Search Results
Overview
| Uniprot ID | Q13907 |
|---|---|
| Protein Name | Isopentenyl-diphosphate Delta-isomerase 1 |
| Gene Name | IDI1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 157 | DYILLVRKNVTLNPD |
| 36 | NKIGAETKKNCHLNE |
Function
Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
Protein Sequence
10
MPEINTNHLD
20
KQQVQLLAEM
30
CILIDENDNK
40
IGAETKKNCH
50
LNENIEKGLL
60
HRAFSVFLFN
70
TENKLLLQQR
80
SDAKITFPGC
90
FTNTCCSHPL
100
SNPAELEESD
110
ALGVRRAAQR
120
RLKAELGIPL
130
EEVPPEEINY
140
LTRIHYKAQS
150
DGIWGEHEID
160
YILLVRKNVT
170
LNPDPNEIKS
180
YCYVSKEELK
190
ELLKKAASGE
200
IKITPWFKII
210
AATFLFKWWD
220
NLNHLNQFVD
HEKIYRM
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005777 | peroxisome |
| Molecular Function | GO:0004452 | isopentenyl-diphosphate delta-isomerase activity |
| Molecular Function | GO:0000287 | magnesium ion binding |
| Molecular Function | GO:0030145 | manganese ion binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Biological Process | GO:0006695 | cholesterol biosynthetic process |
| Biological Process | GO:0033489 | cholesterol biosynthetic process via desmosterol |
| Biological Process | GO:0033490 | cholesterol biosynthetic process via lathosterol |
| Biological Process | GO:0050992 | dimethylallyl diphosphate biosynthetic process |
| Biological Process | GO:0010142 | farnesyl diphosphate biosynthetic process, mevalonate pathway |
| Biological Process | GO:0033386 | geranylgeranyl diphosphate biosynthetic process |
| Biological Process | GO:0009240 | isopentenyl diphosphate biosynthetic process |
| Biological Process | GO:0008299 | isoprenoid biosynthetic process |
| Biological Process | GO:0035634 | response to stilbenoid |
| Biological Process | GO:0036197 | zymosterol biosynthetic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.