Search Results
Overview
| Uniprot ID | Q13867 |
|---|---|
| Protein Name | Bleomycin hydrolase |
| Gene Name | BLMH |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 163 | KYGVIPKKCFPESYT |
| 297 | SNMVGGRKTLYNNQP |
| 309 | NQPIDFLKKMVAASI |
| 42 | DLLDICLKRATVQRA |
Function
The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B-aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity
Protein Sequence
10
MSSSGLNSEK
20
VAALIQKLNS
30
DPQFVLAQNV
40
GTTHDLLDIC
50
LKRATVQRAQ
60
HVFQHAVPQE
70
GKPITNQKSS
80
GRCWIFSCLN
90
VMRLPFMKKL
100
NIEEFEFSQS
110
YLFFWDKVER
120
CYFFLSAFVD
130
TAQRKEPEDG
140
RLVQFLLMNP
150
ANDGGQWDML
160
VNIVEKYGVI
170
PKKCFPESYT
180
TEATRRMNDI
190
LNHKMREFCI
200
RLRNLVHSGA
210
TKGEISATQD
220
VMMEEIFRVV
230
CICLGNPPET
240
FTWEYRDKDK
250
NYQKIGPITP
260
LEFYREHVKP
270
LFNMEDKICL
280
VNDPRPQHKY
290
NKLYTVEYLS
300
NMVGGRKTLY
310
NNQPIDFLKK
320
MVAASIKDGE
330
AVWFGCDVGK
340
HFNSKLGLSD
350
MNLYDHELVF
360
GVSLKNMNKA
370
ERLTFGESLM
380
THAMTFTAVS
390
EKDDQDGAFT
400
KWRVENSWGE
410
DHGHKGYLCM
420
TDEWFSEYVY
430
EVVVDRKHVP
440
EEVLAVLEQE
450
PIILPAWDPM
GALAE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0004177 | aminopeptidase activity |
| Molecular Function | GO:0004180 | carboxypeptidase activity |
| Molecular Function | GO:0070005 | cysteine-type aminopeptidase activity |
| Molecular Function | GO:0004197 | cysteine-type endopeptidase activity |
| Molecular Function | GO:0008234 | cysteine-type peptidase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Biological Process | GO:0043418 | homocysteine catabolic process |
| Biological Process | GO:0000209 | protein polyubiquitination |
| Biological Process | GO:0006508 | proteolysis |
| Biological Process | GO:0009636 | response to toxic substance |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.