Overview
| Uniprot ID | Q13889 |
|---|
| Protein Name | General transcription factor IIH subunit 3 |
|---|
| Gene Name | GTF2H3 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 298 |
ISLPPVLKAKKKKLK |
| 300 |
LPPVLKAKKKKLKVS |
Function
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription
Protein Sequence
10
MVSDEDELNL
20
LVIVVDANPI
30
WWGKQALKES
40
QFTLSKCIDA
50
VMVLGNSHLF
60
MNRSNKLAVI
70
ASHIQESRFL
80
YPGKNGRLGD
90
FFGDPGNPPE
100
FNPSGSKDGK
110
YELLTSANEV
120
IVEEIKDLMT
130
KSDIKGQHTE
140
TLLAGSLAKA
150
LCYIHRMNKE
160
VKDNQEMKSR
170
ILVIKAAEDS
180
ALQYMNFMNV
190
IFAAQKQNIL
200
IDACVLDSDS
210
GLLQQACDIT
220
GGLYLKVPQM
230
PSLLQYLLWV
240
FLPDQDQRSQ
250
LILPPPVHVD
260
YRAACFCHRN
270
LIEIGYVCSV
280
CLSIFCNFSP
290
ICTTCETAFK
300
ISLPPVLKAK
KKKLKVSA
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0000438 |
core TFIIH complex portion of holo TFIIH complex |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0005669 |
transcription factor TFIID complex |
| Cellular Component |
GO:0000439 |
transcription factor TFIIH core complex |
| Cellular Component |
GO:0005675 |
transcription factor TFIIH holo complex |
| Cellular Component |
GO:0097550 |
transcription preinitiation complex |
| Molecular Function |
GO:0016251 |
RNA polymerase II general transcription initiation factor activity |
| Molecular Function |
GO:0008270 |
zinc ion binding |
| Biological Process |
GO:0006281 |
DNA repair |
| Biological Process |
GO:0006289 |
nucleotide-excision repair |
| Biological Process |
GO:0006355 |
regulation of DNA-templated transcription |
| Biological Process |
GO:0006366 |
transcription by RNA polymerase II |
| Biological Process |
GO:0006367 |
transcription initiation at RNA polymerase II promoter |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.