Search Results
Overview
| Uniprot ID | Q13905 |
|---|---|
| Protein Name | Rap guanine nucleotide exchange factor 1 |
| Gene Name | RAPGEF1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 640 | AVSGVPGKDSRDGSE |
Function
Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1 (PubMed:12432078). Plays a role in the establishment of basal endothelial barrier function. Plays a role in nerve growth factor (NGF)-induced sustained activation of Rap1 and neurite outgrowth
Protein Sequence
10
MDTDSQRSHL
20
SSFTMKLMDK
30
FHSPKIKRTP
40
SKKGKPAEVS
50
VKIPEKPVNK
60
EATDRFLPEG
70
YPLPLDLEQQ
80
AVEFMSTSAV
90
ASRSQRQKNL
100
SWLEEKEKEV
110
VSALRYFKTI
120
VDKMAIDKKV
130
LEMLPGSASK
140
VLEAILPLVQ
150
NDPRIQHSSA
160
LSSCYSRVYQ
170
SLANLIRWSD
180
QVMLEGVNSE
190
DKEMVTTVKG
200
VIKAVLDGVK
210
ELVRLTIEKQ
220
GRPSPTSPVK
230
PSSPASKPDG
240
PAELPLTDRE
250
VEILNKTTGM
260
SQSTELLPDA
270
TDEEVAPPKP
280
PLPGIRVVDN
290
SPPPALPPKK
300
RQSAPSPTRV
310
AVVAPMSRAT
320
SGSSLPVGIN
330
RQDFDVDCYA
340
QRRLSGGSHS
350
YGGESPRLSP
360
CSSIGKLSKS
370
DEQLSSLDRD
380
SGQCSRNTSC
390
ETLDHYDPDY
400
EFLQQDLSNA
410
DQIPQQTAWN
420
LSPLPESLGE
430
SGSPFLGPPF
440
QLPLGGHPQP
450
DGPLAPGQQT
460
DTPPALPEKK
470
RRSAASQTAD
480
GSGCRVSYER
490
HPSQYDNISG
500
EDLQSTAPIP
510
SVPYAPFAAI
520
LPFQHGGSSA
530
PVEFVGDFTA
540
PESTGDPEKP
550
PPLPEKKNKH
560
MLAYMQLLED
570
YSEPQPSMFY
580
QTPQNEHIYQ
590
QKNKLLMEVY
600
GFSDSFSGVD
610
SVQELAPPPA
620
LPPKQRQLEP
630
PAGKDGHPRD
640
PSAVSGVPGK
650
DSRDGSERAP
660
KSPDALESAQ
670
SEEEVDELSL
680
IDHNEIMSRL
690
TLKQEGDDGP
700
DVRGGSGDIL
710
LVHATETDRK
720
DLVLYCEAFL
730
TTYRTFISPE
740
ELIKKLQYRY
750
EKFSPFADTF
760
KKRVSKNTFF
770
VLVRVVDELC
780
LVELTEEILK
790
LLMELVFRLV
800
CNGELSLARV
810
LRKNILDKVD
820
QKKLLRCATS
830
SQPLAARGVA
840
ARPGTLHDFH
850
SHEIAEQLTL
860
LDAELFYKIE
870
IPEVLLWAKE
880
QNEEKSPNLT
890
QFTEHFNNMS
900
YWVRSIIMLQ
910
EKAQDRERLL
920
LKFIKIMKHL
930
RKLNNFNSYL
940
AILSALDSAP
950
IRRLEWQKQT
960
SEGLAEYCTL
970
IDSSSSFRAY
980
RAALSEVEPP
990
CIPYLGLILQ
1000
DLTFVHLGNP
1010
DYIDGKVNFS
1020
KRWQQFNILD
1030
SMRCFQQAHY
1040
DMRRNDDIIN
1050
FFNDFSDHLA
1060
EEALWELSLK
1070
IKPRNITRRK
TDREEKT
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005769 | early endosome |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0005085 | guanyl-nucleotide exchange factor activity |
| Molecular Function | GO:0017124 | SH3 domain binding |
| Biological Process | GO:0007169 | cell surface receptor protein tyrosine kinase signaling pathway |
| Biological Process | GO:0071320 | cellular response to cAMP |
| Biological Process | GO:1990090 | cellular response to nerve growth factor stimulus |
| Biological Process | GO:0061028 | establishment of endothelial barrier |
| Biological Process | GO:0038180 | nerve growth factor signaling pathway |
| Biological Process | GO:0007399 | nervous system development |
| Biological Process | GO:0043547 | positive regulation of GTPase activity |
| Biological Process | GO:0010976 | positive regulation of neuron projection development |
| Biological Process | GO:0032486 | Rap protein signal transduction |
| Biological Process | GO:0007265 | Ras protein signal transduction |
| Biological Process | GO:1901888 | regulation of cell junction assembly |
| Biological Process | GO:0007165 | signal transduction |
Reference
[1] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.