Search Results

Overview

Uniprot IDQ13469
Protein NameNuclear factor of activated T-cells, cytoplasmic 2
Gene NameNFATC2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
482 QVHRITGKTVTTTSY

Function

Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF or GM-CSF (PubMed:15790681). Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway (PubMed:21871017). Is involved in the negative regulation of chondrogenesis (PubMed:35789258). Recruited by AKAP5 to ORAI1 pore-forming subunit of CRAC channels in Ca(2+) signaling microdomains where store-operated Ca(2+) influx is coupled to calmodulin and calcineurin signaling and activation of NFAT-dependent transcriptional responses

Protein Sequence

10 MNAPERQPQP 20 DGGDAPGHEP 30 GGSPQDELDF 40 SILFDYEYLN 50 PNEEEPNAHK 60 VASPPSGPAY 70 PDDVLDYGLK 80 PYSPLASLSG 90 EPPGRFGEPD 100 RVGPQKFLSA 110 AKPAGASGLS 120 PRIEITPSHE 130 LIQAVGPLRM 140 RDAGLLVEQP 150 PLAGVAASPR 160 FTLPVPGFEG 170 YREPLCLSPA 180 SSGSSASFIS 190 DTFSPYTSPC 200 VSPNNGGPDD 210 LCPQFQNIPA 220 HYSPRTSPIM 230 SPRTSLAEDS 240 CLGRHSPVPR 250 PASRSSSPGA 260 KRRHSCAEAL 270 VALPPGASPQ 280 RSRSPSPQPS 290 SHVAPQDHGS 300 PAGYPPVAGS 310 AVIMDALNSL 320 ATDSPCGIPP 330 KMWKTSPDPS 340 PVSAAPSKAG 350 LPRHIYPAVE 360 FLGPCEQGER 370 RNSAPESILL 380 VPPTWPKPLV 390 PAIPICSIPV 400 TASLPPLEWP 410 LSSQSGSYEL 420 RIEVQPKPHH 430 RAHYETEGSR 440 GAVKAPTGGH 450 PVVQLHGYME 460 NKPLGLQIFI 470 GTADERILKP 480 HAFYQVHRIT 490 GKTVTTTSYE 500 KIVGNTKVLE 510 IPLEPKNNMR 520 ATIDCAGILK 530 LRNADIELRK 540 GETDIGRKNT 550 RVRLVFRVHI 560 PESSGRIVSL 570 QTASNPIECS 580 QRSAHELPMV 590 ERQDTDSCLV 600 YGGQQMILTG 610 QNFTSESKVV 620 FTEKTTDGQQ 630 IWEMEATVDK 640 DKSQPNMLFV 650 EIPEYRNKHI 660 RTPVKVNFYV 670 INGKRKRSQP 680 QHFTYHPVPA 690 IKTEPTDEYD 700 PTLICSPTHG 710 GLGSQPYYPQ 720 HPMVAESPSC 730 LVATMAPCQQ 740 FRTGLSSPDA 750 RYQQQNPAAV 760 LYQRSKSLSP 770 SLLGYQQPAL 780 MAAPLSLADA 790 HRSVLVHAGS 800 QGQSSALLHP 810 SPTNQQASPV 820 IHYSPTNQQL 830 RCGSHQEFQH 840 IMYCENFAPG 850 TTRPGPPPVS 860 QGQRLSPGSY 870 PTVIQQQNAT 880 SQRAAKNGPP 890 VSDQKEVLPA 900 GVTIKQEQNL 910 DQTYLDDVNE 920 IIRKEFSGPP ARNQT

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:1990904 ribonucleoprotein complex
Cellular Component GO:0005667 transcription regulator complex
Molecular Function GO:0071889 14-3-3 protein binding
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
Molecular Function GO:0003700 DNA-binding transcription factor activity
Molecular Function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular Function GO:0060090 molecular adaptor activity
Molecular Function GO:0019902 phosphatase binding
Molecular Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function GO:1990837 sequence-specific double-stranded DNA binding
Biological Process GO:0050853 B cell receptor signaling pathway
Biological Process GO:0033173 calcineurin-NFAT signaling cascade
Biological Process GO:0051216 cartilage development
Biological Process GO:0016477 cell migration
Biological Process GO:0006974 DNA damage response
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:1905064 negative regulation of vascular associated smooth muscle cell differentiation
Biological Process GO:0030890 positive regulation of B cell proliferation
Biological Process GO:0045893 positive regulation of DNA-templated transcription
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0006355 regulation of DNA-templated transcription
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:0009410 response to xenobiotic stimulus

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.