Search Results
Overview
| Uniprot ID | Q14108 |
|---|---|
| Protein Name | Lysosome membrane protein 2 |
| Gene Name | SCARB2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 129 | DQSVGDPKIDLIRTL |
| 39 | AVDQSIEKKIVLRNG |
| 391 | QINIYVKKLDDFVET |
Function
Acts as a lysosomal receptor for glucosylceramidase (GBA1) targeting
Protein Sequence
10
MGRCCFYTAG
20
TLSLLLLVTS
30
VTLLVARVFQ
40
KAVDQSIEKK
50
IVLRNGTEAF
60
DSWEKPPLPV
70
YTQFYFFNVT
80
NPEEILRGET
90
PRVEEVGPYT
100
YRELRNKANI
110
QFGDNGTTIS
120
AVSNKAYVFE
130
RDQSVGDPKI
140
DLIRTLNIPV
150
LTVIEWSQVH
160
FLREIIEAML
170
KAYQQKLFVT
180
HTVDELLWGY
190
KDEILSLIHV
200
FRPDISPYFG
210
LFYEKNGTND
220
GDYVFLTGED
230
SYLNFTKIVE
240
WNGKTSLDWW
250
ITDKCNMING
260
TDGDSFHPLI
270
TKDEVLYVFP
280
SDFCRSVYIT
290
FSDYESVQGL
300
PAFRYKVPAE
310
ILANTSDNAG
320
FCIPEGNCLG
330
SGVLNVSICK
340
NGAPIIMSFP
350
HFYQADERFV
360
SAIEGMHPNQ
370
EDHETFVDIN
380
PLTGIILKAA
390
KRFQINIYVK
400
KLDDFVETGD
410
IRTMVFPVMY
420
LNESVHIDKE
430
TASRLKSMIN
440
TTLIITNIPY
450
IIMALGVFFG
460
LVFTWLACKG
470
QGSMDEGTAD
ERAPLIRT
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030669 | clathrin-coated endocytic vesicle membrane |
| Cellular Component | GO:0030666 | endocytic vesicle membrane |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0010008 | endosome membrane |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0000139 | Golgi membrane |
| Cellular Component | GO:0031902 | late endosome membrane |
| Cellular Component | GO:0043202 | lysosomal lumen |
| Cellular Component | GO:0005765 | lysosomal membrane |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0038024 | cargo receptor activity |
| Molecular Function | GO:0015485 | cholesterol binding |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0031210 | phosphatidylcholine binding |
| Molecular Function | GO:0001786 | phosphatidylserine binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0051087 | protein-folding chaperone binding |
| Molecular Function | GO:0005044 | scavenger receptor activity |
| Molecular Function | GO:0004888 | transmembrane signaling receptor activity |
| Molecular Function | GO:0001618 | virus receptor activity |
| Biological Process | GO:0015917 | aminophospholipid transport |
| Biological Process | GO:0006914 | autophagy |
| Biological Process | GO:0010976 | positive regulation of neuron projection development |
| Biological Process | GO:0006622 | protein targeting to lysosome |
| Biological Process | GO:0006898 | receptor-mediated endocytosis |
| Biological Process | GO:0043470 | regulation of carbohydrate catabolic process |
| Biological Process | GO:1904978 | regulation of endosome organization |
| Biological Process | GO:2000752 | regulation of glucosylceramide catabolic process |
| Biological Process | GO:1905671 | regulation of lysosome organization |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.