Search Results

Overview

Uniprot IDQ14151
Protein NameScaffold attachment factor B2
Gene NameSAFB2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
293 DSLLAVVKREPAEQP
355 DSKEDGRKFDFDACN
380 TSEGADQKMSSFKEE
395 KDIKPIIKDEKGRVG
424 TTRATDLKNLFSKYG
432 NLFSKYGKVVGAKVV
437 YGKVVGAKVVTNARS
504 ECEVKKEKLSSVDRH
520 SVEIKIEKTVIKKEE
53 NLDTGGNKSVLMERL
576 ERTVVMDKSKGEPVI
578 TVVMDKSKGEPVISV
616 RDILSFDKIKEQRER
618 ILSFDKIKEQRERER
62 VLMERLKKAVKEEGQ
746 DAYWPEGKRVAMEDR

Function

Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation

Protein Sequence

10 MAETLPGSGD 20 SGPGTASLGP 30 GVAETGTRRL 40 SELRVIDLRA 50 ELKKRNLDTG 60 GNKSVLMERL 70 KKAVKEEGQD 80 PDEIGIELEA 90 TSKKSAKRCV 100 KGLKMEEEGT 110 EDNGLEDDSR 120 DGQEDMEASL 130 ENLQNMGMMD 140 MSVLDETEVA 150 NSSAPDFGED 160 GTDGLLDSFC 170 DSKEYVAAQL 180 RQLPAQPPEH 190 AVDGEGFKNT 200 LETSSLNFKV 210 TPDIEESLLE 220 PENEKILDIL 230 GETCKSEPVK 240 EESSELEQPF 250 AQDTSSVGPD 260 RKLAEEEDLF 270 DSAHPEEGDL 280 DLASESTAHA 290 QSSKADSLLA 300 VVKREPAEQP 310 GDGERTDCEP 320 VGLEPAVEQS 330 SAASELAEAS 340 SEELAEAPTE 350 APSPEARDSK 360 EDGRKFDFDA 370 CNEVPPAPKE 380 SSTSEGADQK 390 MSSFKEEKDI 400 KPIIKDEKGR 410 VGSGSGRNLW 420 VSGLSSTTRA 430 TDLKNLFSKY 440 GKVVGAKVVT 450 NARSPGARCY 460 GFVTMSTSDE 470 ATKCISHLHR 480 TELHGRMISV 490 EKAKNEPAGK 500 KLSDRKECEV 510 KKEKLSSVDR 520 HHSVEIKIEK 530 TVIKKEEKIE 540 KKEEKKPEDI 550 KKEEKDQDEL 560 KPGPTNRSRV 570 TKSGSRGMER 580 TVVMDKSKGE 590 PVISVKTTSR 600 SKERSSKSQD 610 RKSESKEKRD 620 ILSFDKIKEQ 630 RERERQRQRE 640 REIRETERRR 650 EREQREREQR 660 LEAFHERKEK 670 ARLQRERLQL 680 ECQRQRLERE 690 RMERERLERE 700 RMRVERERRK 710 EQERIHRERE 720 ELRRQQEQLR 730 YEQERRPGRR 740 PYDLDRRDDA 750 YWPEGKRVAM 760 EDRYRADFPR 770 PDHRFHDFDH 780 RDRGQYQDHA 790 IDRREGSRPM 800 MGDHRDGQHY 810 GDDRHGHGGP 820 PERHGRDSRD 830 GWGGYGSDKR 840 LSEGRGLPPP 850 PRGGRDWGEH 860 NQRLEEHQAR 870 AWQGAMDAGA 880 ASREHARWQG 890 GERGLSGPSG 900 PGHMASRGGV 910 AGRGGFAQGG 920 HSQGHVVPGG 930 GLEGGGVASQ 940 DRGSRVPHPH 950 PHPPPYPHFT RRY

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0016604 nuclear body
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0003723 RNA binding
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0060765 regulation of androgen receptor signaling pathway

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.