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Overview

Uniprot ID	Q13823
Protein Name	Nucleolar GTP-binding protein 2
Gene Name	GNL2
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
16	RSTINPSKASTNPDR
598	NDTKAVIKALDEKIA
609	EKIAKYQKFLDKAKA
655	DDRAPSKKGKKRKAQ
705	YYETHNVKNRNRNKK
88	FGNTRVIKQSSLQKF

Function

GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation (PubMed:32669547). May promote cell proliferation possibly by increasing p53/TP53 protein levels, and consequently those of its downstream product CDKN1A/p21, and decreasing RPL23A protein levels (PubMed:26203195)

Protein Sequence

10 MVKPKYKGRS 20 TINPSKASTN 30 PDRVQGAGGQ 40 NMRDRATIRR 50 LNMYRQKERR 60 NSRGKIIKPL 70 QYQSTVASGT 80 VARVEPNIKW 90 FGNTRVIKQS 100 SLQKFQEEMD 110 TVMKDPYKVV 120 MKQSKLPMSL 130 LHDRIRPHNL 140 KVHILDTESF 150 ETTFGPKSQR 160 KRPNLFASDM 170 QSLIENAEMS 180 TESYDQGKDR 190 DLVTEDTGVR 200 NEAQEEIYKK 210 GQSKRIWGEL 220 YKVIDSSDVV 230 VQVLDARDPM 240 GTRSPHIETY 250 LKKEKPWKHL 260 IFVLNKCDLV 270 PTWATKRWVA 280 VLSQDYPTLA 290 FHASLTNPFG 300 KGAFIQLLRQ 310 FGKLHTDKKQ 320 ISVGFIGYPN 330 VGKSSVINTL 340 RSKKVCNVAP 350 IAGETKVWQY 360 ITLMRRIFLI 370 DCPGVVYPSE 380 DSETDIVLKG 390 VVQVEKIKSP 400 EDHIGAVLER 410 AKPEYISKTY 420 KIDSWENAED 430 FLEKLAFRTG 440 KLLKGGEPDL 450 QTVGKMVLND 460 WQRGRIPFFV 470 KPPNAEPLVA 480 PQLLPSSSLE 490 VVPEAAQNNP 500 GEEVTETAGE 510 GSESIIKEET 520 EENSHCDANT 530 EMQQILTRVR 540 QNFGKINVVP 550 QFSGDDLVPV 560 EVSDLEEELE 570 SFSDEEEEEQ 580 EQQRDDAEES 590 SSEPEEENVG 600 NDTKAVIKAL 610 DEKIAKYQKF 620 LDKAKAKKFS 630 AVRISKGLSE 640 KIFAKPEEQR 650 KTLEEDVDDR 660 APSKKGKKRK 670 AQREEEQEHS 680 NKAPRALTSK 690 ERRRAVRQQR 700 PKKVGVRYYE 710 THNVKNRNRN 720 KKKTNDSEGQ 730 KHKRKKFRQK Q

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0005730	nucleolus
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0005525	GTP binding
Molecular Function	GO:0003924	GTPase activity
Molecular Function	GO:0003723	RNA binding
Biological Process	GO:0042254	ribosome biogenesis

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.