Search Results

Overview

Uniprot IDQ13561
Protein NameDynactin subunit 2
Gene NameDCTN2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
125 EKIKTTVKESATEEK
132 KESATEEKLTPVLLA
140 LTPVLLAKQLAALKQ
146 AKQLAALKQQLVASH
194 SKGGSGGKTTGTPPD
5 ***MADPKYADLPGI
65 KDKRVGTKGLDFSDR

Function

Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. In the dynactin soulder domain, binds the ACTR1A filament and acts as a molecular ruler to determine the length (By similarity). Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development (By similarity)

Protein Sequence

10 MADPKYADLP 20 GIARNEPDVY 30 ETSDLPEDDQ 40 AEFDAEELTS 50 TSVEHIIVNP 60 NAAYDKFKDK 70 RVGTKGLDFS 80 DRIGKTKRTG 90 YESGEYEMLG 100 EGLGVKETPQ 110 QKYQRLLHEV 120 QELTTEVEKI 130 KTTVKESATE 140 EKLTPVLLAK 150 QLAALKQQLV 160 ASHLEKLLGP 170 DAAINLTDPD 180 GALAKRLLLQ 190 LEATKNSKGG 200 SGGKTTGTPP 210 DSSLVTYELH 220 SRPEQDKFSQ 230 AAKVAELEKR 240 LTELETAVRC 250 DQDAQNPLSA 260 GLQGACLMET 270 VELLQAKVSA 280 LDLAVLDQVE 290 ARLQSVLGKV 300 NEIAKHKASV 310 EDADTQSKVH 320 QLYETIQRWS 330 PIASTLPELV 340 QRLVTIKQLH 350 EQAMQFGQLL 360 THLDTTQQMI 370 ANSLKDNTTL 380 LTQVQTTMRE 390 NLATVEGNFA 400 SIDERMKKLG K

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005813 centrosome
Cellular Component GO:0036064 ciliary basal body
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005869 dynactin complex
Cellular Component GO:0030286 dynein complex
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0030426 growth cone
Cellular Component GO:0000776 kinetochore
Cellular Component GO:0016020 membrane
Cellular Component GO:0005874 microtubule
Cellular Component GO:0031982 vesicle
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0019901 protein kinase binding
Molecular Function GO:0030507 spectrin binding
Biological Process GO:0007080 mitotic metaphase chromosome alignment
Biological Process GO:0007052 mitotic spindle organization
Biological Process GO:0071539 protein localization to centrosome

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.