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Overview

Uniprot IDQ14005
Protein NamePro-interleukin-16
Gene NameIL16
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
857 GSSQLPDKGAQRLSL

Function

Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4

Protein Sequence

10 MESHSRAGKS 20 RKSAKFRSIS 30 RSLMLCNAKT 40 SDDGSSPDEK 50 YPDPFEISLA 60 QGKEGIFHSS 70 VQLADTSEAG 80 PSSVPDLALA 90 SEAAQLQAAG 100 NDRGKTCRRI 110 FFMKESSTAS 120 SREKPGKLEA 130 QSSNFLFPKA 140 CHQRARSNST 150 SVNPYCTREI 160 DFPMTKKSAA 170 PTDRQPYSLC 180 SNRKSLSQQL 190 DCPAGKAAGT 200 SRPTRSLSTA 210 QLVQPSGGLQ 220 ASVISNIVLM 230 KGQAKGLGFS 240 IVGGKDSIYG 250 PIGIYVKTIF 260 AGGAAAADGR 270 LQEGDEILEL 280 NGESMAGLTH 290 QDALQKFKQA 300 KKGLLTLTVR 310 TRLTAPPSLC 320 SHLSPPLCRS 330 LSSSTCITKD 340 SSSFALESPS 350 APISTAKPNY 360 RIMVEVSLQK 370 EAGVGLGIGL 380 CSVPYFQCIS 390 GIFVHTLSPG 400 SVAHLDGRLR 410 CGDEIVEISD 420 SPVHCLTLNE 430 VYTILSHCDP 440 GPVPIIVSRH 450 PDPQVSEQQL 460 KEAVAQAVEN 470 TKFGKERHQW 480 SLEGVKRLES 490 SWHGRPTLEK 500 EREKNSAPPH 510 RRAQKVMIRS 520 SSDSSYMSGS 530 PGGSPGSGSA 540 EKPSSDVDIS 550 THSPSLPLAR 560 EPVVLSIASS 570 RLPQESPPLP 580 ESRDSHPPLR 590 LKKSFEILVR 600 KPMSSKPKPP 610 PRKYFKSDSD 620 PQKSLEEREN 630 SSCSSGHTPP 640 TCGQEARELL 650 PLLLPQEDTA 660 GRSPSASAGC 670 PGPGIGPQTK 680 SSTEGEPGWR 690 RASPVTQTSP 700 IKHPLLKRQA 710 RMDYSFDTTA 720 EDPWVRISDC 730 IKNLFSPIMS 740 ENHGHMPLQP 750 NASLNEEEGT 760 QGHPDGTPPK 770 LDTANGTPKV 780 YKSADSSTVK 790 KGPPVAPKPA 800 WFRQSLKGLR 810 NRASDPRGLP 820 DPALSTQPAP 830 ASREHLGSHI 840 RASSSSSSIR 850 QRISSFETFG 860 SSQLPDKGAQ 870 RLSLQPSSGE 880 AAKPLGKHEE 890 GRFSGLLGRG 900 AAPTLVPQQP 910 EQVLSSGSPA 920 ASEARDPGVS 930 ESPPPGRQPN 940 QKTLPPGPDP 950 LLRLLSTQAE 960 ESQGPVLKMP 970 SQRARSFPLT 980 RSQSCETKLL 990 DEKTSKLYSI 1000 SSQVSSAVMK 1010 SLLCLPSSIS 1020 CAQTPCIPKE 1030 GASPTSSSNE 1040 DSAANGSAET 1050 SALDTGFSLN 1060 LSELREYTEG 1070 LTEAKEDDDG 1080 DHSSLQSGQS 1090 VISLLSSEEL 1100 KKLIEEVKVL 1110 DEATLKQLDG 1120 IHVTILHKEE 1130 GAGLGFSLAG 1140 GADLENKVIT 1150 VHRVFPNGLA 1160 SQEGTIQKGN 1170 EVLSINGKSL 1180 KGTTHHDALA 1190 ILRQAREPRQ 1200 AVIVTRKLTP 1210 EAMPDLNSST 1220 DSAASASAAS 1230 DVSVESTAEA 1240 TVCTVTLEKM 1250 SAGLGFSLEG 1260 GKGSLHGDKP 1270 LTINRIFKGA 1280 ASEQSETVQP 1290 GDEILQLGGT 1300 AMQGLTRFEA 1310 WNIIKALPDG 1320 PVTIVIRRKS 1330 LQSKETTAAG DS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0005615 extracellular space
Cellular Component GO:0016607 nuclear speck
Molecular Function GO:0042609 CD4 receptor binding
Molecular Function GO:0005125 cytokine activity
Biological Process GO:0006935 chemotaxis
Biological Process GO:0019221 cytokine-mediated signaling pathway
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0006955 immune response
Biological Process GO:0050930 induction of positive chemotaxis
Biological Process GO:0050729 positive regulation of inflammatory response
Biological Process GO:0032730 positive regulation of interleukin-1 alpha production
Biological Process GO:0032735 positive regulation of interleukin-12 production
Biological Process GO:0032755 positive regulation of interleukin-6 production

Reference

[1] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.