Search Results
Overview
| Uniprot ID | Q14005 |
|---|---|
| Protein Name | Pro-interleukin-16 |
| Gene Name | IL16 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 857 | GSSQLPDKGAQRLSL |
Function
Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4
Protein Sequence
10
MESHSRAGKS
20
RKSAKFRSIS
30
RSLMLCNAKT
40
SDDGSSPDEK
50
YPDPFEISLA
60
QGKEGIFHSS
70
VQLADTSEAG
80
PSSVPDLALA
90
SEAAQLQAAG
100
NDRGKTCRRI
110
FFMKESSTAS
120
SREKPGKLEA
130
QSSNFLFPKA
140
CHQRARSNST
150
SVNPYCTREI
160
DFPMTKKSAA
170
PTDRQPYSLC
180
SNRKSLSQQL
190
DCPAGKAAGT
200
SRPTRSLSTA
210
QLVQPSGGLQ
220
ASVISNIVLM
230
KGQAKGLGFS
240
IVGGKDSIYG
250
PIGIYVKTIF
260
AGGAAAADGR
270
LQEGDEILEL
280
NGESMAGLTH
290
QDALQKFKQA
300
KKGLLTLTVR
310
TRLTAPPSLC
320
SHLSPPLCRS
330
LSSSTCITKD
340
SSSFALESPS
350
APISTAKPNY
360
RIMVEVSLQK
370
EAGVGLGIGL
380
CSVPYFQCIS
390
GIFVHTLSPG
400
SVAHLDGRLR
410
CGDEIVEISD
420
SPVHCLTLNE
430
VYTILSHCDP
440
GPVPIIVSRH
450
PDPQVSEQQL
460
KEAVAQAVEN
470
TKFGKERHQW
480
SLEGVKRLES
490
SWHGRPTLEK
500
EREKNSAPPH
510
RRAQKVMIRS
520
SSDSSYMSGS
530
PGGSPGSGSA
540
EKPSSDVDIS
550
THSPSLPLAR
560
EPVVLSIASS
570
RLPQESPPLP
580
ESRDSHPPLR
590
LKKSFEILVR
600
KPMSSKPKPP
610
PRKYFKSDSD
620
PQKSLEEREN
630
SSCSSGHTPP
640
TCGQEARELL
650
PLLLPQEDTA
660
GRSPSASAGC
670
PGPGIGPQTK
680
SSTEGEPGWR
690
RASPVTQTSP
700
IKHPLLKRQA
710
RMDYSFDTTA
720
EDPWVRISDC
730
IKNLFSPIMS
740
ENHGHMPLQP
750
NASLNEEEGT
760
QGHPDGTPPK
770
LDTANGTPKV
780
YKSADSSTVK
790
KGPPVAPKPA
800
WFRQSLKGLR
810
NRASDPRGLP
820
DPALSTQPAP
830
ASREHLGSHI
840
RASSSSSSIR
850
QRISSFETFG
860
SSQLPDKGAQ
870
RLSLQPSSGE
880
AAKPLGKHEE
890
GRFSGLLGRG
900
AAPTLVPQQP
910
EQVLSSGSPA
920
ASEARDPGVS
930
ESPPPGRQPN
940
QKTLPPGPDP
950
LLRLLSTQAE
960
ESQGPVLKMP
970
SQRARSFPLT
980
RSQSCETKLL
990
DEKTSKLYSI
1000
SSQVSSAVMK
1010
SLLCLPSSIS
1020
CAQTPCIPKE
1030
GASPTSSSNE
1040
DSAANGSAET
1050
SALDTGFSLN
1060
LSELREYTEG
1070
LTEAKEDDDG
1080
DHSSLQSGQS
1090
VISLLSSEEL
1100
KKLIEEVKVL
1110
DEATLKQLDG
1120
IHVTILHKEE
1130
GAGLGFSLAG
1140
GADLENKVIT
1150
VHRVFPNGLA
1160
SQEGTIQKGN
1170
EVLSINGKSL
1180
KGTTHHDALA
1190
ILRQAREPRQ
1200
AVIVTRKLTP
1210
EAMPDLNSST
1220
DSAASASAAS
1230
DVSVESTAEA
1240
TVCTVTLEKM
1250
SAGLGFSLEG
1260
GKGSLHGDKP
1270
LTINRIFKGA
1280
ASEQSETVQP
1290
GDEILQLGGT
1300
AMQGLTRFEA
1310
WNIIKALPDG
1320
PVTIVIRRKS
1330
LQSKETTAAG
DS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0016607 | nuclear speck |
| Molecular Function | GO:0042609 | CD4 receptor binding |
| Molecular Function | GO:0005125 | cytokine activity |
| Biological Process | GO:0006935 | chemotaxis |
| Biological Process | GO:0019221 | cytokine-mediated signaling pathway |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0006955 | immune response |
| Biological Process | GO:0050930 | induction of positive chemotaxis |
| Biological Process | GO:0050729 | positive regulation of inflammatory response |
| Biological Process | GO:0032730 | positive regulation of interleukin-1 alpha production |
| Biological Process | GO:0032735 | positive regulation of interleukin-12 production |
| Biological Process | GO:0032755 | positive regulation of interleukin-6 production |
Reference
[1] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.