Search Results
Overview
| Uniprot ID | Q13901 |
|---|---|
| Protein Name | Nuclear nucleic acid-binding protein C1D |
| Gene Name | C1D |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 119 | GAASRFVKNALWEPK |
| 128 | ALWEPKSKNASKVAN |
Function
Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB (By similarity)
Protein Sequence
10
MAGEEINEDY
20
PVEIHEYLSA
30
FENSIGAVDE
40
MLKTMMSVSR
50
NELLQKLDPL
60
EQAKVDLVSA
70
YTLNSMFWVY
80
LATQGVNPKE
90
HPVKQELERI
100
RVYMNRVKEI
110
TDKKKAGKLD
120
RGAASRFVKN
130
ALWEPKSKNA
140
SKVANKGKSK
S
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0000178 | exosome (RNase complex) |
| Cellular Component | GO:0000176 | nuclear exosome (RNase complex) |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0017053 | transcription repressor complex |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0016922 | nuclear receptor binding |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0003714 | transcription corepressor activity |
| Biological Process | GO:0006915 | apoptotic process |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0000460 | maturation of 5.8S rRNA |
| Biological Process | GO:0010468 | regulation of gene expression |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.