Overview
| Uniprot ID | Q14149 |
|---|
| Protein Name | MORC family CW-type zinc finger protein 3 |
|---|
| Gene Name | MORC3 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 467 |
PTYEKTYKKTNKEKF |
| 555 |
RSSILNAKNRRLSSQ |
Function
Nuclear matrix protein which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism and plays a role in innate immunity by restricting different viruses through modulation of the IFN response (PubMed:27440897, PubMed:34759314). Mechanistically, possesses a primary antiviral function through a MORC3-regulated element that activates IFNB1, and this function is guarded by a secondary IFN-repressing function (PubMed:34759314). Sumoylated MORC3-NBs associates with PML-NBs and recruits TP53 and SP100, thus regulating TP53 activity (PubMed:17332504, PubMed:20501696). Binds RNA in vitro (PubMed:11927593). Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3 (PubMed:26933034). The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0 (PubMed:26933034)
Protein Sequence
10
MAAQPPRGIR
20
LSALCPKFLH
30
TNSTSHTWPF
40
SAVAELIDNA
50
YDPDVNAKQI
60
WIDKTVINDH
70
ICLTFTDNGN
80
GMTSDKLHKM
90
LSFGFSDKVT
100
MNGHVPVGLY
110
GNGFKSGSMR
120
LGKDAIVFTK
130
NGESMSVGLL
140
SQTYLEVIKA
150
EHVVVPIVAF
160
NKHRQMINLA
170
ESKASLAAIL
180
EHSLFSTEQK
190
LLAELDAIIG
200
KKGTRIIIWN
210
LRSYKNATEF
220
DFEKDKYDIR
230
IPEDLDEITG
240
KKGYKKQERM
250
DQIAPESDYS
260
LRAYCSILYL
270
KPRMQIILRG
280
QKVKTQLVSK
290
SLAYIERDVY
300
RPKFLSKTVR
310
ITFGFNCRNK
320
DHYGIMMYHR
330
NRLIKAYEKV
340
GCQLRANNMG
350
VGVVGIIECN
360
FLKPTHNKQD
370
FDYTNEYRLT
380
ITALGEKLND
390
YWNEMKVKKN
400
TEYPLNLPVE
410
DIQKRPDQTW
420
VQCDACLKWR
430
KLPDGMDQLP
440
EKWYCSNNPD
450
PQFRNCEVPE
460
EPEDEDLVHP
470
TYEKTYKKTN
480
KEKFRIRQPE
490
MIPRINAELL
500
FRPTALSTPS
510
FSSPKESVPR
520
RHLSEGTNSY
530
ATRLLNNHQV
540
PPQSEPESNS
550
LKRRLSTRSS
560
ILNAKNRRLS
570
SQFENSVYKG
580
DDDDEDVIIL
590
EENSTPKPAV
600
DHDIDMKSEQ
610
SHVEQGGVQV
620
EFVGDSEPCG
630
QTGSTSTSSS
640
RCDQGNTAAT
650
QTEVPSLVVK
660
KEETVEDEID
670
VRNDAVILPS
680
CVEAEAKIHE
690
TQETTDKSAD
700
DAGCQLQELR
710
NQLLLVTEEK
720
ENYKRQCHMF
730
TDQIKVLQQR
740
ILEMNDKYVK
750
KETCHQSTET
760
DAVFLLESIN
770
GKSESPDHMV
780
SQYQQALEEI
790
ERLKKQCSAL
800
QHVKAECSQC
810
SNNESKSEMD
820
EMAVQLDDVF
830
RQLDKCSIER
840
DQYKSEVELL
850
EMEKSQIRSQ
860
CEELKTEVEQ
870
LKSTNQQTAT
880
DVSTSSNIEE
890
SVNHMDGESL
900
KLRSLRVNVG
910
QLLAMIVPDL
920
DLQQVNYDVD
930
VVDEILGQVV
EQMSEISST
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0000785 |
chromatin |
| Cellular Component |
GO:0016363 |
nuclear matrix |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0016605 |
PML body |
| Molecular Function |
GO:0016887 |
ATP hydrolysis activity |
| Molecular Function |
GO:0003677 |
DNA binding |
| Molecular Function |
GO:0140002 |
histone H3K4me3 reader activity |
| Molecular Function |
GO:0030674 |
protein-macromolecule adaptor activity |
| Molecular Function |
GO:0003723 |
RNA binding |
| Molecular Function |
GO:0008270 |
zinc ion binding |
| Biological Process |
GO:0140374 |
antiviral innate immune response |
| Biological Process |
GO:0051457 |
maintenance of protein location in nucleus |
| Biological Process |
GO:0048147 |
negative regulation of fibroblast proliferation |
| Biological Process |
GO:0032688 |
negative regulation of interferon-beta production |
| Biological Process |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
| Biological Process |
GO:0018105 |
peptidyl-serine phosphorylation |
| Biological Process |
GO:2000774 |
positive regulation of cellular senescence |
| Biological Process |
GO:0006468 |
protein phosphorylation |
| Biological Process |
GO:0050821 |
protein stabilization |
Reference
PMID: N/A