Search Results

Overview

Uniprot IDQ14116
Protein NameInterleukin-18
Gene NameIL18
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
115 STLSCENKIISFKEM

Function

Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses (PubMed:10653850). Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators (PubMed:14528293, PubMed:25500532, PubMed:37993714). Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells (PubMed:10653850). Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore (PubMed:33883744)

Protein Sequence

10 MAAEPVEDNC 20 INFVAMKFID 30 NTLYFIAEDD 40 ENLESDYFGK 50 LESKLSVIRN 60 LNDQVLFIDQ 70 GNRPLFEDMT 80 DSDCRDNAPR 90 TIFIISMYKD 100 SQPRGMAVTI 110 SVKCEKISTL 120 SCENKIISFK 130 EMNPPDNIKD 140 TKSDIIFFQR 150 SVPGHDNKMQ 160 FESSSYEGYF 170 LACEKERDLF 180 KLILKKEDEL 190 GDRSIMFTVQ NED

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Biological Process GO:0006955 immune response
Biological Process GO:0006954 inflammatory response
Biological Process GO:0035655 interleukin-18-mediated signaling pathway
Biological Process GO:0002826 negative regulation of T-helper 1 type immune response
Biological Process GO:0042104 positive regulation of activated T cell proliferation
Biological Process GO:0032722 positive regulation of chemokine production
Biological Process GO:0120162 positive regulation of cold-induced thermogenesis
Biological Process GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production
Biological Process GO:0050729 positive regulation of inflammatory response
Biological Process GO:0032736 positive regulation of interleukin-13 production
Biological Process GO:0032740 positive regulation of interleukin-17 production
Biological Process GO:0010744 positive regulation of macrophage derived foam cell differentiation
Biological Process GO:0032819 positive regulation of natural killer cell proliferation
Biological Process GO:0150078 positive regulation of neuroinflammatory response
Biological Process GO:0051142 positive regulation of NK T cell proliferation
Biological Process GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction
Biological Process GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Biological Process GO:0048661 positive regulation of smooth muscle cell proliferation
Biological Process GO:2000556 positive regulation of T-helper 1 cell cytokine production
Biological Process GO:0045630 positive regulation of T-helper 2 cell differentiation
Biological Process GO:0034105 positive regulation of tissue remodeling
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0032729 positive regulation of type II interferon production
Biological Process GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
Biological Process GO:0030155 regulation of cell adhesion
Biological Process GO:0030431 sleep
Biological Process GO:0045063 T-helper 1 cell differentiation
Biological Process GO:0042088 T-helper 1 type immune response
Biological Process GO:0070328 triglyceride homeostasis
Biological Process GO:0042092 type 2 immune response
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0005615 extracellular space
Molecular Function GO:0005125 cytokine activity
Molecular Function GO:0045515 interleukin-18 receptor binding
Biological Process GO:0001525 angiogenesis
Biological Process GO:0007267 cell-cell signaling
Biological Process GO:0071222 cellular response to lipopolysaccharide
Biological Process GO:0042632 cholesterol homeostasis
Biological Process GO:0019221 cytokine-mediated signaling pathway
Biological Process GO:0050830 defense response to Gram-positive bacterium
Biological Process GO:0061436 establishment of skin barrier

Reference

[1] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.