Overview
| Uniprot ID | Q13868 |
|---|
| Protein Name | Exosome complex component RRP4 |
|---|
| Gene Name | EXOSC2 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 65 |
GSVERVNKLICVKAL |
Function
Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC2 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC4 and EXOSC7
Protein Sequence
10
MAMEMRLPVA
20
RKPLSERLGR
30
DTKKHLVVPG
40
DTITTDTGFM
50
RGHGTYMGEE
60
KLIASVAGSV
70
ERVNKLICVK
80
ALKTRYIGEV
90
GDIVVGRITE
100
VQQKRWKVET
110
NSRLDSVLLL
120
SSMNLPGGEL
130
RRRSAEDELA
140
MRGFLQEGDL
150
ISAEVQAVFS
160
DGAVSLHTRS
170
LKYGKLGQGV
180
LVQVSPSLVK
190
RQKTHFHDLP
200
CGASVILGNN
210
GFIWIYPTPE
220
HKEEEAGGFI
230
ANLEPVSLAD
240
REVISRLRNC
250
IISLVTQRMM
260
LYDTSILYCY
270
EASLPHQIKD
280
ILKPEIMEEI
290
VMETRQRLLE
QEG
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0000177 |
cytoplasmic exosome (RNase complex) |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0000178 |
exosome (RNase complex) |
| Cellular Component |
GO:0000176 |
nuclear exosome (RNase complex) |
| Cellular Component |
GO:0005730 |
nucleolus |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0000175 |
3'-5'-RNA exonuclease activity |
| Molecular Function |
GO:0008312 |
7S RNA binding |
| Molecular Function |
GO:0003723 |
RNA binding |
| Biological Process |
GO:0071034 |
CUT catabolic process |
| Biological Process |
GO:0000467 |
exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
| Biological Process |
GO:0071035 |
nuclear polyadenylation-dependent rRNA catabolic process |
| Biological Process |
GO:0000956 |
nuclear-transcribed mRNA catabolic process |
| Biological Process |
GO:0071051 |
poly(A)-dependent snoRNA 3'-end processing |
| Biological Process |
GO:0030307 |
positive regulation of cell growth |
| Biological Process |
GO:0006401 |
RNA catabolic process |
| Biological Process |
GO:0006396 |
RNA processing |
| Biological Process |
GO:0006364 |
rRNA processing |
| Biological Process |
GO:0071038 |
TRAMP-dependent tRNA surveillance pathway |
| Biological Process |
GO:0034475 |
U4 snRNA 3'-end processing |
Reference
PMID: N/A