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Overview

Uniprot IDQ13671
Protein NameRas and Rab interactor 1
Gene NameRIN1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
207 GPVLPQLKARSPQEL

Function

Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis

Protein Sequence

10 MESPGESGAG 20 SPGAPSPSSF 30 TTGHLAREKP 40 AQDPLYDVPN 50 ASGGQAGGPQ 60 RPGRVVSLRE 70 RLLLTRPVWL 80 QLQANAAAAL 90 HMLRTEPPGT 100 FLVRKSNTRQ 110 CQALCMRLPE 120 ASGPSFVSSH 130 YILESPGGVS 140 LEGSELMFPD 150 LVQLICAYCH 160 TRDILLLPLQ 170 LPRAIHHAAT 180 HKELEAISHL 190 GIEFWSSSLN 200 IKAQRGPAGG 210 PVLPQLKARS 220 PQELDQGTGA 230 ALCFFNPLFP 240 GDLGPTKREK 250 FKRSFKVRVS 260 TETSSPLSPP 270 AVPPPPVPVL 280 PGAVPSQTER 290 LPPCQLLRRE 300 SSVGYRVPAG 310 SGPSLPPMPS 320 LQEVDCGSPS 330 SSEEEGVPGS 340 RGSPATSPHL 350 GRRRPLLRSM 360 SAAFCSLLAP 370 ERQVGRAAAA 380 LMQDRHTAAG 390 QLVQDLLTQV 400 RAGPEPQELQ 410 GIRQALSRAR 420 AMLSAELGPE 430 KLLSPKRLEH 440 VLEKSLHCSV 450 LKPLRPILAA 460 RLRRRLAADG 470 SLGRLAEGLR 480 LARAQGPGAF 490 GSHLSLPSPV 500 ELEQVRQKLL 510 QLLRTYSPSA 520 QVKRLLQACK 530 LLYMALRTQE 540 GEGAGADEFL 550 PLLSLVLAHC 560 DLPELLLEAE 570 YMSELLEPSL 580 LTGEGGYYLT 590 SLSASLALLS 600 GLGQAHTLPL 610 SPVQELRRSL 620 SLWEQRRLPA 630 THCFQHLLRV 640 AYQDPSSGCT 650 SKTLAVPPEA 660 SIATLNQLCA 670 TKFRVTQPNT 680 FGLFLYKEQG 690 YHRLPPGALA 700 HRLPTTGYLV 710 YRRAEWPETQ 720 GAVTEEEGSG 730 QSEARSRGEE 740 QGCQGDGDAG 750 VKASPRDIRE 760 QSETTAEGGQ 770 GQAQEGPAQP 780 GEPEAEGSRA AEE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005856 cytoskeleton
Cellular Component GO:0005829 cytosol
Cellular Component GO:0030139 endocytic vesicle
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0005096 GTPase activator activity
Molecular Function GO:0005085 guanyl-nucleotide exchange factor activity
Molecular Function GO:0031267 small GTPase binding
Biological Process GO:0006897 endocytosis
Biological Process GO:0035556 intracellular signal transduction

Reference

[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.