Search Results
Overview
| Uniprot ID | Q13630 |
|---|---|
| Protein Name | GDP-L-fucose synthase |
| Gene Name | GFUS |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 199 | IHKVHLAKSSGSALT |
| 21 | GGSGLVGKAIQKVVA |
| 288 | KKTASNSKLRTYLPD |
| 89 | YNLDFWRKNVHMNDN |
Function
Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction
Protein Sequence
10
MGEPQGSMRI
20
LVTGGSGLVG
30
KAIQKVVADG
40
AGLPGEDWVF
50
VSSKDADLTD
60
TAQTRALFEK
70
VQPTHVIHLA
80
AMVGGLFRNI
90
KYNLDFWRKN
100
VHMNDNVLHS
110
AFEVGARKVV
120
SCLSTCIFPD
130
KTTYPIDETM
140
IHNGPPHNSN
150
FGYSYAKRMI
160
DVQNRAYFQQ
170
YGCTFTAVIP
180
TNVFGPHDNF
190
NIEDGHVLPG
200
LIHKVHLAKS
210
SGSALTVWGT
220
GNPRRQFIYS
230
LDLAQLFIWV
240
LREYNEVEPI
250
ILSVGEEDEV
260
SIKEAAEAVV
270
EAMDFHGEVT
280
FDTTKSDGQF
290
KKTASNSKLR
300
TYLPDFRFTP
310
FKQAVKETCA
320
WFTDNYEQAR
K
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Molecular Function | GO:0009055 | electron transfer activity |
| Molecular Function | GO:0042356 | GDP-4-dehydro-D-rhamnose reductase activity |
| Molecular Function | GO:0050577 | GDP-L-fucose synthase activity |
| Molecular Function | GO:0047918 | GDP-mannose 3,5-epimerase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Biological Process | GO:0042351 | 'de novo' GDP-L-fucose biosynthetic process |
| Biological Process | GO:0019673 | GDP-mannose metabolic process |
| Biological Process | GO:0007159 | leukocyte cell-cell adhesion |
| Biological Process | GO:0010595 | positive regulation of endothelial cell migration |
| Biological Process | GO:1904906 | positive regulation of endothelial cell-matrix adhesion |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.