Search Results

Overview

Uniprot IDQ13586
Protein NameStromal interaction molecule 1
Gene NameSTIM1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
279 HRTVEVEKVHLEKKL
580 PDSPALAKKALLALN
581 DSPALAKKALLALNH
650 RIPHLAGKKAVAEED
651 IPHLAGKKAVAEEDN

Function

Acts as a Ca(2+) sensor that gates two major inward rectifying Ca(2+) channels at the plasma membrane: Ca(2+) release-activated Ca(2+) (CRAC) channels and arachidonate-regulated Ca(2+)-selective (ARC) channels (PubMed:15866891, PubMed:16005298, PubMed:16208375, PubMed:16537481, PubMed:16733527, PubMed:16766533, PubMed:16807233, PubMed:18854159, PubMed:19182790, PubMed:19249086, PubMed:19622606, PubMed:19706554, PubMed:22464749, PubMed:24069340, PubMed:24351972, PubMed:24591628, PubMed:25326555, PubMed:26322679, PubMed:28219928, PubMed:32415068). Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates CRAC channel pore-forming subunits ORA1, ORA2 and ORAI3 to generate sustained and oscillatory Ca(2+) entry (PubMed:16208375, PubMed:16537481, PubMed:32415068). Involved in enamel formation (PubMed:24621671). Plays a role in regulating the type I interferon response by retaining the signaling adapter STING at the endoplasmic reticulum (PubMed:30643259)

Protein Sequence

10 MDVCVRLALW 20 LLWGLLLHQG 30 QSLSHSHSEK 40 ATGTSSGANS 50 EESTAAEFCR 60 IDKPLCHSED 70 EKLSFEAVRN 80 IHKLMDDDAN 90 GDVDVEESDE 100 FLREDLNYHD 110 PTVKHSTFHG 120 EDKLISVEDL 130 WKAWKSSEVY 140 NWTVDEVVQW 150 LITYVELPQY 160 EETFRKLQLS 170 GHAMPRLAVT 180 NTTMTGTVLK 190 MTDRSHRQKL 200 QLKALDTVLF 210 GPPLLTRHNH 220 LKDFMLVVSI 230 VIGVGGCWFA 240 YIQNRYSKEH 250 MKKMMKDLEG 260 LHRAEQSLHD 270 LQERLHKAQE 280 EHRTVEVEKV 290 HLEKKLRDEI 300 NLAKQEAQRL 310 KELREGTENE 320 RSRQKYAEEE 330 LEQVREALRK 340 AEKELESHSS 350 WYAPEALQKW 360 LQLTHEVEVQ 370 YYNIKKQNAE 380 KQLLVAKEGA 390 EKIKKKRNTL 400 FGTFHVAHSS 410 SLDDVDHKIL 420 TAKQALSEVT 430 AALRERLHRW 440 QQIEILCGFQ 450 IVNNPGIHSL 460 VAALNIDPSW 470 MGSTRPNPAH 480 FIMTDDVDDM 490 DEEIVSPLSM 500 QSPSLQSSVR 510 QRLTEPQHGL 520 GSQRDLTHSD 530 SESSLHMSDR 540 QRVAPKPPQM 550 SRAADEALNA 560 MTSNGSHRLI 570 EGVHPGSLVE 580 KLPDSPALAK 590 KALLALNHGL 600 DKAHSLMELS 610 PSAPPGGSPH 620 LDSSRSHSPS 630 SPDPDTPSPV 640 GDSRALQASR 650 NTRIPHLAGK 660 KAVAEEDNGS 670 IGEETDSSPG 680 RKKFPLKIFK KPLKK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0032541 cortical endoplasmic reticulum
Cellular Component GO:0005783 endoplasmic reticulum
Cellular Component GO:0005789 endoplasmic reticulum membrane
Cellular Component GO:0005874 microtubule
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0044853 plasma membrane raft
Cellular Component GO:0033017 sarcoplasmic reticulum membrane
Molecular Function GO:0005246 calcium channel regulator activity
Molecular Function GO:0005509 calcium ion binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0051010 microtubule plus-end binding
Molecular Function GO:0002020 protease binding
Biological Process GO:0032237 activation of store-operated calcium channel activity
Biological Process GO:0005513 detection of calcium ion
Biological Process GO:0070166 enamel mineralization
Biological Process GO:0006874 intracellular calcium ion homeostasis
Biological Process GO:0045762 positive regulation of adenylate cyclase activity
Biological Process GO:0045766 positive regulation of angiogenesis
Biological Process GO:0051924 regulation of calcium ion transport
Biological Process GO:2001256 regulation of store-operated calcium entry
Biological Process GO:0002115 store-operated calcium entry

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.