Search Results

Overview

Uniprot ID	Q13595
Protein Name	Transformer-2 protein homolog alpha
Gene Name	TRA2A
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
198	RVDYSITKRAHTPTP

Function

Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing

Protein Sequence

10 MSDVEENNFE 20 GRESRSQSKS 30 PTGTPARVKS 40 ESRSGSRSPS 50 RVSKHSESHS 60 RSRSKSRSRS 70 RRHSHRRYTR 80 SRSHSHSHRR 90 RSRSRSYTPE 100 YRRRRSRSHS 110 PMSNRRRHTG 120 SRANPDPNTC 130 LGVFGLSLYT 140 TERDLREVFS 150 RYGPLSGVNV 160 VYDQRTGRSR 170 GFAFVYFERI 180 DDSKEAMERA 190 NGMELDGRRI 200 RVDYSITKRA 210 HTPTPGIYMG 220 RPTHSGGGGG 230 GGGGGGGGGG 240 GRRRDSYYDR 250 GYDRGYDRYE 260 DYDYRYRRRS 270 PSPYYSRYRS 280 RSRSRSYSPR RY

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005730	nucleolus
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0005681	spliceosomal complex
Molecular Function	GO:0003729	mRNA binding
Molecular Function	GO:0003723	RNA binding
Biological Process	GO:0000398	mRNA splicing, via spliceosome

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[5] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[6] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[7] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.