Search Results

Overview

Uniprot ID	Q13509
Protein Name	Tubulin beta-3 chain
Gene Name	TUBB3
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
58	YNEASSHKYVPRAIL

Function

Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:34996871, PubMed:38305685, PubMed:38609661). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:34996871, PubMed:38305685, PubMed:38609661). Below the cap, alpha-beta tubulin heterodimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871, PubMed:38609661). TUBB3 plays a critical role in proper axon guidance and maintenance (PubMed:20074521). Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Plays a role in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977)

Protein Sequence

10 MREIVHIQAG 20 QCGNQIGAKF 30 WEVISDEHGI 40 DPSGNYVGDS 50 DLQLERISVY 60 YNEASSHKYV 70 PRAILVDLEP 80 GTMDSVRSGA 90 FGHLFRPDNF 100 IFGQSGAGNN 110 WAKGHYTEGA 120 ELVDSVLDVV 130 RKECENCDCL 140 QGFQLTHSLG 150 GGTGSGMGTL 160 LISKVREEYP 170 DRIMNTFSVV 180 PSPKVSDTVV 190 EPYNATLSIH 200 QLVENTDETY 210 CIDNEALYDI 220 CFRTLKLATP 230 TYGDLNHLVS 240 ATMSGVTTSL 250 RFPGQLNADL 260 RKLAVNMVPF 270 PRLHFFMPGF 280 APLTARGSQQ 290 YRALTVPELT 300 QQMFDAKNMM 310 AACDPRHGRY 320 LTVATVFRGR 330 MSMKEVDEQM 340 LAIQSKNSSY 350 FVEWIPNNVK 360 VAVCDIPPRG 370 LKMSSTFIGN 380 STAIQELFKR 390 ISEQFTAMFR 400 RKAFLHWYTG 410 EGMDEMEFTE 420 AESNMNDLVS 430 EYQQYQDATA 440 EEEGEMYEDD 450 EEESEAQGPK

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0030424	axon
Cellular Component	GO:0071944	cell periphery
Cellular Component	GO:0097542	ciliary tip
Cellular Component	GO:0005929	cilium
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0030425	dendrite
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0030175	filopodium
Cellular Component	GO:0030426	growth cone
Cellular Component	GO:0045171	intercellular bridge
Cellular Component	GO:0030027	lamellipodium
Cellular Component	GO:0005874	microtubule
Cellular Component	GO:0015630	microtubule cytoskeleton
Cellular Component	GO:0072686	mitotic spindle
Cellular Component	GO:0043025	neuronal cell body
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0097229	sperm end piece
Cellular Component	GO:0097228	sperm principal piece
Molecular Function	GO:0005525	GTP binding
Molecular Function	GO:0003924	GTPase activity
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:1990890	netrin receptor binding
Molecular Function	GO:0042277	peptide binding
Molecular Function	GO:0005200	structural constituent of cytoskeleton
Biological Process	GO:0007411	axon guidance
Biological Process	GO:1990791	dorsal root ganglion development
Biological Process	GO:0000226	microtubule cytoskeleton organization
Biological Process	GO:0000278	mitotic cell cycle

Reference

[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.