Search Results

Overview

Uniprot ID	Q13478
Protein Name	Interleukin-18 receptor 1
Gene Name	IL18R1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
445	RLIIVLSKSYMSNEV

Function

Within the IL18 receptor complex, responsible for the binding of the pro-inflammatory cytokine IL18, but not IL1A nor IL1B (PubMed:14528293, PubMed:25261253, PubMed:25500532, PubMed:37993714, PubMed:8626725). Involved in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (PubMed:10653850). Contributes to IL18-induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3 (By similarity)

Protein Sequence

10 MNCRELPLTL 20 WVLISVSTAE 30 SCTSRPHITV 40 VEGEPFYLKH 50 CSCSLAHEIE 60 TTTKSWYKSS 70 GSQEHVELNP 80 RSSSRIALHD 90 CVLEFWPVEL 100 NDTGSYFFQM 110 KNYTQKWKLN 120 VIRRNKHSCF 130 TERQVTSKIV 140 EVKKFFQITC 150 ENSYYQTLVN 160 STSLYKNCKK 170 LLLENNKNPT 180 IKKNAEFEDQ 190 GYYSCVHFLH 200 HNGKLFNITK 210 TFNITIVEDR 220 SNIVPVLLGP 230 KLNHVAVELG 240 KNVRLNCSAL 250 LNEEDVIYWM 260 FGEENGSDPN 270 IHEEKEMRIM 280 TPEGKWHASK 290 VLRIENIGES 300 NLNVLYNCTV 310 ASTGGTDTKS 320 FILVRKADMA 330 DIPGHVFTRG 340 MIIAVLILVA 350 VVCLVTVCVI 360 YRVDLVLFYR 370 HLTRRDETLT 380 DGKTYDAFVS 390 YLKECRPENG 400 EEHTFAVEIL 410 PRVLEKHFGY 420 KLCIFERDVV 430 PGGAVVDEIH 440 SLIEKSRRLI 450 IVLSKSYMSN 460 EVRYELESGL 470 HEALVERKIK 480 IILIEFTPVT 490 DFTFLPQSLK 500 LLKSHRVLKW 510 KADKSLSYNS 520 RFWKNLLYLM 530 PAKTVKPGRD 540 EPEVLPVLSE S

Gene Ontology

Classification	GO ID	Description
Biological Process	GO:0032729	positive regulation of type II interferon production
Cellular Component	GO:0009986	cell surface
Cellular Component	GO:0045092	interleukin-18 receptor complex
Cellular Component	GO:0005886	plasma membrane
Molecular Function	GO:0004908	interleukin-1 receptor activity
Molecular Function	GO:0042007	interleukin-18 binding
Molecular Function	GO:0042008	interleukin-18 receptor activity
Molecular Function	GO:0061809	NAD+ nucleosidase activity, cyclic ADP-ribose generating
Molecular Function	GO:0038023	signaling receptor activity
Biological Process	GO:0002250	adaptive immune response
Biological Process	GO:0071222	cellular response to lipopolysaccharide
Biological Process	GO:0050830	defense response to Gram-positive bacterium
Biological Process	GO:0006955	immune response
Biological Process	GO:0006954	inflammatory response
Biological Process	GO:0035655	interleukin-18-mediated signaling pathway
Biological Process	GO:0120163	negative regulation of cold-induced thermogenesis
Biological Process	GO:1901224	positive regulation of non-canonical NF-kappaB signal transduction
Biological Process	GO:2000556	positive regulation of T-helper 1 cell cytokine production
Biological Process	GO:0007165	signal transduction
Biological Process	GO:0045063	T-helper 1 cell differentiation

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.