Search Results

Overview

Uniprot IDQ13642
Protein NameFour and a half LIM domains protein 1
Gene NameFHL1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
118 GDQNVEYKGTVWHKD
124 YKGTVWHKDCFTCSN
144 GTGSFFPKGEDFYCV
157 CVTCHETKFAKHCVK
160 CHETKFAKHCVKCNK
17 CRDPLQGKKYVQKDG
214 YYCVDCYKNFVAKKC
22 QGKKYVQKDGHHCCL
4 ****MAEKFDCHYCR
52 KPIGADSKEVHYKNR
57 DSKEVHYKNRFWHDT
70 DTCFRCAKCLHPLAN
86 TFVAKDNKILCNKCT

Function

May have an involvement in muscle development or hypertrophy

Protein Sequence

10 MAEKFDCHYC 20 RDPLQGKKYV 30 QKDGHHCCLK 40 CFDKFCANTC 50 VECRKPIGAD 60 SKEVHYKNRF 70 WHDTCFRCAK 80 CLHPLANETF 90 VAKDNKILCN 100 KCTTREDSPK 110 CKGCFKAIVA 120 GDQNVEYKGT 130 VWHKDCFTCS 140 NCKQVIGTGS 150 FFPKGEDFYC 160 VTCHETKFAK 170 HCVKCNKAIT 180 SGGITYQDQP 190 WHADCFVCVT 200 CSKKLAGQRF 210 TAVEDQYYCV 220 DCYKNFVAKK 230 CAGCKNPITG 240 KRTVSRVSHP 250 VSKARKPPVC 260 HGKRLPLTLF 270 PSANLRGRHP 280 GGERTCPSWV 290 VVLYRKNRSL 300 AAPRGPGLVK 310 APVWWPMKDN 320 PGTTTASTAK NAP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0099103 channel activator activity
Molecular Function GO:0099104 potassium channel activator activity
Molecular Function GO:0044325 transmembrane transporter binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0009887 animal organ morphogenesis
Biological Process GO:0030154 cell differentiation
Biological Process GO:0007517 muscle organ development
Biological Process GO:0030308 negative regulation of cell growth
Biological Process GO:2000134 negative regulation of G1/S transition of mitotic cell cycle
Biological Process GO:0010972 negative regulation of G2/M transition of mitotic cell cycle
Biological Process GO:1901381 positive regulation of potassium ion transmembrane transport
Biological Process GO:0060371 regulation of atrial cardiac muscle cell membrane depolarization

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[4] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[5] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[6] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.