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Overview

Uniprot ID	Q14134
Protein Name	Tripartite motif-containing protein 29
Gene Name	TRIM29
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
115	GLQLGAAKKPPVTFA
129	AEKGELRKSIFSESR
165	TGLFSRSKSGSEEVL
478	YSMYLTPKGGVRTSY
495	SSPGRFTKETTQKNF
500	FTKETTQKNFNNLYG
554	LMRSQSPKAQPQTWK

Function

Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of pro-inflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation

Protein Sequence

10 MEAADASRSN 20 GSSPEARDAR 30 SPSGPSGSLE 40 NGTKADGKDA 50 KTTNGHGGEA 60 AEGKSLGSAL 70 KPGEGRSALF 80 AGNEWRRPII 90 QFVESGDDKN 100 SNYFSMDSME 110 GKRSPYAGLQ 120 LGAAKKPPVT 130 FAEKGELRKS 140 IFSESRKPTV 150 SIMEPGETRR 160 NSYPRADTGL 170 FSRSKSGSEE 180 VLCDSCIGNK 190 QKAVKSCLVC 200 QASFCELHLK 210 PHLEGAAFRD 220 HQLLEPIRDF 230 EARKCPVHGK 240 TMELFCQTDQ 250 TCICYLCMFQ 260 EHKNHSTVTV 270 EEAKAEKETE 280 LSLQKEQLQL 290 KIIEIEDEAE 300 KWQKEKDRIK 310 SFTTNEKAIL 320 EQNFRDLVRD 330 LEKQKEEVRA 340 ALEQREQDAV 350 DQVKVIMDAL 360 DERAKVLHED 370 KQTREQLHSI 380 SDSVLFLQEF 390 GALMSNYSLP 400 PPLPTYHVLL 410 EGEGLGQSLG 420 NFKDDLLNVC 430 MRHVEKMCKA 440 DLSRNFIERN 450 HMENGGDHRY 460 VNNYTNSFGG 470 EWSAPDTMKR 480 YSMYLTPKGG 490 VRTSYQPSSP 500 GRFTKETTQK 510 NFNNLYGTKG 520 NYTSRVWEYS 530 SSIQNSDNDL 540 PVVQGSSSFS 550 LKGYPSLMRS 560 QSPKAQPQTW 570 KSGKQTMLSH 580 YRPFYVNKGN GIGSNEAP

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005912	adherens junction
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005764	lysosome
Molecular Function	GO:0098641	cadherin binding involved in cell-cell adhesion
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:0002039	p53 binding
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0045087	innate immune response

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.