Search Results

Overview

Uniprot ID	Q14028
Protein Name	Cyclic nucleotide-gated channel beta-1
Gene Name	CNGB1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
1122	MTGKMGGKGAKGGKL

Function

Pore-forming subunit of the rod cyclic nucleotide-gated channel. Mediates rod photoresponses at dim light converting transient changes in intracellular cGMP levels into electrical signals. In the dark, cGMP levels are high and keep the channel open enabling a steady inward current carried by Na(+) and Ca(2+) ions that leads to membrane depolarization and neurotransmitter release from synaptic terminals. Upon photon absorption cGMP levels decline leading to channel closure and membrane hyperpolarization that ultimately slows neurotransmitter release and signals the presence of light, the end point of the phototransduction cascade (By similarity) (PubMed:34699778). Pore-forming subunit of the olfactory cyclic nucleotide-gated channel. Operates in the cilia of olfactory sensory neurons where chemical stimulation of the odorant is converted to an electrical signal. Mediates odorant-induced cAMP-dependent Ca(2+) influx triggering neuron depolarization. The rise of intracellular Ca(2+) levels potentiates the olfactory response by activating Ca(2+)-dependent Cl(-) channels, but it also serves as a negative feedback signal to desensitize the channel for rapid adaptation to odorants (By similarity). Conducts cGMP- and cAMP-gated ion currents, with permeability for monovalent and divalent cations. The selectivity for Ca(2+) over Na(+) increases with cGMP concentrations, whereas the selectivity among monovalent ions is independent of the cGMP levels (By similarity) (PubMed:34699778)

Protein Sequence

10 MLGWVQRVLP 20 QPPGTPRKTK 30 MQEEEEVEPE 40 PEMEAEVEPE 50 PNPEEAETES 60 ESMPPEESFK 70 EEEVAVADPS 80 PQETKEAALT 90 STISLRAQGA 100 EISEMNSPSR 110 RVLTWLMKGV 120 EKVIPQPVHS 130 ITEDPAQILG 140 HGSTGDTGCT 150 DEPNEALEAQ 160 DTRPGLRLLL 170 WLEQNLERVL 180 PQPPKSSEVW 190 RDEPAVATGA 200 ASDPAPPGRP 210 QEMGPKLQAR 220 ETPSLPTPIP 230 LQPKEEPKEA 240 PAPEPQPGSQ 250 AQTSSLPPTR 260 DPARLVAWVL 270 HRLEMALPQP 280 VLHGKIGEQE 290 PDSPGICDVQ 300 TISILPGGQV 310 EPDLVLEEVE 320 PPWEDAHQDV 330 STSPQGTEVV 340 PAYEEENKAV 350 EKMPRELSRI 360 EEEKEDEEEE 370 EEEEEEEEEE 380 EVTEVLLDSC 390 VVSQVGVGQS 400 EEDGTRPQST 410 SDQKLWEEVG 420 EEAKKEAEEK 430 AKEEAEEVAE 440 EEAEKEPQDW 450 AETKEEPEAE 460 AEAASSGVPA 470 TKQHPEVQVE 480 DTDADSCPLM 490 AEENPPSTVL 500 PPPSPAKSDT 510 LIVPSSASGT 520 HRKKLPSEDD 530 EAEELKALSP 540 AESPVVAWSD 550 PTTPKDTDGQ 560 DRAASTASTN 570 SAIINDRLQE 580 LVKLFKERTE 590 KVKEKLIDPD 600 VTSDEESPKP 610 SPAKKAPEPA 620 PDTKPAEAEP 630 VEEEHYCDML 640 CCKFKHRPWK 650 KYQFPQSIDP 660 LTNLMYVLWL 670 FFVVMAWNWN 680 CWLIPVRWAF 690 PYQTPDNIHH 700 WLLMDYLCDL 710 IYFLDITVFQ 720 TRLQFVRGGD 730 IITDKKDMRN 740 NYLKSRRFKM 750 DLLSLLPLDF 760 LYLKVGVNPL 770 LRLPRCLKYM 780 AFFEFNSRLE 790 SILSKAYVYR 800 VIRTTAYLLY 810 SLHLNSCLYY 820 WASAYQGLGS 830 THWVYDGVGN 840 SYIRCYYFAV 850 KTLITIGGLP 860 DPKTLFEIVF 870 QLLNYFTGVF 880 AFSVMIGQMR 890 DVVGAATAGQ 900 TYYRSCMDST 910 VKYMNFYKIP 920 KSVQNRVKTW 930 YEYTWHSQGM 940 LDESELMVQL 950 PDKMRLDLAI 960 DVNYNIVSKV 970 ALFQGCDRQM 980 IFDMLKRLRS 990 VVYLPNDYVC 1000 KKGEIGREMY 1010 IIQAGQVQVL 1020 GGPDGKSVLV 1030 TLKAGSVFGE 1040 ISLLAVGGGN 1050 RRTANVVAHG 1060 FTNLFILDKK 1070 DLNEILVHYP 1080 ESQKLLRKKA 1090 RRMLRSNNKP 1100 KEEKSVLILP 1110 PRAGTPKLFN 1120 AALAMTGKMG 1130 GKGAKGGKLA 1140 HLRARLKELA 1150 ALEAAAKQQE 1160 LVEQAKSSQD 1170 VKGEEGSAAP 1180 DQHTHPKEAA 1190 TDPPAPRTPP 1200 EPPGSPPSSP 1210 PPASLGRPEG 1220 EEEGPAEPEE 1230 HSVRICMSPG 1240 PEPGEQILSV 1250 KMPEEREEKA E

Gene Ontology

Classification	GO ID	Description
Molecular Function	GO:0030552	cAMP binding
Cellular Component	GO:0060170	ciliary membrane
Cellular Component	GO:0030660	Golgi-associated vesicle membrane
Cellular Component	GO:0017071	intracellular cyclic nucleotide activated cation channel complex
Cellular Component	GO:0098804	non-motile cilium membrane
Cellular Component	GO:0001750	photoreceptor outer segment
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0120200	rod photoreceptor outer segment
Cellular Component	GO:0043195	terminal bouton
Cellular Component	GO:1902495	transmembrane transporter complex
Molecular Function	GO:0005262	calcium channel activity
Molecular Function	GO:0030553	cGMP binding
Molecular Function	GO:0005222	intracellularly cAMP-activated cation channel activity
Molecular Function	GO:0005223	intracellularly cGMP-activated cation channel activity
Molecular Function	GO:0015276	ligand-gated monoatomic ion channel activity
Molecular Function	GO:0044877	protein-containing complex binding
Molecular Function	GO:0005272	sodium channel activity
Biological Process	GO:0006816	calcium ion transport
Biological Process	GO:0050911	detection of chemical stimulus involved in sensory perception of smell
Biological Process	GO:0050908	detection of light stimulus involved in visual perception
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway
Biological Process	GO:0051899	membrane depolarization
Biological Process	GO:0098655	monoatomic cation transmembrane transport
Biological Process	GO:0006812	monoatomic cation transport
Biological Process	GO:0021630	olfactory nerve maturation
Biological Process	GO:0006813	potassium ion transport
Biological Process	GO:0051480	regulation of cytosolic calcium ion concentration
Biological Process	GO:1990834	response to odorant
Biological Process	GO:0001895	retina homeostasis
Biological Process	GO:0007608	sensory perception of smell
Biological Process	GO:0006814	sodium ion transport
Biological Process	GO:0007601	visual perception

Reference

[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.