Overview
| Uniprot ID | Q14123 |
|---|
| Protein Name | Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C |
|---|
| Gene Name | PDE1C |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 573 |
KKTSGETKNQVNGTR |
Function
Calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:29860631, PubMed:8557689). Has a high affinity for both cAMP and cGMP (PubMed:8557689). Modulates the amplitude and duration of the cAMP signal in sensory cilia in response to odorant stimulation, hence contributing to the generation of action potentials. Regulates smooth muscle cell proliferation. Regulates the stability of growth factor receptors, including PDGFRB (Probable). In kidney juxtaglomerular granular cells, inhibits renin release by decreasing cAMP levels (By similarity)
Protein Sequence
10
MESPTKEIEE
20
FESNSLKYLQ
30
PEQIEKIWLR
40
LRGLRKYKKT
50
SQRLRSLVKQ
60
LERGEASVVD
70
LKKNLEYAAT
80
VLESVYIDET
90
RRLLDTEDEL
100
SDIQSDAVPS
110
EVRDWLASTF
120
TRQMGMMLRR
130
SDEKPRFKSI
140
VHAVQAGIFV
150
ERMYRRTSNM
160
VGLSYPPAVI
170
EALKDVDKWS
180
FDVFSLNEAS
190
GDHALKFIFY
200
ELLTRYDLIS
210
RFKIPISALV
220
SFVEALEVGY
230
SKHKNPYHNL
240
MHAADVTQTV
250
HYLLYKTGVA
260
NWLTELEIFA
270
IIFSAAIHDY
280
EHTGTTNNFH
290
IQTRSDPAIL
300
YNDRSVLENH
310
HLSAAYRLLQ
320
DDEEMNILIN
330
LSKDDWREFR
340
TLVIEMVMAT
350
DMSCHFQQIK
360
AMKTALQQPE
370
AIEKPKALSL
380
MLHTADISHP
390
AKAWDLHHRW
400
TMSLLEEFFR
410
QGDREAELGL
420
PFSPLCDRKS
430
TMVAQSQVGF
440
IDFIVEPTFT
450
VLTDMTEKIV
460
SPLIDETSQT
470
GGTGQRRSSL
480
NSISSSDAKR
490
SGVKTSGSEG
500
SAPINNSVIS
510
VDYKSFKATW
520
TEVVHINRER
530
WRAKVPKEEK
540
AKKEAEEKAR
550
LAAEEQQKEM
560
EAKSQAEEGA
570
SGKAEKKTSG
580
ETKNQVNGTR
590
ANKSDNPRGK
600
NSKAEKSSGE
610
QQQNGDFKDG
620
KNKTDKKDHS
630
NIGNDSKKTD
640
GTKQRSHGSP
650
APSTSSTCRL
660
TLPVIKPPLR
670
HFKRPAYASS
680
SYAPSVSKKT
690
DEHPARYKML
700
DQRIKMKKIQ
NISHNWNRK
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005764 |
lysosome |
| Cellular Component |
GO:0043025 |
neuronal cell body |
| Molecular Function |
GO:0004115 |
3',5'-cyclic-AMP phosphodiesterase activity |
| Molecular Function |
GO:0047555 |
3',5'-cyclic-GMP phosphodiesterase activity |
| Molecular Function |
GO:0005516 |
calmodulin binding |
| Molecular Function |
GO:0048101 |
calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity |
| Molecular Function |
GO:0004117 |
calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity |
| Molecular Function |
GO:0046872 |
metal ion binding |
| Biological Process |
GO:0141162 |
negative regulation of cAMP/PKA signal transduction |
| Biological Process |
GO:0007165 |
signal transduction |
Reference
[1] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.