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Overview

Uniprot IDQ13643
Protein NameFour and a half LIM domains protein 3
Gene NameFHL3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
145 SRSFVPDKGAHYCVP

Function

Recruited by SOX15 to FOXK1 promoters where it acts as a transcriptional coactivator of FOXK1

Protein Sequence

10 MSESFDCAKC 20 NESLYGRKYI 30 QTDSGPYCVP 40 CYDNTFANTC 50 AECQQLIGHD 60 SRELFYEDRH 70 FHEGCFRCCR 80 CQRSLADEPF 90 TCQDSELLCN 100 DCYCSAFSSQ 110 CSACGETVMP 120 GSRKLEYGGQ 130 TWHEHCFLCS 140 GCEQPLGSRS 150 FVPDKGAHYC 160 VPCYENKFAP 170 RCARCSKTLT 180 QGGVTYRDQP 190 WHRECLVCTG 200 CQTPLAGQQF 210 TSRDEDPYCV 220 ACFGELFAPK 230 CSSCKRPIVG 240 LGGGKYVSFE 250 DRHWHHNCFS 260 CARCSTSLVG 270 QGFVPDGDQV 280 LCQGCSQAGP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0005634 nucleus
Cellular Component GO:0001725 stress fiber
Cellular Component GO:0030018 Z disc
Molecular Function GO:0003779 actin binding
Molecular Function GO:0003712 transcription coregulator activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0030036 actin cytoskeleton organization
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0007517 muscle organ development

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.