Search Results
Overview
| Uniprot ID | Q13765 |
|---|---|
| Protein Name | Nascent polypeptide-associated complex subunit alpha |
| Gene Name | NACA |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 100 | RVTIRKSKNILFVIT |
| 142 | AQLAAAEKFKVQGEA |
| 144 | LAAAEKFKVQGEAVS |
| 82 | KARKAMSKLGLRQVT |
Function
Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene promoters
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:0003231 | cardiac ventricle development |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005854 | nascent polypeptide-associated complex |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0003713 | transcription coactivator activity |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0061384 | heart trabecula morphogenesis |
| Biological Process | GO:1905551 | negative regulation of protein localization to endoplasmic reticulum |
| Biological Process | GO:0010664 | negative regulation of striated muscle cell apoptotic process |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:2000138 | positive regulation of cell proliferation involved in heart morphogenesis |
| Biological Process | GO:0048633 | positive regulation of skeletal muscle tissue growth |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0015031 | protein transport |
| Biological Process | GO:0048742 | regulation of skeletal muscle fiber development |
| Biological Process | GO:0043403 | skeletal muscle tissue regeneration |
| Biological Process | GO:0006412 | translation |
| Biological Process | GO:0042060 | wound healing |
Reference
[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.
[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.
[3] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.
[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.