Search Results

Overview

Uniprot IDQ13813
Protein NameSpectrin alpha chain, non-erythrocytic 1
Gene NameSPTAN1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1023 VPAAYVKKLDPAQSA
1057 DNQTRITKEAGSVSL
1132 QVEVLQKKFDDFQKD
1187 PRDETDSKTASPWKS
1193 SKTASPWKSARLMVH
1274 SVQALQRKHEGFERD
1288 DLAALGDKVNSLGET
1334 RADQRKAKLGDSHDL
1419 ASPEIKQKLDILDQE
144 KMREKGIKLLQAQKL
1537 LDRWRRLKAQMIEKR
1580 TASDESYKDPTNIQS
1588 DPTNIQSKHQKHQAF
1591 NIQSKHQKHQAFEAE
1630 AGSEDAVKARLAALA
1659 QKLKEANKQQNFNTG
1698 ASVNNLLKKHQLLEA
1699 SVNNLLKKHQLLEAD
1759 MAASRRAKLNESHRL
1781 DDEESWIKEKKLLVG
1784 ESWIKEKKLLVGSED
1828 QGVLDTGKKLSDDNT
1838 SDDNTIGKEEIQQRL
1853 AQFVEHWKELKQLAA
1856 VEHWKELKQLAAARG
189 EHVEVLQKKFEEFQT
190 HVEVLQKKFEEFQTD
1911 AIQGLLKKHEAFETD
1923 ETDFTVHKDRVNDVC
1963 GKVSDLEKAAAQRKA
2000 GEKENSLKTDDYGRD
2047 KDQLLAAKHVQSKAI
2052 AAKHVQSKAIEARHA
2063 ARHASLMKRWSQLLA
2078 NSAARKKKLLEAQSH
2088 EAQSHFRKVEDLFLT
214 EVNQFAAKLIQEQHP
2184 ETWRNLQKIIKEREL
229 EEELIKTKQDEVNAA
241 NAAWQRLKGLALQRQ
2421 RALSSEGKPYVTKEE
2426 EGKPYVTKEELYQNL
2452 MKPYVDGKGRELPTA
250 LALQRQGKLFGAAEV
272 DETISWIKEKEQLMA
274 TISWIKEKEQLMASD
296 SVQALLRKHEGLERD
30 LDRYHRFKELSTLRR
312 AALEDKVKALCAEAD
335 SATQIQVKREELITN
39 LSTLRRQKLEDSYRF
407 LDRHQEHKGEIDAHE
441 ASDEVREKLTVLSEE
522 SLSAQEEKITALDEF
594 SWVNEKMKTATDEAY
602 TATDEAYKDPSNLQG
610 DPSNLQGKVQKHQAF
613 NLQGKVQKHQAFEAE
633 SRIDALEKAGQKLID
637 ALEKAGQKLIDVNHY
646 IDVNHYAKDEVAARM
661 NEVISLWKKLLEATE
662 EVISLWKKLLEATEL
670 LLEATELKGIKLREA
718 TNVQNLQKKHALLEA
719 NVQNLQKKHALLEAD
73 IASDENYKDPTNLQG
758 DAENIKKKQEALVAR
779 PMVARKQKLADSLRL
81 DPTNLQGKLQKHQAF
814 AASTNRGKDLIGVQN
824 IGVQNLLKKHQALQA
825 GVQNLLKKHQALQAE
84 NLQGKLQKHQAFEAE
846 RIKAVTQKGNAMVEE
864 AAEDVKAKLHELNQK
871 KLHELNQKWEALKAK
931 SAEALLKKHEALMSD
990 PREVTMKKGDILTLL

Function

Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane

Protein Sequence

10 MDPSGVKVLE 20 TAEDIQERRQ 30 QVLDRYHRFK 40 ELSTLRRQKL 50 EDSYRFQFFQ 60 RDAEELEKWI 70 QEKLQIASDE 80 NYKDPTNLQG 90 KLQKHQAFEA 100 EVQANSGAIV 110 KLDETGNLMI 120 SEGHFASETI 130 RTRLMELHRQ 140 WELLLEKMRE 150 KGIKLLQAQK 160 LVQYLRECED 170 VMDWINDKEA 180 IVTSEELGQD 190 LEHVEVLQKK 200 FEEFQTDMAA 210 HEERVNEVNQ 220 FAAKLIQEQH 230 PEEELIKTKQ 240 DEVNAAWQRL 250 KGLALQRQGK 260 LFGAAEVQRF 270 NRDVDETISW 280 IKEKEQLMAS 290 DDFGRDLASV 300 QALLRKHEGL 310 ERDLAALEDK 320 VKALCAEADR 330 LQQSHPLSAT 340 QIQVKREELI 350 TNWEQIRTLA 360 AERHARLNDS 370 YRLQRFLADF 380 RDLTSWVTEM 390 KALINADELA 400 SDVAGAEALL 410 DRHQEHKGEI 420 DAHEDSFKSA 430 DESGQALLAA 440 GHYASDEVRE 450 KLTVLSEERA 460 ALLELWELRR 470 QQYEQCMDLQ 480 LFYRDTEQVD 490 NWMSKQEAFL 500 LNEDLGDSLD 510 SVEALLKKHE 520 DFEKSLSAQE 530 EKITALDEFA 540 TKLIQNNHYA 550 MEDVATRRDA 560 LLSRRNALHE 570 RAMRRRAQLA 580 DSFHLQQFFR 590 DSDELKSWVN 600 EKMKTATDEA 610 YKDPSNLQGK 620 VQKHQAFEAE 630 LSANQSRIDA 640 LEKAGQKLID 650 VNHYAKDEVA 660 ARMNEVISLW 670 KKLLEATELK 680 GIKLREANQQ 690 QQFNRNVEDI 700 ELWLYEVEGH 710 LASDDYGKDL 720 TNVQNLQKKH 730 ALLEADVAAH 740 QDRIDGITIQ 750 ARQFQDAGHF 760 DAENIKKKQE 770 ALVARYEALK 780 EPMVARKQKL 790 ADSLRLQQLF 800 RDVEDEETWI 810 REKEPIAAST 820 NRGKDLIGVQ 830 NLLKKHQALQ 840 AEIAGHEPRI 850 KAVTQKGNAM 860 VEEGHFAAED 870 VKAKLHELNQ 880 KWEALKAKAS 890 QRRQDLEDSL 900 QAQQYFADAN 910 EAESWMREKE 920 PIVGSTDYGK 930 DEDSAEALLK 940 KHEALMSDLS 950 AYGSSIQALR 960 EQAQSCRQQV 970 APTDDETGKE 980 LVLALYDYQE 990 KSPREVTMKK 1000 GDILTLLNST 1010 NKDWWKVEVN 1020 DRQGFVPAAY 1030 VKKLDPAQSA 1040 SRENLLEEQG 1050 SIALRQEQID 1060 NQTRITKEAG 1070 SVSLRMKQVE 1080 ELYHSLLELG 1090 EKRKGMLEKS 1100 CKKFMLFREA 1110 NELQQWINEK 1120 EAALTSEEVG 1130 ADLEQVEVLQ 1140 KKFDDFQKDL 1150 KANESRLKDI 1160 NKVAEDLESE 1170 GLMAEEVQAV 1180 QQQEVYGMMP 1190 RDETDSKTAS 1200 PWKSARLMVH 1210 TVATFNSIKE 1220 LNERWRSLQQ 1230 LAEERSQLLG 1240 SAHEVQRFHR 1250 DADETKEWIE 1260 EKNQALNTDN 1270 YGHDLASVQA 1280 LQRKHEGFER 1290 DLAALGDKVN 1300 SLGETAERLI 1310 QSHPESAEDL 1320 QEKCTELNQA 1330 WSSLGKRADQ 1340 RKAKLGDSHD 1350 LQRFLSDFRD 1360 LMSWINGIRG 1370 LVSSDELAKD 1380 VTGAEALLER 1390 HQEHRTEIDA 1400 RAGTFQAFEQ 1410 FGQQLLAHGH 1420 YASPEIKQKL 1430 DILDQERADL 1440 EKAWVQRRMM 1450 LDQCLELQLF 1460 HRDCEQAENW 1470 MAAREAFLNT 1480 EDKGDSLDSV 1490 EALIKKHEDF 1500 DKAINVQEEK 1510 IAALQAFADQ 1520 LIAAGHYAKG 1530 DISSRRNEVL 1540 DRWRRLKAQM 1550 IEKRSKLGES 1560 QTLQQFSRDV 1570 DEIEAWISEK 1580 LQTASDESYK 1590 DPTNIQSKHQ 1600 KHQAFEAELH 1610 ANADRIRGVI 1620 DMGNSLIERG 1630 ACAGSEDAVK 1640 ARLAALADQW 1650 QFLVQKSAEK 1660 SQKLKEANKQ 1670 QNFNTGIKDF 1680 DFWLSEVEAL 1690 LASEDYGKDL 1700 ASVNNLLKKH 1710 QLLEADISAH 1720 EDRLKDLNSQ 1730 ADSLMTSSAF 1740 DTSQVKDKRD 1750 TINGRFQKIK 1760 SMAASRRAKL 1770 NESHRLHQFF 1780 RDMDDEESWI 1790 KEKKLLVGSE 1800 DYGRDLTGVQ 1810 NLRKKHKRLE 1820 AELAAHEPAI 1830 QGVLDTGKKL 1840 SDDNTIGKEE 1850 IQQRLAQFVE 1860 HWKELKQLAA 1870 ARGQRLEESL 1880 EYQQFVANVE 1890 EEEAWINEKM 1900 TLVASEDYGD 1910 TLAAIQGLLK 1920 KHEAFETDFT 1930 VHKDRVNDVC 1940 TNGQDLIKKN 1950 NHHEENISSK 1960 MKGLNGKVSD 1970 LEKAAAQRKA 1980 KLDENSAFLQ 1990 FNWKADVVES 2000 WIGEKENSLK 2010 TDDYGRDLSS 2020 VQTLLTKQET 2030 FDAGLQAFQQ 2040 EGIANITALK 2050 DQLLAAKHVQ 2060 SKAIEARHAS 2070 LMKRWSQLLA 2080 NSAARKKKLL 2090 EAQSHFRKVE 2100 DLFLTFAKKA 2110 SAFNSWFENA 2120 EEDLTDPVRC 2130 NSLEEIKALR 2140 EAHDAFRSSL 2150 SSAQADFNQL 2160 AELDRQIKSF 2170 RVASNPYTWF 2180 TMEALEETWR 2190 NLQKIIKERE 2200 LELQKEQRRQ 2210 EENDKLRQEF 2220 AQHANAFHQW 2230 IQETRTYLLD 2240 GSCMVEESGT 2250 LESQLEATKR 2260 KHQEIRAMRS 2270 QLKKIEDLGA 2280 AMEEALILDN 2290 KYTEHSTVGL 2300 AQQWDQLDQL 2310 GMRMQHNLEQ 2320 QIQARNTTGV 2330 TEEALKEFSM 2340 MFKHFDKDKS 2350 GRLNHQEFKS 2360 CLRSLGYDLP 2370 MVEEGEPDPE 2380 FEAILDTVDP 2390 NRDGHVSLQE 2400 YMAFMISRET 2410 ENVKSSEEIE 2420 SAFRALSSEG 2430 KPYVTKEELY 2440 QNLTREQADY 2450 CVSHMKPYVD 2460 GKGRELPTAF 2470 DYVEFTRSLF VN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030054 cell junction
Cellular Component GO:0042995 cell projection
Cellular Component GO:0030864 cortical actin cytoskeleton
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005576 extracellular region
Cellular Component GO:1903561 extracellular vesicle
Cellular Component GO:0016020 membrane
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0035580 specific granule lumen
Cellular Component GO:0008091 spectrin
Cellular Component GO:1904724 tertiary granule lumen
Molecular Function GO:0003779 actin binding
Molecular Function GO:0051015 actin filament binding
Molecular Function GO:0045296 cadherin binding
Molecular Function GO:0005509 calcium ion binding
Molecular Function GO:0005516 calmodulin binding
Molecular Function GO:0005200 structural constituent of cytoskeleton
Biological Process GO:0030036 actin cytoskeleton organization
Biological Process GO:0051693 actin filament capping

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[4] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[5] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[6] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[7] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[8] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.