Search Results

Overview

Uniprot ID	Q13601
Protein Name	KRR1 small subunit processome component homolog
Gene Name	KRR1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
11	PSLERPEKGAGKSEF
290	ASGEYFLKANQKKRQ
298	ANQKKRQKMEAIKAK

Function

Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome

Protein Sequence

10 MASPSLERPE 20 KGAGKSEFRN 30 QKPKPENQDE 40 SELLTVPDGW 50 KEPAFSKEDN 60 PRGLLEESSF 70 ATLFPKYREA 80 YLKECWPLVQ 90 KALNEHHVNA 100 TLDLIEGSMT 110 VCTTKKTFDP 120 YIIIRARDLI 130 KLLARSVSFE 140 QAVRILQDDV 150 ACDIIKIGSL 160 VRNKERFVKR 170 RQRLIGPKGS 180 TLKALELLTN 190 CYIMVQGNTV 200 SAIGPFSGLK 210 EVRKVVLDTM 220 KNIHPIYNIK 230 SLMIKRELAK 240 DSELRSQSWE 250 RFLPQFKHKN 260 VNKRKEPKKK 270 TVKKEYTPFP 280 PPQPESQIDK 290 ELASGEYFLK 300 ANQKKRQKME 310 AIKAKQAEAI 320 SKRQEERNKA 330 FIPPKEKPIV 340 KPKEASTETK 350 IDVASIKEKV 360 KKAKNKKLGA 370 LTAEEIALKM 380 EADEKKKKKK K

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0005730	nucleolus
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0032040	small-subunit processome
Molecular Function	GO:0003723	RNA binding
Biological Process	GO:0030490	maturation of SSU-rRNA
Biological Process	GO:0042274	ribosomal small subunit biogenesis

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.