Overview
| Uniprot ID | Q13740 |
|---|
| Protein Name | CD166 antigen |
|---|
| Gene Name | ALCAM |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 132 |
PTIVKVFKQPSKPEI |
| 152 |
FLETEQLKKLGDCIS |
| 76 |
AFRSSTKKSVQYDDV |
Function
Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts (PubMed:15048703, PubMed:15496415, PubMed:16352806, PubMed:23169771, PubMed:24945728, PubMed:7760007). Promotes T-cell activation and proliferation via its interactions with CD6 (PubMed:15048703, PubMed:16352806, PubMed:24945728). Contributes to the formation and maturation of the immunological synapse via its interactions with CD6 (PubMed:15294938, PubMed:16352806). Mediates homotypic interactions with cells that express ALCAM (PubMed:15496415, PubMed:16352806). Acts as a ligand for the LILRB4 receptor, enhancing LILRB4-mediated inhibition of T cell proliferation (PubMed:29263213). Required for normal hematopoietic stem cell engraftment in the bone marrow (PubMed:24740813). Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction (PubMed:23169771). Inhibits endothelial cell migration and promotes endothelial tube formation via homotypic interactions (PubMed:15496415, PubMed:23169771). Required for normal organization of the lymph vessel network. Required for normal hematopoietic stem cell engraftment in the bone marrow. Plays a role in hematopoiesis; required for normal numbers of hematopoietic stem cells in bone marrow. Promotes in vitro osteoblast proliferation and differentiation (By similarity). Promotes neurite extension, axon growth and axon guidance; axons grow preferentially on surfaces that contain ALCAM. Mediates outgrowth and pathfinding for retinal ganglion cell axons (By similarity)
Protein Sequence
10
MESKGASSCR
20
LLFCLLISAT
30
VFRPGLGWYT
40
VNSAYGDTII
50
IPCRLDVPQN
60
LMFGKWKYEK
70
PDGSPVFIAF
80
RSSTKKSVQY
90
DDVPEYKDRL
100
NLSENYTLSI
110
SNARISDEKR
120
FVCMLVTEDN
130
VFEAPTIVKV
140
FKQPSKPEIV
150
SKALFLETEQ
160
LKKLGDCISE
170
DSYPDGNITW
180
YRNGKVLHPL
190
EGAVVIIFKK
200
EMDPVTQLYT
210
MTSTLEYKTT
220
KADIQMPFTC
230
SVTYYGPSGQ
240
KTIHSEQAVF
250
DIYYPTEQVT
260
IQVLPPKNAI
270
KEGDNITLKC
280
LGNGNPPPEE
290
FLFYLPGQPE
300
GIRSSNTYTL
310
TDVRRNATGD
320
YKCSLIDKKS
330
MIASTAITVH
340
YLDLSLNPSG
350
EVTRQIGDAL
360
PVSCTISASR
370
NATVVWMKDN
380
IRLRSSPSFS
390
SLHYQDAGNY
400
VCETALQEVE
410
GLKKRESLTL
420
IVEGKPQIKM
430
TKKTDPSGLS
440
KTIICHVEGF
450
PKPAIQWTIT
460
GSGSVINQTE
470
ESPYINGRYY
480
SKIIISPEEN
490
VTLTCTAENQ
500
LERTVNSLNV
510
SAISIPEHDE
520
ADEISDENRE
530
KVNDQAKLIV
540
GIVVGLLLAA
550
LVAGVVYWLY
560
MKKSKTASKH
570
VNKDLGNMEE
580
NKKLEENNHK
TEA
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0030424 |
axon |
| Cellular Component |
GO:0030425 |
dendrite |
| Cellular Component |
GO:0009897 |
external side of plasma membrane |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Cellular Component |
GO:0005925 |
focal adhesion |
| Cellular Component |
GO:0001772 |
immunological synapse |
| Cellular Component |
GO:0043025 |
neuronal cell body |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0005102 |
signaling receptor binding |
| Biological Process |
GO:0002250 |
adaptive immune response |
| Biological Process |
GO:0048846 |
axon extension involved in axon guidance |
| Biological Process |
GO:0007155 |
cell adhesion |
| Biological Process |
GO:0007157 |
heterophilic cell-cell adhesion |
| Biological Process |
GO:0031175 |
neuron projection development |
| Biological Process |
GO:1990138 |
neuron projection extension |
| Biological Process |
GO:0031290 |
retinal ganglion cell axon guidance |
| Biological Process |
GO:0007165 |
signal transduction |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.