Search Results

Overview

Uniprot ID	Q13884
Protein Name	Beta-1-syntrophin
Gene Name	SNTB1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
181	DEAVQALKRAGKEVL
314	EVREQLGKTGIAGSR
387	LVHSGPGKGSPQAGV

Function

Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex

Protein Sequence

10 MAVAAAAAAA 20 GPAGAGGGRA 30 QRSGLLEVLV 40 RDRWHKVLVN 50 LSEDALVLSS 60 EEGAAAYNGI 70 GTATNGSFCR 80 GAGAGHPGAG 90 GAQPPDSPAG 100 VRTAFTDLPE 110 QVPESISNQK 120 RGVKVLKQEL 130 GGLGISIKGG 140 KENKMPILIS 150 KIFKGLAADQ 160 TQALYVGDAI 170 LSVNGADLRD 180 ATHDEAVQAL 190 KRAGKEVLLE 200 VKYMREATPY 210 VKKGSPVSEI 220 GWETPPPESP 230 RLGGSTSDPP 240 SSQSFSFHRD 250 RKSIPLKMCY 260 VTRSMALADP 270 ENRQLEIHSP 280 DAKHTVILRS 290 KDSATAQAWF 300 SAIHSNVNDL 310 LTRVIAEVRE 320 QLGKTGIAGS 330 REIRHLGWLA 340 EKVPGESKKQ 350 WKPALVVLTE 360 KDLLIYDSMP 370 RRKEAWFSPV 380 HTYPLLATRL 390 VHSGPGKGSP 400 QAGVDLSFAT 410 RTGTRQGIET 420 HLFRAETSRD 430 LSHWTRSIVQ 440 GCHNSAELIA 450 EISTACTYKN 460 QECRLTIHYE 470 NGFSITTEPQ 480 EGAFPKTIIQ 490 SPYEKLKMSS 500 DDGIRMLYLD 510 FGGKDGEIQL 520 DLHSCPKPIV 530 FIIHSFLSAK ITRLGLVA

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005856	cytoskeleton
Cellular Component	GO:0016010	dystrophin-associated glycoprotein complex
Cellular Component	GO:0005925	focal adhesion
Cellular Component	GO:0031594	neuromuscular junction
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0032991	protein-containing complex
Cellular Component	GO:0042383	sarcolemma
Cellular Component	GO:0045202	synapse
Molecular Function	GO:0003779	actin binding
Molecular Function	GO:0005516	calmodulin binding
Molecular Function	GO:0030165	PDZ domain binding
Molecular Function	GO:0005198	structural molecule activity
Biological Process	GO:0043010	camera-type eye development
Biological Process	GO:0006936	muscle contraction

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.