Search Results
Overview
| Uniprot ID | Q14137 |
|---|---|
| Protein Name | Ribosome biogenesis protein BOP1 |
| Gene Name | BOP1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 19 | APSVRPEKRRSEPEL |
| 253 | FIPSLVEKEKVSRMV |
| 96 | EGHSGIKKTTEEQVQ |
Function
Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome
Protein Sequence
10
MAGSRGAGRT
20
AAPSVRPEKR
30
RSEPELEPEP
40
EPEPPLLCTS
50
PLSHSTGSDS
60
GVSDSEESVF
70
SGLEDSGSDS
80
SEDDDEGDEE
90
GEDGALDDEG
100
HSGIKKTTEE
110
QVQASTPCPR
120
TEMASARIGD
130
EYAEDSSDEE
140
DIRNTVGNVP
150
LEWYDDFPHV
160
GYDLDGRRIY
170
KPLRTRDELD
180
QFLDKMDDPD
190
YWRTVQDPMT
200
GRDLRLTDEQ
210
VALVRRLQSG
220
QFGDVGFNPY
230
EPAVDFFSGD
240
VMIHPVTNRP
250
ADKRSFIPSL
260
VEKEKVSRMV
270
HAIKMGWIQP
280
RRPRDPTPSF
290
YDLWAQEDPN
300
AVLGRHKMHV
310
PAPKLALPGH
320
AESYNPPPEY
330
LLSEEERLAW
340
EQQEPGERKL
350
SFLPRKFPSL
360
RAVPAYGRFI
370
QERFERCLDL
380
YLCPRQRKMR
390
VNVDPEDLIP
400
KLPRPRDLQP
410
FPTCQALVYR
420
GHSDLVRCLS
430
VSPGGQWLVS
440
GSDDGSLRLW
450
EVATARCVRT
460
VPVGGVVKSV
470
AWNPSPAVCL
480
VAAAVEDSVL
490
LLNPALGDRL
500
VAGSTDQLLS
510
AFVPPEEPPL
520
QPARWLEASE
530
EERQVGLRLR
540
ICHGKPVTQV
550
TWHGRGDYLA
560
VVLATQGHTQ
570
VLIHQLSRRR
580
SQSPFRRSHG
590
QVQRVAFHPA
600
RPFLLVASQR
610
SVRLYHLLRQ
620
ELTKKLMPNC
630
KWVSSLAVHP
640
AGDNVICGSY
650
DSKLVWFDLD
660
LSTKPYRMLR
670
HHKKALRAVA
680
FHPRYPLFAS
690
GSDDGSVIVC
700
HGMVYNDLLQ
710
NPLLVPVKVL
720
KGHVLTRDLG
730
VLDVIFHPTQ
740
PWVFSSGADG
TVRLFT
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005694 | chromosome |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0070545 | PeBoW complex |
| Cellular Component | GO:0030687 | preribosome, large subunit precursor |
| Cellular Component | GO:1990904 | ribonucleoprotein complex |
| Molecular Function | GO:0043021 | ribonucleoprotein complex binding |
| Molecular Function | GO:0003723 | RNA binding |
| Biological Process | GO:0008283 | cell population proliferation |
| Biological Process | GO:0000448 | cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
| Biological Process | GO:0000463 | maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
| Biological Process | GO:0051726 | regulation of cell cycle |
| Biological Process | GO:1901796 | regulation of signal transduction by p53 class mediator |
| Biological Process | GO:0000027 | ribosomal large subunit assembly |
| Biological Process | GO:0042273 | ribosomal large subunit biogenesis |
| Biological Process | GO:0042254 | ribosome biogenesis |
| Biological Process | GO:0006364 | rRNA processing |
Reference
[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.
[2] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.
[3] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.