Search Results

Overview

Uniprot IDQ14004
Protein NameCyclin-dependent kinase 13
Gene NameCDK13
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1029 SKKRRRQKQMGMTDD
1045 STIKAPRKDLSLGLD
455 SLAAELNKNKKARAA
457 AAELNKNKKARAAEA
513 ASQTNHVKDVKKIKI
519 VKDVKKIKIEHAPSP
560 IVDKATKKAVIVGKE

Function

Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef

Protein Sequence

10 MPSSSDTALG 20 GGGGLSWAEK 30 KLEERRKRRR 40 FLSPQQPPLL 50 LPLLQPQLLQ 60 PPPPPPPLLF 70 LAAPGTAAAA 80 AAAAAASSSC 90 FSPGPPLEVK 100 RLARGKRRAG 110 GRQKRRRGPR 120 AGQEAEKRRV 130 FSLPQPQQDG 140 GGGASSGGGV 150 TPLVEYEDVS 160 SQSEQGLLLG 170 GASAATAATA 180 AGGTGGSGGS 190 PASSSGTQRR 200 GEGSERRPRR 210 DRRSSSGRSK 220 ERHREHRRRD 230 GQRGGSEASK 240 SRSRHSHSGE 250 ERAEVAKSGS 260 SSSSGGRRKS 270 ASATSSSSSS 280 RKDRDSKAHR 290 SRTKSSKEPP 300 SAYKEPPKAY 310 REDKTEPKAY 320 RRRRSLSPLG 330 GRDDSPVSHR 340 ASQSLRSRKS 350 PSPAGGGSSP 360 YSRRLPRSPS 370 PYSRRRSPSY 380 SRHSSYERGG 390 DVSPSPYSSS 400 SWRRSRSPYS 410 PVLRRSGKSR 420 SRSPYSSRHS 430 RSRSRHRLSR 440 SRSRHSSISP 450 STLTLKSSLA 460 AELNKNKKAR 470 AAEAARAAEA 480 AKAAEATKAA 490 EAAAKAAKAS 500 NTSTPTKGNT 510 ETSASASQTN 520 HVKDVKKIKI 530 EHAPSPSSGG 540 TLKNDKAKTK 550 PPLQVTKVEN 560 NLIVDKATKK 570 AVIVGKESKS 580 AATKEESVSL 590 KEKTKPLTPS 600 IGAKEKEQHV 610 ALVTSTLPPL 620 PLPPMLPEDK 630 EADSLRGNIS 640 VKAVKKEVEK 650 KLRCLLADLP 660 LPPELPGGDD 670 LSKSPEEKKT 680 ATQLHSKRRP 690 KICGPRYGET 700 KEKDIDWGKR 710 CVDKFDIIGI 720 IGEGTYGQVY 730 KARDKDTGEM 740 VALKKVRLDN 750 EKEGFPITAI 760 REIKILRQLT 770 HQSIINMKEI 780 VTDKEDALDF 790 KKDKGAFYLV 800 FEYMDHDLMG 810 LLESGLVHFN 820 ENHIKSFMRQ 830 LMEGLDYCHK 840 KNFLHRDIKC 850 SNILLNNRGQ 860 IKLADFGLAR 870 LYSSEESRPY 880 TNKVITLWYR 890 PPELLLGEER 900 YTPAIDVWSC 910 GCILGELFTK 920 KPIFQANQEL 930 AQLELISRIC 940 GSPCPAVWPD 950 VIKLPYFNTM 960 KPKKQYRRKL 970 REEFVFIPAA 980 ALDLFDYMLA 990 LDPSKRCTAE 1000 QALQCEFLRD 1010 VEPSKMPPPD 1020 LPLWQDCHEL 1030 WSKKRRRQKQ 1040 MGMTDDVSTI 1050 KAPRKDLSLG 1060 LDDSRTNTPQ 1070 GVLPSSQLKS 1080 QGSSNVAPVK 1090 TGPGQHLNHS 1100 ELAILLNLLQ 1110 SKTSVNMADF 1120 VQVLNIKVNS 1130 ETQQQLNKIN 1140 LPAGILATGE 1150 KQTDPSTPQQ 1160 ESSKPLGGIQ 1170 PSSQTIQPKV 1180 ETDAAQAAVQ 1190 SAFAVLLTQL 1200 IKAQQSKQKD 1210 VLLEERENGS 1220 GHEASLQLRP 1230 PPEPSTPVSG 1240 QDDLIQHQDM 1250 RILELTPEPD 1260 RPRILPPDQR 1270 PPEPPEPPPV 1280 TEEDLDYRTE 1290 NQHVPTTSSS 1300 LTDPHAGVKA 1310 ALLQLLAQHQ 1320 PQDDPKREGG 1330 IDYQAGDTYV 1340 STSDYKDNFG 1350 SSSFSSAPYV 1360 SNDGLGSSSA 1370 PPLERRSFIG 1380 NSDIQSLDNY 1390 STASSHSGGP 1400 PQPSAFSESF 1410 PSSVAGYGDI 1420 YLNAGPMLFS 1430 GDKDHRFEYS 1440 HGPIAVLANS 1450 SDPSTGPEST 1460 HPLPAKMHNY 1470 NYGGNLQENP 1480 SGPSLMHGQT 1490 WTSPAQGPGY 1500 SQGYRGHIST 1510 STGRGRGRGL PY

Gene Ontology

Classification GO ID Description
Cellular Component GO:0002945 cyclin K-CDK13 complex
Cellular Component GO:0008024 cyclin/CDK positive transcription elongation factor complex
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0005615 extracellular space
Cellular Component GO:1904813 ficolin-1-rich granule lumen
Cellular Component GO:0019908 nuclear cyclin-dependent protein kinase holoenzyme complex
Cellular Component GO:0016607 nuclear speck
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0030332 cyclin binding
Molecular Function GO:0004693 cyclin-dependent protein serine/threonine kinase activity
Molecular Function GO:0004672 protein kinase activity
Molecular Function GO:0019901 protein kinase binding
Molecular Function GO:0106310 protein serine kinase activity
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity
Biological Process GO:0000380 alternative mRNA splicing, via spliceosome
Biological Process GO:0030097 hemopoiesis
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0032968 positive regulation of transcription elongation by RNA polymerase II
Biological Process GO:0009966 regulation of signal transduction

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.