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Overview

Uniprot IDQ13554
Protein NameCalcium/calmodulin-dependent protein kinase type II subunit beta
Gene NameCAMK2B
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
147 ENLLLASKCKGAAVK
292 QETVECLKKFNARRK
43 TGHEYAAKIINTKKL

Function

Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle (PubMed:16690701). In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Also regulates the migration of developing neurons (PubMed:29100089). Participates in the modulation of skeletal muscle function in response to exercise (PubMed:16690701). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). Phosphorylates reticulophagy regulator RETREG1 at 'Ser-151' under endoplasmic reticulum stress conditions which enhances RETREG1 oligomerization and its membrane scission and reticulophagy activity (PubMed:31930741)

Protein Sequence

10 MATTVTCTRF 20 TDEYQLYEDI 30 GKGAFSVVRR 40 CVKLCTGHEY 50 AAKIINTKKL 60 SARDHQKLER 70 EARICRLLKH 80 SNIVRLHDSI 90 SEEGFHYLVF 100 DLVTGGELFE 110 DIVAREYYSE 120 ADASHCIQQI 130 LEAVLHCHQM 140 GVVHRDLKPE 150 NLLLASKCKG 160 AAVKLADFGL 170 AIEVQGDQQA 180 WFGFAGTPGY 190 LSPEVLRKEA 200 YGKPVDIWAC 210 GVILYILLVG 220 YPPFWDEDQH 230 KLYQQIKAGA 240 YDFPSPEWDT 250 VTPEAKNLIN 260 QMLTINPAKR 270 ITAHEALKHP 280 WVCQRSTVAS 290 MMHRQETVEC 300 LKKFNARRKL 310 KGAILTTMLA 320 TRNFSVGRQT 330 TAPATMSTAA 340 SGTTMGLVEQ 350 AKSLLNKKAD 360 GVKPQTNSTK 370 NSAAATSPKG 380 TLPPAALEPQ 390 TTVIHNPVDG 400 IKESSDSANT 410 TIEDEDAKAP 420 RVPDILSSVR 430 RGSGAPEAEG 440 PLPCPSPAPF 450 SPLPAPSPRI 460 SDILNSVRRG 470 SGTPEAEGPL 480 SAGPPPCLSP 490 ALLGPLSSPS 500 PRISDILNSV 510 RRGSGTPEAE 520 GPSPVGPPPC 530 PSPTIPGPLP 540 TPSRKQEIIK 550 TTEQLIEAVN 560 NGDFEAYAKI 570 CDPGLTSFEP 580 EALGNLVEGM 590 DFHRFYFENL 600 LAKNSKPIHT 610 TILNPHVHVI 620 GEDAACIAYI 630 RLTQYIDGQG 640 RPRTSQSEET 650 RVWHRRDGKW 660 QNVHFHCSGA PVAPLQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005954 calcium- and calmodulin-dependent protein kinase complex
Cellular Component GO:0005813 centrosome
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0030666 endocytic vesicle membrane
Cellular Component GO:0043005 neuron projection
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0014069 postsynaptic density
Cellular Component GO:0033017 sarcoplasmic reticulum membrane
Molecular Function GO:0003779 actin binding
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0004683 calcium/calmodulin-dependent protein kinase activity
Molecular Function GO:0005516 calmodulin binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0042803 protein homodimerization activity
Molecular Function GO:0106310 protein serine kinase activity
Biological Process GO:0030154 cell differentiation
Biological Process GO:0060291 long-term synaptic potentiation
Biological Process GO:0007399 nervous system development
Biological Process GO:0061003 positive regulation of dendritic spine morphogenesis
Biological Process GO:0010976 positive regulation of neuron projection development
Biological Process GO:0090129 positive regulation of synapse maturation
Biological Process GO:0046777 protein autophosphorylation
Biological Process GO:0006468 protein phosphorylation
Biological Process GO:0051924 regulation of calcium ion transport
Biological Process GO:0060998 regulation of dendritic spine development
Biological Process GO:0048169 regulation of long-term neuronal synaptic plasticity
Biological Process GO:2001222 regulation of neuron migration
Biological Process GO:0048168 regulation of neuronal synaptic plasticity
Biological Process GO:1903076 regulation of protein localization to plasma membrane
Biological Process GO:0014733 regulation of skeletal muscle adaptation
Biological Process GO:0051823 regulation of synapse structural plasticity
Biological Process GO:0007165 signal transduction

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.