Search Results
Overview
| Uniprot ID | Q14103 |
|---|---|
| Protein Name | Heterogeneous nuclear ribonucleoprotein D0 |
| Gene Name | HNRNPD |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 110 | GLSWDTTKKDLKDYF |
| 129 | EVVDCTLKLDPITGR |
| 153 | KESESVDKVMDQKEH |
| 183 | KTKEPVKKIFVGGLS |
| 197 | SPDTPEEKIREYFGG |
| 218 | IELPMDNKTNKRRGF |
| 221 | PMDNKTNKRRGFCFI |
| 243 | VKKIMEKKYHNVGLS |
| 251 | YHNVGLSKCEIKVAM |
Function
Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. May play a role in the regulation of the rhythmic expression of circadian clock core genes. Directly binds to the 3'UTR of CRY1 mRNA and induces CRY1 rhythmic translation. May also be involved in the regulation of PER2 translation
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0014069 | postsynaptic density |
| Cellular Component | GO:1990904 | ribonucleoprotein complex |
| Molecular Function | GO:0003682 | chromatin binding |
| Molecular Function | GO:0042826 | histone deacetylase binding |
| Molecular Function | GO:0003680 | minor groove of adenine-thymine-rich DNA binding |
| Molecular Function | GO:0035925 | mRNA 3'-UTR AU-rich region binding |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0042162 | telomeric DNA binding |
| Biological Process | GO:0061158 | 3'-UTR-mediated mRNA destabilization |
| Biological Process | GO:0071230 | cellular response to amino acid stimulus |
| Biological Process | GO:0071392 | cellular response to estradiol stimulus |
| Biological Process | GO:0071732 | cellular response to nitric oxide |
| Biological Process | GO:1904586 | cellular response to putrescine |
| Biological Process | GO:0021549 | cerebellum development |
| Biological Process | GO:0097167 | circadian regulation of translation |
| Biological Process | GO:0070934 | CRD-mediated mRNA stabilization |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:1990828 | hepatocyte dedifferentiation |
| Biological Process | GO:0001889 | liver development |
| Biological Process | GO:1900152 | negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay |
| Biological Process | GO:2000767 | positive regulation of cytoplasmic translation |
| Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
| Biological Process | GO:1904355 | positive regulation of telomere capping |
| Biological Process | GO:0032212 | positive regulation of telomere maintenance via telomerase |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0045727 | positive regulation of translation |
| Biological Process | GO:0042752 | regulation of circadian rhythm |
| Biological Process | GO:0006355 | regulation of DNA-templated transcription |
| Biological Process | GO:0010468 | regulation of gene expression |
| Biological Process | GO:0051592 | response to calcium ion |
| Biological Process | GO:0051602 | response to electrical stimulus |
| Biological Process | GO:1901355 | response to rapamycin |
| Biological Process | GO:1904383 | response to sodium phosphate |
| Biological Process | GO:0006401 | RNA catabolic process |
| Biological Process | GO:0006396 | RNA processing |
Reference
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[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[3] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.
[4] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.
[5] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.
[6] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.
[7] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.
[8] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.
[9] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.
[10] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.
[11] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.