Overview
| Uniprot ID | Q13459 |
| Protein Name | Unconventional myosin-IXb |
| Gene Name | MYO9B |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 935 |
KRNYQIGKTKVFLKE |
| 937 |
NYQIGKTKVFLKETE |
Function
Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions (PubMed:9490638). Also acts as a GTPase activator for RHOA (PubMed:26529257, PubMed:9490638). Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257)
Protein Sequence
10
MSVKEAGSSG
20
RREQAAYHLH
30
IYPQLSTTES
40
QASCRVTATK
50
DSTTSDVIKD
60
AIASLRLDGT
70
KCYVLVEVKE
80
SGGEEWVLDA
90
NDSPVHRVLL
100
WPRRAQDEHP
110
QEDGYYFLLQ
120
ERNADGTIKY
130
VHMQLVAQAT
140
ATRRLVERGL
150
LPRQQADFDD
160
LCNLPELTEG
170
NLLKNLKHRF
180
LQQKIYTYAG
190
SILVAINPFK
200
FLPIYNPKYV
210
KMYENQQLGK
220
LEPHVFALAD
230
VAYYTMLRKR
240
VNQCIVISGE
250
SGSGKTQSTN
260
FLIHCLTALS
270
QKGYASGVER
280
TILGAGPVLE
290
AFGNAKTAHN
300
NNSSRFGKFI
310
QVSYLESGIV
320
RGAVVEKYLL
330
EKSRLVSQEK
340
DERNYHVFYY
350
LLLGVSEEER
360
QEFQLKQPED
370
YFYLNQHNLK
380
IEDGEDLKHD
390
FERLKQAMEM
400
VGFLPATKKQ
410
IFAVLSAILY
420
LGNVTYKKRA
430
TGREEGLEVG
440
PPEVLDTLSQ
450
LLKVKREILV
460
EVLTKRKTVT
470
VNDKLILPYS
480
LSEAITARDS
490
MAKSLYSALF
500
DWIVLRINHA
510
LLNKKDVEEA
520
VSCLSIGVLD
530
IFGFEDFERN
540
SFEQFCINYA
550
NEQLQYYFNQ
560
HIFKLEQEEY
570
QGEGITWHNI
580
GYTDNVGCIH
590
LISKKPTGLF
600
YLLDEESNFP
610
HATSQTLLAK
620
FKQQHEDNKY
630
FLGTPVMEPA
640
FIIQHFAGKV
650
KYQIKDFREK
660
NMDYMRPDIV
670
ALLRGSDSSY
680
VRELIGMDPV
690
AVFRWAVLRA
700
AIRAMAVLRE
710
AGRLRAERAE
720
KAAGMSSPGA
730
QSHPEELPRG
740
ASTPSEKLYR
750
DLHNQMIKSI
760
KGLPWQGEDP
770
RSLLQSLSRL
780
QKPRAFILKS
790
KGIKQKQIIP
800
KNLLDSKSLK
810
LIISMTLHDR
820
TTKSLLHLHK
830
KKKPPSISAQ
840
FQTSLNKLLE
850
ALGKAEPFFI
860
RCIRSNAEKK
870
ELCFDDELVL
880
QQLRYTGMLE
890
TVRIRRSGYS
900
AKYTFQDFTE
910
QFQVLLPKDA
920
QPCREVISTL
930
LEKMKIDKRN
940
YQIGKTKVFL
950
KETERQALQE
960
TLHREVVRKI
970
LLLQSWFRMV
980
LERRHFLQMK
990
RAAVTIQACW
1000
RSYRVRRALE
1010
RTQAAVYLQA
1020
SWRGYWQRKL
1030
YRHQKQSIIR
1040
LQSLCRGHLQ
1050
RKSFSQMISE
1060
KQKAEEKERE
1070
ALEAARAGAE
1080
EGGQGQAAGG
1090
QQVAEQGPEP
1100
AEDGGHLASE
1110
PEVQPSDRSP
1120
LEHSSPEKEA
1130
PSPEKTLPPQ
1140
KTVAAESHEK
1150
VPSSREKRES
1160
RRQRGLEHVK
1170
FQNKHIQSCK
1180
EESALREPSR
1190
RVTQEQGVSL
1200
LEDKKESRED
1210
ETLLVVETEA
1220
ENTSQKQPTE
1230
QPQAMAVGKV
1240
SEETEKTLPS
1250
GSPRPGQLER
1260
PTSLALDSRV
1270
SPPAPGSAPE
1280
TPEDKSKPCG
1290
SPRVQEKPDS
1300
PGGSTQIQRY
1310
LDAERLASAV
1320
ELWRGKKLVA
1330
AASPSAMLSQ
1340
SLDLSDRHRA
1350
TGAALTPTEE
1360
RRTSFSTSDV
1370
SKLLPSLAKA
1380
QPAAETTDGE
1390
RSAKKPAVQK
1400
KKPGDASSLP
1410
DAGLSPGSQV
1420
DSKSTFKRLF
1430
LHKTKDKKYS
1440
LEGAEELENA
1450
VSGHVVLEAT
1460
TMKKGLEAPS
1470
GQQHRHAAGE
1480
KRTKEPGGKG
1490
KKNRNVKIGK
1500
ITVSEKWRES
1510
VFRQITNANE
1520
LKYLDEFLLN
1530
KINDLRSQKT
1540
PIESLFIEAT
1550
EKFRSNIKTM
1560
YSVPNGKIHV
1570
GYKDLMENYQ
1580
IVVSNLATER
1590
GQKDTNLVLN
1600
LFQSLLDEFT
1610
RGYTKNDFEP
1620
VKQSKAQKKK
1630
RKQERAVQEH
1640
NGHVFASYQV
1650
SIPQSCEQCL
1660
SYIWLMDKAL
1670
LCSVCKMTCH
1680
KKCVHKIQSH
1690
CSYTYGRKGE
1700
PGVEPGHFGV
1710
CVDSLTSDKA
1720
SVPIVLEKLL
1730
EHVEMHGLYT
1740
EGLYRKSGAA
1750
NRTRELRQAL
1760
QTDPAAVKLE
1770
NFPIHAITGV
1780
LKQWLRELPE
1790
PLMTFAQYGD
1800
FLRAVELPEK
1810
QEQLAAIYAV
1820
LEHLPEANHN
1830
SLERLIFHLV
1840
KVALLEDVNR
1850
MSPGALAIIF
1860
APCLLRCPDN
1870
SDPLTSMKDV
1880
LKITTCVEML
1890
IKEQMRKYKV
1900
KMEEISQLEA
1910
AESIAFRRLS
1920
LLRQNAPWPL
1930
KLGFSSPYEG
1940
VLNKSPKTRD
1950
IQEEELEVLL
1960
EEEAAGGDED
1970
REKEILIERI
1980
QSIKEEKEDI
1990
TYRLPELDPR
2000
GSDEENLDSE
2010
TSASTESLLE
2020
ERAGRGASEG
2030
PPAPALPCPG
2040
APTPSPLPTV
2050
AAPPRRRPSS
2060
FVTVRVKTPR
2070
RTPIMPTANI
2080
KLPPGLPSHL
2090
PRWAPGAREA
2100
AAPVRRREPP
2110
ARRPDQIHSV
2120
YITPGADLPV
2130
QGALEPLEED
2140
GQPPGAKRRY
2150
SDPPTYCLPP
ASGQTNG
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0015629 |
actin cytoskeleton |
| Cellular Component |
GO:0005884 |
actin filament |
| Cellular Component |
GO:0005938 |
cell cortex |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0030027 |
lamellipodium |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0016459 |
myosin complex |
| Cellular Component |
GO:0048471 |
perinuclear region of cytoplasm |
| Cellular Component |
GO:0098871 |
postsynaptic actin cytoskeleton |
| Cellular Component |
GO:0001726 |
ruffle |
| Molecular Function |
GO:0003779 |
actin binding |
| Molecular Function |
GO:0051015 |
actin filament binding |
| Molecular Function |
GO:0043531 |
ADP binding |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0016887 |
ATP hydrolysis activity |
| Molecular Function |
GO:0005516 |
calmodulin binding |
| Molecular Function |
GO:0005096 |
GTPase activator activity |
| Molecular Function |
GO:0000146 |
microfilament motor activity |
| Molecular Function |
GO:0048495 |
Roundabout binding |
| Molecular Function |
GO:0031267 |
small GTPase binding |
| Molecular Function |
GO:0008270 |
zinc ion binding |
| Biological Process |
GO:0030048 |
actin filament-based movement |
| Biological Process |
GO:0072673 |
lamellipodium morphogenesis |
| Biological Process |
GO:0035023 |
regulation of Rho protein signal transduction |
| Biological Process |
GO:0051056 |
regulation of small GTPase mediated signal transduction |
| Biological Process |
GO:0007266 |
Rho protein signal transduction |
| Biological Process |
GO:0035385 |
Roundabout signaling pathway |
Reference
[1] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.