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Overview

Uniprot IDQ14160
Protein NameProtein scribble homolog
Gene NameSCRIB
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
605 GRQRLIRKDTPHYKK

Function

Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:16965391, PubMed:18641685, PubMed:18716323, PubMed:19041750, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May regulate cell invasion via MAPK-mediated cell migration and adhesion (PubMed:18641685, PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity (PubMed:15182672)

Protein Sequence

10 MLKCIPLWRC 20 NRHVESVDKR 30 HCSLQAVPEE 40 IYRYSRSLEE 50 LLLDANQLRE 60 LPKPFFRLLN 70 LRKLGLSDNE 80 IQRLPPEVAN 90 FMQLVELDVS 100 RNDIPEIPES 110 IKFCKALEIA 120 DFSGNPLSRL 130 PDGFTQLRSL 140 AHLALNDVSL 150 QALPGDVGNL 160 ANLVTLELRE 170 NLLKSLPASL 180 SFLVKLEQLD 190 LGGNDLEVLP 200 DTLGALPNLR 210 ELWLDRNQLS 220 ALPPELGNLR 230 RLVCLDVSEN 240 RLEELPAELG 250 GLVLLTDLLL 260 SQNLLRRLPD 270 GIGQLKQLSI 280 LKVDQNRLCE 290 VTEAIGDCEN 300 LSELILTENL 310 LMALPRSLGK 320 LTKLTNLNVD 330 RNHLEALPPE 340 IGGCVALSVL 350 SLRDNRLAVL 360 PPELAHTTEL 370 HVLDVAGNRL 380 QSLPFALTHL 390 NLKALWLAEN 400 QAQPMLRFQT 410 EDDARTGEKV 420 LTCYLLPQQP 430 PPSLEDAGQQ 440 GSLSETWSDA 450 PPSRVSVIQF 460 LEAPIGDEDA 470 EEAAAEKRGL 480 QRRATPHPSE 490 LKVMKRSIEG 500 RRSEACPCQP 510 DSGSPLPAEE 520 EKRLSAESGL 530 SEDSRPSAST 540 VSEAEPEGPS 550 AEAQGGSQQE 560 ATTAGGEEDA 570 EEDYQEPTVH 580 FAEDALLPGD 590 DREIEEGQPE 600 APWTLPGGRQ 610 RLIRKDTPHY 620 KKHFKISKLP 630 QPEAVVALLQ 640 GMQPDGEGPV 650 APGGWHNGPH 660 APWAPRAQKE 670 EEEEEEGSPQ 680 EEEEEEEEEN 690 RAEEEEASTE 700 EEDKEGAVVS 710 APSVKGVSFD 720 QANNLLIEPA 730 RIEEEELTLT 740 ILRQTGGLGI 750 SIAGGKGSTP 760 YKGDDEGIFI 770 SRVSEEGPAA 780 RAGVRVGDKL 790 LEVNGVALQG 800 AEHHEAVEAL 810 RGAGTAVQMR 820 VWRERMVEPE 830 NAVTITPLRP 840 EDDYSPRERR 850 GGGLRLPLLP 860 PESPGPLRQR 870 HVACLARSER 880 GLGFSIAGGK 890 GSTPYRAGDA 900 GIFVSRIAEG 910 GAAHRAGTLQ 920 VGDRVLSING 930 VDVTEARHDH 940 AVSLLTAASP 950 TIALLLEREA 960 GGPLPPSPLP 970 HSSPPTAAVA 980 TTSITTATPG 990 VPGLPSLAPS 1000 LLAAALEGPY 1010 PVEEIRLPRA 1020 GGPLGLSIVG 1030 GSDHSSHPFG 1040 VQEPGVFISK 1050 VLPRGLAARS 1060 GLRVGDRILA 1070 VNGQDVRDAT 1080 HQEAVSALLR 1090 PCLELSLLVR 1100 RDPAPPGLRE 1110 LCIQKAPGER 1120 LGISIRGGAR 1130 GHAGNPRDPT 1140 DEGIFISKVS 1150 PTGAAGRDGR 1160 LRVGLRLLEV 1170 NQQSLLGLTH 1180 GEAVQLLRSV 1190 GDTLTVLVCD 1200 GFEASTDAAL 1210 EVSPGVIANP 1220 FAAGIGHRNS 1230 LESISSIDRE 1240 LSPEGPGKEK 1250 ELPGQTLHWG 1260 PEATEAAGRG 1270 LQPLKLDYRA 1280 LAAVPSAGSV 1290 QRVPSGAAGG 1300 KMAESPCSPS 1310 GQQPPSPPSP 1320 DELPANVKQA 1330 YRAFAAVPTS 1340 HPPEDAPAQP 1350 PTPGPAASPE 1360 QLSFRERQKY 1370 FELEVRVPQA 1380 EGPPKRVSLV 1390 GADDLRKMQE 1400 EEARKLQQKR 1410 AQMLREAAEA 1420 GAEARLALDG 1430 ETLGEEEQED 1440 EQPPWASPSP 1450 TSRQSPASPP 1460 PLGGGAPVRT 1470 AKAERRHQER 1480 LRVQSPEPPA 1490 PERALSPAEL 1500 RALEAEKRAL 1510 WRAARMKSLE 1520 QDALRAQMVL 1530 SRSQEGRGTR 1540 GPLERLAEAP 1550 SPAPTPSPTP 1560 VEDLGPQTST 1570 SPGRLPLSGK 1580 KFDYRAFAAL 1590 PSSRPVYDIQ 1600 SPDFAEELRS 1610 LEPSPSPGPQ 1620 EEDGEVALVL 1630 LGRPSPGAVG 1640 PEDVALCSSR 1650 RPVRPGRRGL GPVPS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0001772 immunological synapse
Cellular Component GO:0030027 lamellipodium
Cellular Component GO:0035748 myelin sheath abaxonal region
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0014069 postsynaptic density
Cellular Component GO:0098793 presynapse
Cellular Component GO:0034750 Scrib-APC-beta-catenin complex
Molecular Function GO:0045296 cadherin binding
Molecular Function GO:0019901 protein kinase binding
Molecular Function GO:0035591 signaling adaptor activity
Biological Process GO:0090630 activation of GTPase activity
Biological Process GO:0060561 apoptotic process involved in morphogenesis
Biological Process GO:0016477 cell migration
Biological Process GO:0008283 cell population proliferation
Biological Process GO:0098609 cell-cell adhesion
Biological Process GO:0010669 epithelial structure maintenance
Biological Process GO:0035089 establishment of apical/basal cell polarity
Biological Process GO:0001768 establishment of T cell polarity
Biological Process GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity
Biological Process GO:0060603 mammary gland duct morphogenesis
Biological Process GO:0046007 negative regulation of activated T cell proliferation
Biological Process GO:0045930 negative regulation of mitotic cell cycle
Biological Process GO:0001843 neural tube closure
Biological Process GO:0098887 neurotransmitter receptor transport, endosome to postsynaptic membrane
Biological Process GO:0030859 polarized epithelial cell differentiation
Biological Process GO:0050918 positive chemotaxis
Biological Process GO:0043065 positive regulation of apoptotic process
Biological Process GO:0001921 positive regulation of receptor recycling
Biological Process GO:0032729 positive regulation of type II interferon production
Biological Process GO:0071896 protein localization to adherens junction
Biological Process GO:0043113 receptor clustering
Biological Process GO:0048488 synaptic vesicle endocytosis
Biological Process GO:0016080 synaptic vesicle targeting
Cellular Component GO:0005912 adherens junction
Cellular Component GO:0016323 basolateral plasma membrane
Cellular Component GO:0030054 cell junction
Cellular Component GO:0044291 cell-cell contact zone
Cellular Component GO:0005911 cell-cell junction
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0070062 extracellular exosome

Reference

PMID: N/A