Search Results

Overview

Uniprot IDQ14157
Protein NameUbiquitin-associated protein 2-like
Gene NameUBAP2L
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
420 AVHSPFTKRQAFTPS
491 KLKQQKKKASLTSKI
864 PYSGDLTKFGRGDAS

Function

Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs) (By similarity). Is a regulator of stress granule assembly, required for their efficient formation (PubMed:29395067, PubMed:35977029). Required for proper brain development and neocortex lamination (By similarity)

Protein Sequence

10 MMTSVGTNRA 20 RGNWEQPQNQ 30 NQTQHKQRPQ 40 ATAEQIRLAQ 50 MISDHNDADF 60 EEKVKQLIDI 70 TGKNQDECVI 80 ALHDCNGDVN 90 RAINVLLEGN 100 PDTHSWEMVG 110 KKKGVSGQKD 120 GGQTESNEEG 130 KENRDRDRDY 140 SRRRGGPPRR 150 GRGASRGREF 160 RGQENGLDGT 170 KSGGPSGRGT 180 ERGRRGRGRG 190 RGGSGRRGGR 200 FSAQGMGTFN 210 PADYAEPANT 220 DDNYGNSSGN 230 TWNNTGHFEP 240 DDGTSAWRTA 250 TEEWGTEDWN 260 EDLSETKIFT 270 ASNVSSVPLP 280 AENVTITAGQ 290 RIDLAVLLGK 300 TPSTMENDSS 310 NLDPSQAPSL 320 AQPLVFSNSK 330 QTAISQPASG 340 NTFSHHSMVS 350 MLGKGFGDVG 360 EAKGGSTTGS 370 QFLEQFKTAQ 380 ALAQLAAQHS 390 QSGSTTTSSW 400 DMGSTTQSPS 410 LVQYDLKNPS 420 DSAVHSPFTK 430 RQAFTPSSTM 440 MEVFLQEKSP 450 AVATSTAAPP 460 PPSSPLPSKS 470 TSAPQMSPGS 480 SDNQSSSPQP 490 AQQKLKQQKK 500 KASLTSKIPA 510 LAVEMPGSAD 520 ISGLNLQFGA 530 LQFGSEPVLS 540 DYESTPTTSA 550 SSSQAPSSLY 560 TSTASESSST 570 ISSNQSQESG 580 YQSGPIQSTT 590 YTSQNNAQGP 600 LYEQRSTQTR 610 RYPSSISSSP 620 QKDLTQAKNG 630 FSSVQATQLQ 640 TTQSVEGATG 650 SAVKSDSPST 660 SSIPPLNETV 670 SAASLLTTTN 680 QHSSSLGGLS 690 HSEEIPNTTT 700 TQHSSTLSTQ 710 QNTLSSSTSS 720 GRTSTSTLLH 730 TSVESEANLH 740 SSSSTFSTTS 750 STVSAPPPVV 760 SVSSSLNSGS 770 SLGLSLGSNS 780 TVTASTRSSV 790 ATTSGKAPPN 800 LPPGVPPLLP 810 NPYIMAPGLL 820 HAYPPQVYGY 830 DDLQMLQTRF 840 PLDYYSIPFP 850 TPTTPLTGRD 860 GSLASNPYSG 870 DLTKFGRGDA 880 SSPAPATTLA 890 QPQQNQTQTH 900 HTTQQTFLNP 910 ALPPGYSYTS 920 LPYYTGVPGL 930 PSTFQYGPAV 940 FPVAPTSSKQ 950 HGVNVSVNAS 960 ATPFQQPSGY 970 GSHGYNTGVS 980 VTSSNTGVPD 990 ISGSVYSKTQ 1000 QSFEKQGFHS 1010 GTPAASFNLP 1020 SALGSGGPIN 1030 PATAAAYPPA 1040 PFMHILTPHQ 1050 QPHSQILHHH 1060 LQQDGQTGSG 1070 QRSQTSSIPQ 1080 KPQTNKSAYN SYSWGAN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005694 chromosome
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0010494 cytoplasmic stress granule
Cellular Component GO:0005634 nucleus
Cellular Component GO:0031519 PcG protein complex
Molecular Function GO:0003723 RNA binding
Biological Process GO:0007339 binding of sperm to zona pellucida
Biological Process GO:0061484 hematopoietic stem cell homeostasis
Biological Process GO:0062029 positive regulation of stress granule assembly
Biological Process GO:0034063 stress granule assembly

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.