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Overview

Uniprot IDQ14141
Protein NameSeptin-6
Gene NameSEPTIN6
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
171 SLDLVTMKKLDSKVN
379 KKLHQDEKKKLEDKK
400 VNAFKQRKTAAELLQ
420 AGGSQTLKRDKEKKN

Function

Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. May play a role in HCV RNA replication. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830)

Protein Sequence

10 MAATDIARQV 20 GEGCRTVPLA 30 GHVGFDSLPD 40 QLVNKSVSQG 50 FCFNILCVGE 60 TGLGKSTLMD 70 TLFNTKFEGE 80 PATHTQPGVQ 90 LQSNTYDLQE 100 SNVRLKLTIV 110 STVGFGDQIN 120 KEDSYKPIVE 130 FIDAQFEAYL 140 QEELKIRRVL 150 HTYHDSRIHV 160 CLYFIAPTGH 170 SLKSLDLVTM 180 KKLDSKVNII 190 PIIAKADAIS 200 KSELTKFKIK 210 ITSELVSNGV 220 QIYQFPTDDE 230 SVAEINGTMN 240 AHLPFAVIGS 250 TEELKIGNKM 260 MRARQYPWGT 270 VQVENEAHCD 280 FVKLREMLIR 290 VNMEDLREQT 300 HTRHYELYRR 310 CKLEEMGFKD 320 TDPDSKPFSL 330 QETYEAKRNE 340 FLGELQKKEE 350 EMRQMFVQRV 360 KEKEAELKEA 370 EKELHEKFDR 380 LKKLHQDEKK 390 KLEDKKKSLD 400 DEVNAFKQRK 410 TAAELLQSQG 420 SQAGGSQTLK 430 RDKEKKNNPW LCTE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0043679 axon terminus
Cellular Component GO:0032153 cell division site
Cellular Component GO:0032154 cleavage furrow
Cellular Component GO:0000776 kinetochore
Cellular Component GO:0015630 microtubule cytoskeleton
Cellular Component GO:0030496 midbody
Cellular Component GO:0032173 septin collar
Cellular Component GO:0031105 septin complex
Cellular Component GO:0005940 septin ring
Cellular Component GO:0097227 sperm annulus
Cellular Component GO:0005819 spindle
Cellular Component GO:0008021 synaptic vesicle
Molecular Function GO:0005525 GTP binding
Molecular Function GO:0003924 GTPase activity
Molecular Function GO:0060090 molecular adaptor activity
Biological Process GO:0030154 cell differentiation
Biological Process GO:0007010 cytoskeleton organization
Biological Process GO:0061640 cytoskeleton-dependent cytokinesis
Biological Process GO:0008104 intracellular protein localization
Biological Process GO:0000281 mitotic cytokinesis
Biological Process GO:0007283 spermatogenesis

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.