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Overview

Uniprot IDQ13555
Protein NameCalcium/calmodulin-dependent protein kinase type II subunit gamma
Gene NameCAMK2G
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
318 SRNFSAAKSLLNKKS
43 STQEYAAKIINTKKL

Function

Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity (PubMed:16690701). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin (PubMed:16690701). In the central nervous system, it is involved in the regulation of neurite formation and arborization (PubMed:30184290). It may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity)

Protein Sequence

10 MATTATCTRF 20 TDDYQLFEEL 30 GKGAFSVVRR 40 CVKKTSTQEY 50 AAKIINTKKL 60 SARDHQKLER 70 EARICRLLKH 80 PNIVRLHDSI 90 SEEGFHYLVF 100 DLVTGGELFE 110 DIVAREYYSE 120 ADASHCIHQI 130 LESVNHIHQH 140 DIVHRDLKPE 150 NLLLASKCKG 160 AAVKLADFGL 170 AIEVQGEQQA 180 WFGFAGTPGY 190 LSPEVLRKDP 200 YGKPVDIWAC 210 GVILYILLVG 220 YPPFWDEDQH 230 KLYQQIKAGA 240 YDFPSPEWDT 250 VTPEAKNLIN 260 QMLTINPAKR 270 ITADQALKHP 280 WVCQRSTVAS 290 MMHRQETVEC 300 LRKFNARRKL 310 KGAILTTMLV 320 SRNFSAAKSL 330 LNKKSDGGVK 340 KRKSSSSVHL 350 MPQSNNKNSL 360 VSPAQEPAPL 370 QTAMEPQTTV 380 VHNATDGIKG 390 STESCNTTTE 400 DEDLKGRVPE 410 GRSSRDRTAP 420 SAGMQPQPSL 430 CSSAMRKQEI 440 IKITEQLIEA 450 INNGDFEAYT 460 KICDPGLTSF 470 EPEALGNLVE 480 GMDFHKFYFE 490 NLLSKNSKPI 500 HTTILNPHVH 510 VIGEDAACIA 520 YIRLTQYIDG 530 QGRPRTSQSE 540 ETRVWHRRDG 550 KWLNVHYHCS GAPAAPLQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005954 calcium- and calmodulin-dependent protein kinase complex
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0030666 endocytic vesicle membrane
Cellular Component GO:0016020 membrane
Cellular Component GO:0043005 neuron projection
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0014069 postsynaptic density
Cellular Component GO:0033017 sarcoplasmic reticulum membrane
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0004723 calcium-dependent protein serine/threonine phosphatase activity
Molecular Function GO:0004683 calcium/calmodulin-dependent protein kinase activity
Molecular Function GO:0005516 calmodulin binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0042803 protein homodimerization activity
Molecular Function GO:0106310 protein serine kinase activity
Biological Process GO:0030154 cell differentiation
Biological Process GO:0030073 insulin secretion
Biological Process GO:0060291 long-term synaptic potentiation
Biological Process GO:0007399 nervous system development
Biological Process GO:0051924 regulation of calcium ion transport
Biological Process GO:0010975 regulation of neuron projection development
Biological Process GO:0048168 regulation of neuronal synaptic plasticity
Biological Process GO:1903076 regulation of protein localization to plasma membrane
Biological Process GO:0014733 regulation of skeletal muscle adaptation

Reference

[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.