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Overview

Uniprot IDQ14155
Protein NameRho guanine nucleotide exchange factor 7
Gene NameARHGEF7
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
260 GTLKSPPKGFDTTAI
725 EAYCTSAKTRQTLNS

Function

Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons

Protein Sequence

10 MNSAEQTVTW 20 LITLGVLESP 30 KKTISDPEGF 40 LQASLKDGVV 50 LCRLLERLLP 60 GTIEKVYPEP 70 RSESECLSNI 80 REFLRGCGAS 90 LRLELLFPPS 100 QPPQHLVTTI 110 LLSASTFDAN 120 DLYQGQNFNK 130 VLSSLVTLNK 140 VTADIGLGSD 150 SVCARPSSHR 160 IKSFDSLGSQ 170 SLHTRTSKLF 180 QGQYRSLDMT 190 DNSNNQLVVR 200 AKFNFQQTNE 210 DELSFSKGDV 220 IHVTRVEEGG 230 WWEGTLNGRT 240 GWFPSNYVRE 250 VKASEKPVSP 260 KSGTLKSPPK 270 GFDTTAINKS 280 YYNVVLQNIL 290 ETENEYSKEL 300 QTVLSTYLRP 310 LQTSEKLSSA 320 NISYLMGNLE 330 EICSFQQMLV 340 QSLEECTKLP 350 EAQQRVGGCF 360 LNLMPQMKTL 370 YLTYCANHPS 380 AVNVLTEHSE 390 ELGEFMETKG 400 ASSPGILVLT 410 TGLSKPFMRL 420 DKYPTLLKEL 430 ERHMEDYHTD 440 RQDIQKSMAA 450 FKNLSAQCQE 460 VRKRKELELQ 470 ILTEAIRNWE 480 GDDIKTLGNV 490 TYMSQVLIQC 500 AGSEEKNERY 510 LLLFPNVLLM 520 LSASPRMSGF 530 IYQGKLPTTG 540 MTITKLEDSE 550 NHRNAFEISG 560 SMIERILVSC 570 NNQQDLQEWV 580 EHLQKQTKVT 590 SVGNPTIKPH 600 SVPSHTLPSH 610 PVTPSSKHAD 620 SKPAPLTPAY 630 HTLPHPSHHG 640 TPHTTINWGP 650 LEPPKTPKPW 660 SLSCLRPAPP 670 LRPSAALCYK 680 EDLSKSPKTM 690 KKLLPKRKPE 700 RKPSDEEFAS 710 RKSTAALEED 720 AQILKVIEAY 730 CTSAKTRQTL 740 NSTWQGTDLM 750 HNHVLADDDQ 760 PSLDSLGRRS 770 SLSRLEPSDL 780 SEDSDYDSIW 790 TAHSYRMGST 800 SRKSCCSYIS HQN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005938 cell cortex
Cellular Component GO:0097431 mitotic spindle pole
Cellular Component GO:0043005 neuron projection
Cellular Component GO:0043025 neuronal cell body
Cellular Component GO:0098794 postsynapse
Cellular Component GO:0032991 protein-containing complex
Cellular Component GO:0001726 ruffle
Molecular Function GO:0043015 gamma-tubulin binding
Molecular Function GO:0005085 guanyl-nucleotide exchange factor activity
Molecular Function GO:0019901 protein kinase binding
Biological Process GO:0048013 ephrin receptor signaling pathway
Biological Process GO:0048041 focal adhesion assembly
Biological Process GO:0007030 Golgi organization
Biological Process GO:0030032 lamellipodium assembly
Biological Process GO:1905833 negative regulation of microtubule nucleation
Biological Process GO:0007399 nervous system development
Biological Process GO:0043065 positive regulation of apoptotic process
Biological Process GO:0010763 positive regulation of fibroblast migration
Biological Process GO:2000394 positive regulation of lamellipodium morphogenesis
Biological Process GO:1900026 positive regulation of substrate adhesion-dependent cell spreading
Biological Process GO:0007266 Rho protein signal transduction
Biological Process GO:0007165 signal transduction
Cellular Component GO:0005813 centrosome
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0030027 lamellipodium

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.