGEGITWHNI 580 GYTDNVGCIH 590 LISKKPTGLF 600 YLLDEESNFP 610 HATSQTLLAK 620 FKQQHEDNKY 630 FLGTPVMEPA 640 FIIQHFAGKV 650 KYQIKDFREK 660 NMDYMRPDIV 670 ALLRGSDSSY 680 VRELIGMDPV 690 AVFRWAVLRA 700 AIRAMAVLRE 710 AGRLRAERAE 720 KAAGMSSPGA 730 QSHPEELPRG 740 ASTPSEKLYR 750 DLHNQMIKSI 760 KGLPWQGEDP 770 RSLLQSLSRL 780 QKPRAFILKS 790 KGIKQKQIIP 800 KNLLDSKSLK 810 LIISMTLHDR 820 TTKSLLHLHK 830 KKKPPSISAQ 840 FQTSLNKLLE 850 ALGKAEPFFI 860 RCIRSNAEKK 870 ELCFDDELVL 880 QQLRYTGMLE 890 TVRIRRSGYS 900 AKYTFQDFTE 910 QFQVLLPKDA 920 QPCREVISTL 930 LEKMKIDKRN 940 YQIGKTKVFL 950 KETERQALQE 960 TLHREVVRKI 970 LLLQSWFRMV 980 LERRHFLQMK 990 RAAVTIQACW 1000 RSYRVRRALE 1010 RTQAAVYLQA 1020 SWRGYWQRKL 1030 YRHQKQSIIR 1040 LQSLCRGHLQ 1050 RKSFSQMISE 1060 KQKAEEKERE 1070 ALEAARAGAE 1080 EGGQGQAAGG 1090 QQVAEQGPEP 1100 AEDGGHLASE 1110 PEVQPSDRSP 1120 LEHSSPEKEA 1130 PSPEKTLPPQ 1140 KTVAAESHEK 1150 VPSSREKRES 1160 RRQRGLEHVK 1170 FQNKHIQSCK 1180 EESALREPSR 1190 RVTQEQGVSL 1200 LEDKKESRED 1210 ETLLVVETEA 1220 ENTSQKQPTE 1230 QPQAMAVGKV 1240 SEETEKTLPS 1250 GSPRPGQLER 1260 PTSLALDSRV 1270 SPPAPGSAPE 1280 TPEDKSKPCG 1290 SPRVQEKPDS 1300 PGGSTQIQRY 1310 LDAERLASAV 1320 ELWRGKKLVA 1330 AASPSAMLSQ 1340 SLDLSDRHRA 1350 TGAALTPTEE 1360 RRTSFSTSDV 1370 SKLLPSLAKA 1380 QPAAETTDGE 1390 RSAKKPAVQK 1400 KKPGDASSLP 1410 DAGLSPGSQV 1420 DSKSTFKRLF 1430 LHKTKDKKYS 1440 LEGAEELENA 1450 VSGHVVLEAT 1460 TMKKGLEAPS 1470 GQQHRHAAGE 1480 KRTKEPGGKG 1490 KKNRNVKIGK 1500 ITVSEKWRES 1510 VFRQITNANE 1520 LKYLDEFLLN 1530 KINDLRSQKT 1540 PIESLFIEAT 1550 EKFRSNIKTM 1560 YSVPNGKIHV 1570 GYKDLMENYQ 1580 IVVSNLATER 1590 GQKDTNLVLN 1600 LFQSLLDEFT 1610 RGYTKNDFEP 1620 VKQSKAQKKK 1630 RKQERAVQEH 1640 NGHVFASYQV 1650 SIPQSCEQCL 1660 SYIWLMDKAL 1670 LCSVCKMTCH 1680 KKCVHKIQSH 1690 CSYTYGRKGE 1700 PGVEPGHFGV 1710 CVDSLTSDKA 1720 SVPIVLEKLL 1730 EHVEMHGLYT 1740 EGLYRKSGAA 1750 NRTRELRQAL 1760 QTDPAAVKLE 1770 NFPIHAITGV 1780 LKQWLRELPE 1790 PLMTFAQYGD 1800 FLRAVELPEK 1810 QEQLAAIYAV 1820 LEHLPEANHN 1830 SLERLIFHLV 1840 KVALLEDVNR 1850 MSPGALAIIF 1860 APCLLRCPDN 1870 SDPLTSMKDV 1880 LKITTCVEML 1890 IKEQMRKYKV 1900 KMEEISQLEA 1910 AESIAFRRLS 1920 LLRQNAPWPL 1930 KLGFSSPYEG 1940 VLNKSPKTRD 1950 IQEEELEVLL 1960 EEEAAGGDED 1970 REKEILIERI 1980 QSIKEEKEDI 1990 TYRLPELDPR 2000 GSDEENLDSE 2010 TSASTESLLE 2020 ERAGRGASEG 2030 PPAPALPCPG 2040 APTPSPLPTV 2050 AAPPRRRPSS 2060 FVTVRVKTPR 2070 RTPIMPTANI 2080 KLPPGLPSHL 2090 PRWAPGAREA 2100 AAPVRRREPP 2110 ARRPDQIHSV 2120 YITPGADLPV 2130 QGALEPLEED 2140 GQPPGAKRRY 2150 SDPPTYCLPP ASGQTNG

Gene Ontology

Classification GO ID Description
Cellular Component GO:0015629 actin cytoskeleton
Cellular Component GO:0005884 actin filament
Cellular Component GO:0005938 cell cortex
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0030027 lamellipodium
Cellular Component GO:0016020 membrane
Cellular Component GO:0016459 myosin complex
Cellular Component GO:0048471 perinuclear region of cytoplasm
Cellular Component GO:0098871 postsynaptic actin cytoskeleton
Cellular Component GO:0001726 ruffle
Molecular Function GO:0003779 actin binding
Molecular Function GO:0051015 actin filament binding
Molecular Function GO:0043531 ADP binding
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0005516 calmodulin binding
Molecular Function GO:0005096 GTPase activator activity
Molecular Function GO:0000146 microfilament motor activity
Molecular Function GO:0048495 Roundabout binding
Molecular Function GO:0031267 small GTPase binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0030048 actin filament-based movement
Biological Process GO:0072673 lamellipodium morphogenesis
Biological Process GO:0035023 regulation of Rho protein signal transduction
Biological Process GO:0051056 regulation of small GTPase mediated signal transduction
Biological Process GO:0007266 Rho protein signal transduction
Biological Process GO:0035385 Roundabout signaling pathway

Reference

[1] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.