Search Results

Overview

Uniprot IDQ13596
Protein NameSorting nexin-1
Gene NameSNX1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
290 GLLKMFNKATDAVSK
297 KATDAVSKMTIKMNE
325 CEEQRLRKLHAVVET

Function

Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:12198132). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed:19816406, PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptors (IGF2R, M6PR and SORT1) and Shiginella dysenteria toxin stxB. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi (PubMed:12198132, PubMed:15498486, PubMed:17101778, PubMed:17550970, PubMed:18088323, PubMed:21040701). Involvement in retromer-independent endocytic trafficking of P2RY1 and lysosomal degradation of protease-activated receptor-1/F2R (PubMed:16407403, PubMed:20070609). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN (PubMed:20604901). Required for endocytosis of DRD5 upon agonist stimulation but not for basal receptor trafficking (PubMed:23152498)

Protein Sequence

10 MASGGGGCSA 20 SERLPPPFPG 30 LEPESEGAAG 40 GSEPEAGDSD 50 TEGEDIFTGA 60 AVVSKHQSPK 70 ITTSLLPINN 80 GSKENGIHEE 90 QDQEPQDLFA 100 DATVELSLDS 110 TQNNQKKVLA 120 KTLISLPPQE 130 ATNSSKPQPT 140 YEELEEEEQE 150 DQFDLTVGIT 160 DPEKIGDGMN 170 AYVAYKVTTQ 180 TSLPLFRSKQ 190 FAVKRRFSDF 200 LGLYEKLSEK 210 HSQNGFIVPP 220 PPEKSLIGMT 230 KVKVGKEDSS 240 SAEFLEKRRA 250 ALERYLQRIV 260 NHPTMLQDPD 270 VREFLEKEEL 280 PRAVGTQTLS 290 GAGLLKMFNK 300 ATDAVSKMTI 310 KMNESDIWFE 320 EKLQEVECEE 330 QRLRKLHAVV 340 ETLVNHRKEL 350 ALNTAQFAKS 360 LAMLGSSEDN 370 TALSRALSQL 380 AEVEEKIEQL 390 HQEQANNDFF 400 LLAELLSDYI 410 RLLAIVRAAF 420 DQRMKTWQRW 430 QDAQATLQKK 440 REAEARLLWA 450 NKPDKLQQAK 460 DEILEWESRV 470 TQYERDFERI 480 STVVRKEVIR 490 FEKEKSKDFK 500 NHVIKYLETL 510 LYSQQQLAKY 520 WEAFLPEAKA IS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0030905 retromer, tubulation complex
Cellular Component GO:0031982 vesicle
Molecular Function GO:0045296 cadherin binding
Molecular Function GO:0005154 epidermal growth factor receptor binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0005158 insulin receptor binding
Molecular Function GO:1990460 leptin receptor binding
Molecular Function GO:0035091 phosphatidylinositol binding
Molecular Function GO:0046982 protein heterodimerization activity
Molecular Function GO:0042803 protein homodimerization activity
Molecular Function GO:1990459 transferrin receptor binding
Biological Process GO:0034498 early endosome to Golgi transport
Biological Process GO:0097750 endosome membrane tubulation
Biological Process GO:0006886 intracellular protein transport
Biological Process GO:0072673 lamellipodium morphogenesis
Biological Process GO:0045732 positive regulation of protein catabolic process
Biological Process GO:0031623 receptor internalization
Biological Process GO:0042147 retrograde transport, endosome to Golgi
Cellular Component GO:0005829 cytosol
Cellular Component GO:0031901 early endosome membrane
Cellular Component GO:0005768 endosome
Cellular Component GO:0010008 endosome membrane
Cellular Component GO:0005794 Golgi apparatus
Cellular Component GO:0030027 lamellipodium
Cellular Component GO:0005764 lysosome
Cellular Component GO:0016020 membrane
Cellular Component GO:0032991 protein-containing complex
Cellular Component GO:0030904 retromer complex

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.