Search Results
Overview
| Uniprot ID | Q13733 |
|---|---|
| Protein Name | Sodium/potassium-transporting ATPase subunit alpha-4 |
| Gene Name | ATP1A4 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 944 | WADLIISKTRRNSLF |
Function
Sperm-specific catalytic alpha subunit of the Na(+)/K(+)-ATPase responsible for ATP-dependent Na(+)/K(+) exchange across the plasma membrane. Transports 3 Na(+) ions out of the cell and 2 K(+) ions into the cell for each ATP hydrolyze (PubMed:16861705). Plays an essential for sperm motility, capacitation, and male fertility by maintaining ionic gradients required for flagellar function and signaling (By similarity)
Protein Sequence
10
MGLWGKKGTV
20
APHDQSPRRR
30
PKKGLIKKKM
40
VKREKQKRNM
50
EELKKEVVMD
60
DHKLTLEELS
70
TKYSVDLTKG
80
HSHQRAKEIL
90
TRGGPNTVTP
100
PPTTPEWVKF
110
CKQLFGGFSL
120
LLWTGAILCF
130
VAYSIQIYFN
140
EEPTKDNLYL
150
SIVLSVVVIV
160
TGCFSYYQEA
170
KSSKIMESFK
180
NMVPQQALVI
190
RGGEKMQINV
200
QEVVLGDLVE
210
IKGGDRVPAD
220
LRLISAQGCK
230
VDNSSLTGES
240
EPQSRSPDFT
250
HENPLETRNI
260
CFFSTNCVEG
270
TARGIVIATG
280
DSTVMGRIAS
290
LTSGLAVGQT
300
PIAAEIEHFI
310
HLITVVAVFL
320
GVTFFALSLL
330
LGYGWLEAII
340
FLIGIIVANV
350
PEGLLATVTV
360
CLTLTAKRMA
370
RKNCLVKNLE
380
AVETLGSTST
390
ICSDKTGTLT
400
QNRMTVAHMW
410
FDMTVYEADT
420
TEEQTGKTFT
430
KSSDTWFMLA
440
RIAGLCNRAD
450
FKANQEILPI
460
AKRATTGDAS
470
ESALLKFIEQ
480
SYSSVAEMRE
490
KNPKVAEIPF
500
NSTNKYQMSI
510
HLREDSSQTH
520
VLMMKGAPER
530
ILEFCSTFLL
540
NGQEYSMNDE
550
MKEAFQNAYL
560
ELGGLGERVL
570
GFCFLNLPSS
580
FSKGFPFNTD
590
EINFPMDNLC
600
FVGLISMIDP
610
PRAAVPDAVS
620
KCRSAGIKVI
630
MVTGDHPITA
640
KAIAKGVGII
650
SEGTETAEEV
660
AARLKIPISK
670
VDASAAKAIV
680
VHGAELKDIQ
690
SKQLDQILQN
700
HPEIVFARTS
710
PQQKLIIVEG
720
CQRLGAVVAV
730
TGDGVNDSPA
740
LKKADIGIAM
750
GISGSDVSKQ
760
AADMILLDDN
770
FASIVTGVEE
780
GRLIFDNLKK
790
SIMYTLTSNI
800
PEITPFLMFI
810
ILGIPLPLGT
820
ITILCIDLGT
830
DMVPAISLAY
840
ESAESDIMKR
850
LPRNPKTDNL
860
VNHRLIGMAY
870
GQIGMIQALA
880
GFFTYFVILA
890
ENGFRPVDLL
900
GIRLHWEDKY
910
LNDLEDSYGQ
920
QWTYEQRKVV
930
EFTCQTAFFV
940
TIVVVQWADL
950
IISKTRRNSL
960
FQQGMRNKVL
970
IFGILEETLL
980
AAFLSYTPGM
990
DVALRMYPLK
1000
ITWWLCAIPY
1010
SILIFVYDEI
1020
RKLLIRQHPD
GWVERETYY
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:0036376 | sodium ion export across plasma membrane |
| Cellular Component | GO:0042995 | cell projection |
| Cellular Component | GO:0045121 | membrane raft |
| Cellular Component | GO:0097733 | photoreceptor cell cilium |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0120200 | rod photoreceptor outer segment |
| Cellular Component | GO:0005890 | sodium:potassium-exchanging ATPase complex |
| Cellular Component | GO:0097225 | sperm midpiece |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0016887 | ATP hydrolysis activity |
| Molecular Function | GO:0019829 | ATPase-coupled monoatomic cation transmembrane transporter activity |
| Molecular Function | GO:0019900 | kinase binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0005391 | P-type sodium:potassium-exchanging transporter activity |
| Biological Process | GO:0007166 | cell surface receptor signaling pathway |
| Biological Process | GO:0030317 | flagellated sperm motility |
| Biological Process | GO:0030007 | intracellular potassium ion homeostasis |
| Biological Process | GO:0006883 | intracellular sodium ion homeostasis |
| Biological Process | GO:0006811 | monoatomic ion transport |
| Biological Process | GO:1990573 | potassium ion import across plasma membrane |
| Biological Process | GO:0071805 | potassium ion transmembrane transport |
| Biological Process | GO:0006813 | potassium ion transport |
| Biological Process | GO:1902600 | proton transmembrane transport |
| Biological Process | GO:0030641 | regulation of cellular pH |
| Biological Process | GO:0035725 | sodium ion transmembrane transport |
| Biological Process | GO:0006814 | sodium ion transport |
| Biological Process | GO:0150104 | transport across blood-brain barrier |
Reference
[1] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.