Search Results

Overview

Uniprot ID	Q14126
Protein Name	Desmoglein-2
Gene Name	DSG2
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
1109	TSSTRVTKHSTVQHS

Function

A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:17559062, PubMed:38395410). Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Required for proliferation and viability of embryonic stem cells in the blastocyst, thereby crucial for progression of post-implantation embryonic development (By similarity). Maintains pluripotency by regulating epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via interacting with and sequestering CTNNB1 to sites of cell-cell contact, thereby reducing translocation of CTNNB1 to the nucleus and subsequent transcription of CTNNB1/TCF-target genes (PubMed:29910125). Promotes pluripotency and the multi-lineage differentiation potential of hematopoietic stem cells (PubMed:27338829). Plays a role in endothelial cell sprouting and elongation via mediating the junctional-association of cortical actin fibers and CDH5 (PubMed:27338829). Promotes cardiomyocyte cell homeostasis and desmosome junction formation at intercalated disks, as a result plays a role in the maintenance of cardiac conduction and heart chamber integrity (By similarity). Positively regulates pancreatic islet development and maintenance of endothelial cell barrier integrity in the pancreas, therefore involved in the controlled release of insulin from islet cells into the circulation in response to glucose (By similarity). Plays a role in limiting inflammatory infiltration and the apoptotic response to injury in kidney tubular epithelial cells, potentially via its role in maintaining cell-cell adhesion and the epithelial barrier (PubMed:38395410). Acts as a positive modulator of CSK and EGFR activation via sequestering them away from lipid rafts, this is independent of its role in desmosome cell junctions (PubMed:26918609). Also disrupts the localization of CAV1 to lipid rafts resulting in its distribution throughout the cytoplasm (PubMed:26918609)

Protein Sequence

10 MARSPGRAYA 20 LLLLLICFNV 30 GSGLHLQVLS 40 TRNENKLLPK 50 HPHLVRQKRA 60 WITAPVALRE 70 GEDLSKKNPI 80 AKIHSDLAEE 90 RGLKITYKYT 100 GKGITEPPFG 110 IFVFNKDTGE 120 LNVTSILDRE 130 ETPFFLLTGY 140 ALDARGNNVE 150 KPLELRIKVL 160 DINDNEPVFT 170 QDVFVGSVEE 180 LSAAHTLVMK 190 INATDADEPN 200 TLNSKISYRI 210 VSLEPAYPPV 220 FYLNKDTGEI 230 YTTSVTLDRE 240 EHSSYTLTVE 250 ARDGNGEVTD 260 KPVKQAQVQI 270 RILDVNDNIP 280 VVENKVLEGM 290 VEENQVNVEV 300 TRIKVFDADE 310 IGSDNWLANF 320 TFASGNEGGY 330 FHIETDAQTN 340 EGIVTLIKEV 350 DYEEMKNLDF 360 SVIVANKAAF 370 HKSIRSKYKP 380 TPIPIKVKVK 390 NVKEGIHFKS 400 SVISIYVSES 410 MDRSSKGQII 420 GNFQAFDEDT 430 GLPAHARYVK 440 LEDRDNWISV 450 DSVTSEIKLA 460 KLPDFESRYV 470 QNGTYTVKIV 480 AISEDYPRKT 490 ITGTVLINVE 500 DINDNCPTLI 510 EPVQTICHDA 520 EYVNVTAEDL 530 DGHPNSGPFS 540 FSVIDKPPGM 550 AEKWKIARQE 560 STSVLLQQSE 570 KKLGRSEIQF 580 LISDNQGFSC 590 PEKQVLTLTV 600 CECLHGSGCR 610 EAQHDSYVGL 620 GPAAIALMIL 630 AFLLLLLVPL 640 LLLMCHCGKG 650 AKGFTPIPGT 660 IEMLHPWNNE 670 GAPPEDKVVP 680 SFLPVDQGGS 690 LVGRNGVGGM 700 AKEATMKGSS 710 SASIVKGQHE 720 MSEMDGRWEE 730 HRSLLSGRAT 740 QFTGATGAIM 750 TTETTKTARA 760 TGASRDMAGA 770 QAAAVALNEE 780 FLRNYFTDKA 790 ASYTEEDENH 800 TAKDCLLVYS 810 QEETESLNAS 820 IGCCSFIEGE 830 LDDRFLDDLG 840 LKFKTLAEVC 850 LGQKIDINKE 860 IEQRQKPATE 870 TSMNTASHSL 880 CEQTMVNSEN 890 TYSSGSSFPV 900 PKSLQEANAE 910 KVTQEIVTER 920 SVSSRQAQKV 930 ATPLPDPMAS 940 RNVIATETSY 950 VTGSTMPPTT 960 VILGPSQPQS 970 LIVTERVYAP 980 ASTLVDQPYA 990 NEGTVVVTER 1000 VIQPHGGGSN 1010 PLEGTQHLQD 1020 VPYVMVRERE 1030 SFLAPSSGVQ 1040 PTLAMPNIAV 1050 GQNVTVTERV 1060 LAPASTLQSS 1070 YQIPTENSMT 1080 ARNTTVSGAG 1090 VPGPLPDFGL 1100 EESGHSNSTI 1110 TTSSTRVTKH STVQHSYS

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0030054	cell junction
Cellular Component	GO:0009986	cell surface
Cellular Component	GO:0005911	cell-cell junction
Cellular Component	GO:0001533	cornified envelope
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0030057	desmosome
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0014704	intercalated disc
Cellular Component	GO:0005886	plasma membrane
Molecular Function	GO:0005509	calcium ion binding
Molecular Function	GO:0050839	cell adhesion molecule binding
Molecular Function	GO:0086083	cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication
Biological Process	GO:0086073	bundle of His cell-Purkinje myocyte adhesion involved in cell communication
Biological Process	GO:0007155	cell adhesion
Biological Process	GO:0098609	cell-cell adhesion
Biological Process	GO:0002934	desmosome organization
Biological Process	GO:0007156	homophilic cell-cell adhesion
Biological Process	GO:0060231	mesenchymal to epithelial transition
Biological Process	GO:0043066	negative regulation of apoptotic process
Biological Process	GO:0045602	negative regulation of endothelial cell differentiation
Biological Process	GO:0010719	negative regulation of epithelial to mesenchymal transition
Biological Process	GO:0106015	negative regulation of inflammatory response to wounding
Biological Process	GO:0045785	positive regulation of cell adhesion
Biological Process	GO:0150107	positive regulation of protein localization to cell-cell junction
Biological Process	GO:1903672	positive regulation of sprouting angiogenesis
Biological Process	GO:1902459	positive regulation of stem cell population maintenance
Biological Process	GO:0003165	Purkinje myocyte development
Biological Process	GO:0086091	regulation of heart rate by cardiac conduction
Biological Process	GO:0098911	regulation of ventricular cardiac muscle cell action potential
Biological Process	GO:0072089	stem cell proliferation

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.