Search Results
Overview
| Uniprot ID | Q13625 |
|---|---|
| Protein Name | Apoptosis-stimulating of p53 protein 2 |
| Gene Name | TP53BP2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 477 | PSFGTLRKNQSSEDI |
Function
Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions with proteins such as TP53 (PubMed:12524540). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of NAE1 to conjugate NEDD8 to CUL1, and thereby decreases NAE1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42
Protein Sequence
10
MMPMFLTVYL
20
SNNEQHFTEV
30
PVTPETICRD
40
VVDLCKEPGE
50
SDCHLAEVWC
60
GSERPVADNE
70
RMFDVLQRFG
80
SQRNEVRFFL
90
RHERPPGRDI
100
VSGPRSQDPS
110
LKRNGVKVPG
120
EYRRKENGVN
130
SPRMDLTLAE
140
LQEMASRQQQ
150
QIEAQQQLLA
160
TKEQRLKFLK
170
QQDQRQQQQV
180
AEQEKLKRLK
190
EIAENQEAKL
200
KKVRALKGHV
210
EQKRLSNGKL
220
VEEIEQMNNL
230
FQQKQRELVL
240
AVSKVEELTR
250
QLEMLKNGRI
260
DSHHDNQSAV
270
AELDRLYKEL
280
QLRNKLNQEQ
290
NAKLQQQREC
300
LNKRNSEVAV
310
MDKRVNELRD
320
RLWKKKAALQ
330
QKENLPVSSD
340
GNLPQQAASA
350
PSRVAAVGPY
360
IQSSTMPRMP
370
SRPELLVKPA
380
LPDGSLVIQA
390
SEGPMKIQTL
400
PNMRSGAASQ
410
TKGSKIHPVG
420
PDWSPSNADL
430
FPSQGSASVP
440
QSTGNALDQV
450
DDGEVPLREK
460
EKKVRPFSMF
470
DAVDQSNAPP
480
SFGTLRKNQS
490
SEDILRDAQV
500
ANKNVAKVPP
510
PVPTKPKQIN
520
LPYFGQTNQP
530
PSDIKPDGSS
540
QQLSTVVPSM
550
GTKPKPAGQQ
560
PRVLLSPSIP
570
SVGQDQTLSP
580
GSKQESPPAA
590
AVRPFTPQPS
600
KDTLLPPFRK
610
PQTVAASSIY
620
SMYTQQQAPG
630
KNFQQAVQSA
640
LTKTHTRGPH
650
FSSVYGKPVI
660
AAAQNQQQHP
670
ENIYSNSQGK
680
PGSPEPETEP
690
VSSVQENHEN
700
ERIPRPLSPT
710
KLLPFLSNPY
720
RNQSDADLEA
730
LRKKLSNAPR
740
PLKKRSSITE
750
PEGPNGPNIQ
760
KLLYQRTTIA
770
AMETISVPSY
780
PSKSASVTAS
790
SESPVEIQNP
800
YLHVEPEKEV
810
VSLVPESLSP
820
EDVGNASTEN
830
SDMPAPSPGL
840
DYEPEGVPDN
850
SPNLQNNPEE
860
PNPEAPHVLD
870
VYLEEYPPYP
880
PPPYPSGEPE
890
GPGEDSVSMR
900
PPEITGQVSL
910
PPGKRTNLRK
920
TGSERIAHGM
930
RVKFNPLALL
940
LDSSLEGEFD
950
LVQRIIYEVD
960
DPSLPNDEGI
970
TALHNAVCAG
980
HTEIVKFLVQ
990
FGVNVNAADS
1000
DGWTPLHCAA
1010
SCNNVQVCKF
1020
LVESGAAVFA
1030
MTYSDMQTAA
1040
DKCEEMEEGY
1050
TQCSQFLYGV
1060
QEKMGIMNKG
1070
VIYALWDYEP
1080
QNDDELPMKE
1090
GDCMTIIHRE
1100
DEDEIEWWWA
1110
RLNDKEGYVP
1120
RNLLGLYPRI
KPRQRSLA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030054 | cell junction |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0051059 | NF-kappaB binding |
| Molecular Function | GO:0002039 | p53 binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0017124 | SH3 domain binding |
| Biological Process | GO:0072332 | intrinsic apoptotic signaling pathway by p53 class mediator |
| Biological Process | GO:0045786 | negative regulation of cell cycle |
| Biological Process | GO:1900119 | positive regulation of execution phase of apoptosis |
| Biological Process | GO:0007165 | signal transduction |
| Cellular Component | GO:0005737 | cytoplasm |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.