Search Results

Overview

Uniprot ID	Q13576
Protein Name	Ras GTPase-activating-like protein IQGAP2
Gene Name	IQGAP2
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
102	VEQTRYKKSGLHFRH
1043	TYPEVKNKLEASIEN
1081	RYIAKVLKNSIHEKF
1143	RNLGSVAKVLQHAAS
1305	SLMIKTKKLIIDVIR
1392	GHVSSENKYQDILNE
1430	QTLNALNKKAAFYEE
1431	TLNALNKKAAFYEEQ
1454	KTCLDNLKRKNTRRS
1485	PVKYTAAKLHEKGVL
406	IGLNNLDKAYVERYA
505	LYHAKSQKLGDSESV
553	NQCLEGKKSSDILSV
602	SSDGSWLKLNLHKKY
608	LKLNLHKKYDYYYNT
684	REEFEARKSFLHEQE
850	EDVISHSKKLNKKKG
91	PKMVSEKKIYDVEQT
910	IFQMPQNKSTKFMDT
950	LEEEIKSKVDQVQDI

Function

Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin

Protein Sequence

10 MPHEELPSLQ 20 RPRYGSIVDD 30 ERLSAEEMDE 40 RRRQNIAYEY 50 LCHLEEAKRW 60 MEVCLVEELP 70 PTTELEEGLR 80 NGVYLAKLAK 90 FFAPKMVSEK 100 KIYDVEQTRY 110 KKSGLHFRHT 120 DNTVQWLRAM 130 ESIGLPKIFY 140 PETTDVYDRK 150 NIPRMIYCIH 160 ALSLYLFKLG 170 IAPQIQDLLG 180 KVDFTEEEIS 190 NMRKELEKYG 200 IQMPSFSKIG 210 GILANELSVD 220 EAALHAAVIA 230 INEAVEKGIA 240 EQTVVTLRNP 250 NAVLTLVDDN 260 LAPEYQKELW 270 DAKKKKEENA 280 RLKNSCISEE 290 ERDAYEELLT 300 QAEIQGNINK 310 VNRQAAVDHI 320 NAVIPEGDPE 330 NTLLALKKPE 340 AQLPAVYPFA 350 AAMYQNELFN 360 LQKQNTMNYL 370 AHEELLIAVE 380 MLSAVALLNQ 390 ALESNDLVSV 400 QNQLRSPAIG 410 LNNLDKAYVE 420 RYANTLLSVK 430 LEVLSQGQDN 440 LSWNEIQNCI 450 DMVNAQIQEE 460 NDRVVAVGYI 470 NEAIDEGNPL 480 RTLETLLLPT 490 ANISDVDPAH 500 AQHYQDVLYH 510 AKSQKLGDSE 520 SVSKVLWLDE 530 IQQAVDDANV 540 DKDRAKQWVT 550 LVVDVNQCLE 560 GKKSSDILSV 570 LKSSTSNAND 580 IIPECADKYY 590 DALVKAKELK 600 SERVSSDGSW 610 LKLNLHKKYD 620 YYYNTDSKES 630 SWVTPESCLY 640 KESWLTGKEI 650 EDIIEEVTVG 660 YIRENIWSAS 670 EELLLRFQAT 680 SSGPILREEF 690 EARKSFLHEQ 700 EENVVKIQAF 710 WKGYKQRKEY 720 MHRRQTFIDN 730 TDSIVKIQSW 740 FRMATARKSY 750 LSRLQYFRDH 760 NNEIVKIQSL 770 LRANKARDDY 780 KTLVGSENPP 790 LTVIRKFVYL 800 LDQSDLDFQE 810 ELEVARLREE 820 VVTKIRANQQ 830 LEKDLNLMDI 840 KIGLLVKNRI 850 TLEDVISHSK 860 KLNKKKGGEM 870 EILNNTDNQG 880 IKSLSKERRK 890 TLETYQQLFY 900 LLQTNPLYLA 910 KLIFQMPQNK 920 STKFMDTVIF 930 TLYNYASNQR 940 EEYLLLKLFK 950 TALEEEIKSK 960 VDQVQDIVTG 970 NPTVIKMVVS 980 FNRGARGQNT 990 LRQLLAPVVK 1000 EIIDDKSLII 1010 NTNPVEVYKA 1020 WVNQLETQTG 1030 EASKLPYDVT 1040 TEQALTYPEV 1050 KNKLEASIEN 1060 LRRVTDKVLN 1070 SIISSLDLLP 1080 YGLRYIAKVL 1090 KNSIHEKFPD 1100 ATEDELLKIV 1110 GNLLYYRYMN 1120 PAIVAPDGFD 1130 IIDMTAGGQI 1140 NSDQRRNLGS 1150 VAKVLQHAAS 1160 NKLFEGENEH 1170 LSSMNNYLSE 1180 TYQEFRKYFK 1190 EACNVPEPEE 1200 KFNMDKYTDL 1210 VTVSKPVIYI 1220 SIEEIISTHS 1230 LLLEHQDAIA 1240 PEKNDLLSEL 1250 LGSLGEVPTV 1260 ESFLGEGAVD 1270 PNDPNKANTL 1280 SQLSKTEISL 1290 VLTSKYDIED 1300 GEAIDSRSLM 1310 IKTKKLIIDV 1320 IRNQPGNTLT 1330 EILETPATAQ 1340 QEVDHATDMV 1350 SRAMIDSRTP 1360 EEMKHSQSMI 1370 EDAQLPLEQK 1380 KRKIQRNLRT 1390 LEQTGHVSSE 1400 NKYQDILNEI 1410 AKDIRNQRIY 1420 RKLRKAELAK 1430 LQQTLNALNK 1440 KAAFYEEQIN 1450 YYDTYIKTCL 1460 DNLKRKNTRR 1470 SIKLDGKGEP 1480 KGAKRAKPVK 1490 YTAAKLHEKG 1500 VLLDIDDLQT 1510 NQFKNVTFDI 1520 IATEDVGIFD 1530 VRSKFLGVEM 1540 EKVQLNIQDL 1550 LQMQYEGVAV 1560 MKMFDKVKVN 1570 VNLLIYLLNK KFYGK

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0015629	actin cytoskeleton
Cellular Component	GO:0005938	cell cortex
Cellular Component	GO:0009986	cell surface
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0030175	filopodium
Cellular Component	GO:0030027	lamellipodium
Cellular Component	GO:0005874	microtubule
Cellular Component	GO:0005902	microvillus
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0030667	secretory granule membrane
Molecular Function	GO:0003779	actin binding
Molecular Function	GO:0051015	actin filament binding
Molecular Function	GO:0071933	Arp2/3 complex binding
Molecular Function	GO:0005516	calmodulin binding
Molecular Function	GO:0005096	GTPase activator activity
Molecular Function	GO:0005095	GTPase inhibitor activity
Molecular Function	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding
Molecular Function	GO:0031267	small GTPase binding
Biological Process	GO:0034314	Arp2/3 complex-mediated actin nucleation
Biological Process	GO:1903479	mitotic actomyosin contractile ring assembly actin filament organization
Biological Process	GO:0032956	regulation of actin cytoskeleton organization
Biological Process	GO:0007165	signal transduction
Biological Process	GO:0070493	thrombin-activated receptor signaling pathway

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.