Overview
| Uniprot ID | Q14166 |
|---|
| Protein Name | Tubulin--tyrosine ligase-like protein 12 |
|---|
| Gene Name | TTLL12 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 88 |
EAAREVRKQQPNPGN |
Function
Negatively regulates post-translational modifications of tubulin, including detyrosination of the C-terminus and polyglutamylation of glutamate residues (PubMed:20162578, PubMed:23251473). Also, indirectly promotes histone H4 trimethylation at 'Lys-20' (H4K20me3) (PubMed:23251473). Probably by controlling tubulin and/or histone H4 post-translational modifications, plays a role in mitosis and in maintaining chromosome number stability (PubMed:20162578, PubMed:23251473). During RNA virus-mediated infection, acts as a negative regulator of the RIG-I pathway by preventing MAVS binding to TBK1 and IKBKE (PubMed:28011935)
Protein Sequence
10
MEAERGPERR
20
PAERSSPGQT
30
PEEGAQALAE
40
FAALHGPALR
50
ASGVPERYWG
60
RLLHKLEHEV
70
FDAGEVFGIM
80
QVEEVEEEED
90
EAAREVRKQQ
100
PNPGNELCYK
110
VIVTRESGLQ
120
AAHPNSIFLI
130
DHAWTCRVEH
140
ARQQLQQVPG
150
LLHRMANLMG
160
IEFHGELPST
170
EAVALVLEEM
180
WKFNQTYQLA
190
HGTAEEKMPV
200
WYIMDEFGSR
210
IQHADVPSFA
220
TAPFFYMPQQ
230
VAYTLLWPLR
240
DLDTGEEVTR
250
DFAYGETDPL
260
IRKCMLLPWA
270
PTDMLDLSSC
280
TPEPPAEHYQ
290
AILEENKEKL
300
PLDINPVVHP
310
HGHIFKVYTD
320
VQQVASSLTH
330
PRFTLTQSEA
340
DADILFNFSH
350
FKDYRKLSQE
360
RPGVLLNQFP
370
CENLLTVKDC
380
LASIARRAGG
390
PEGPPWLPRT
400
FNLRTELPQF
410
VSYFQQRERW
420
GEDNHWICKP
430
WNLARSLDTH
440
VTKSLHSIIR
450
HRESTPKVVS
460
KYIESPVLFL
470
REDVGKVKFD
480
IRYIVLLRSV
490
RPLRLFVYDV
500
FWLRFSNRAF
510
ALNDLDDYEK
520
HFTVMNYDPD
530
VVLKQVHCEE
540
FIPEFEKQYP
550
EFPWTDVQAE
560
IFRAFTELFQ
570
VACAKPPPLG
580
LCDYPSSRAM
590
YAVDLMLKWD
600
NGPDGRRVMQ
610
PQILEVNFNP
620
DCERACRYHP
630
TFFNDVFSTL
640
FLDQPGGCHV
TCLV
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005813 |
centrosome |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0030496 |
midbody |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005819 |
spindle |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0140005 |
histone H4K20me2 reader activity |
| Biological Process |
GO:0045087 |
innate immune response |
| Biological Process |
GO:0060339 |
negative regulation of type I interferon-mediated signaling pathway |
| Biological Process |
GO:0007346 |
regulation of mitotic cell cycle |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.