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Overview

Uniprot IDQ14185
Protein NameDedicator of cytokinesis protein 1
Gene NameDOCK1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1705 KKEKRNSKHQEIFEK

Function

Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829). Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1 (PubMed:8657152)

Protein Sequence

10 MTRWVPTKRE 20 EKYGVAFYNY 30 DARGADELSL 40 QIGDTVHILE 50 TYEGWYRGYT 60 LRKKSKKGIF 70 PASYIHLKEA 80 IVEGKGQHET 90 VIPGDLPLIQ 100 EVTTTLREWS 110 TIWRQLYVQD 120 NREMFRSVRH 130 MIYDLIEWRS 140 QILSGTLPQD 150 ELKELKKKVT 160 AKIDYGNRIL 170 DLDLVVRDED 180 GNILDPELTS 190 TISLFRAHEI 200 ASKQVEERLQ 210 EEKSQKQNID 220 INRQAKFAAT 230 PSLALFVNLK 240 NVVCKIGEDA 250 EVLMSLYDPV 260 ESKFISENYL 270 VRWSSSGLPK 280 DIDRLHNLRA 290 VFTDLGSKDL 300 KREKISFVCQ 310 IVRVGRMELR 320 DNNTRKLTSG 330 LRRPFGVAVM 340 DVTDIINGKV 350 DDEDKQHFIP 360 FQPVAGENDF 370 LQTVINKVIA 380 AKEVNHKGQG 390 LWVTLKLLPG 400 DIHQIRKEFP 410 HLVDRTTAVA 420 RKTGFPEIIM 430 PGDVRNDIYV 440 TLVQGDFDKG 450 SKTTAKNVEV 460 TVSVYDEDGK 470 RLEHVIFPGA 480 GDEAISEYKS 490 VIYYQVKQPR 500 WFETVKVAIP 510 IEDVNRSHLR 520 FTFRHRSSQD 530 SKDKSEKIFA 540 LAFVKLMRYD 550 GTTLRDGEHD 560 LIVYKAEAKK 570 LEDAATYLSL 580 PSTKAELEEK 590 GHSATGKSMQ 600 SLGSCTISKD 610 SFQISTLVCS 620 TKLTQNVDLL 630 GLLKWRSNTS 640 LLQQNLRQLM 650 KVDGGEVVKF 660 LQDTLDALFN 670 IMMENSESET 680 FDTLVFDALV 690 FIIGLIADRK 700 FQHFNPVLET 710 YIKKHFSATL 720 AYTKLTKVLK 730 NYVDGAEKPG 740 VNEQLYKAMK 750 ALESIFKFIV 760 RSRILFNQLY 770 ENKGEADFVE 780 SLLQLFRSIN 790 DMMSSMSDQT 800 VRVKGAALKY 810 LPTIVNDVKL 820 VFDPKELSKM 830 FTEFILNVPM 840 GLLTIQKLYC 850 LIEIVHSDLF 860 TQHDCREILL 870 PMMTDQLKYH 880 LERQEDLEAC 890 CQLLSHILEV 900 LYRKDVGPTQ 910 RHVQIIMEKL 920 LRTVNRTVIS 930 MGRDSELIGN 940 FVACMTAILR 950 QMEDYHYAHL 960 IKTFGKMRTD 970 VVDFLMETFI 980 MFKNLIGKNV 990 YPFDWVIMNM 1000 VQNKVFLRAI 1010 NQYADMLNKK 1020 FLDQANFELQ 1030 LWNNYFHLAV 1040 AFLTQESLQL 1050 ENFSSAKRAK 1060 ILNKYGDMRR 1070 QIGFEIRDMW 1080 YNLGQHKIKF 1090 IPEMVGPILE 1100 MTLIPETELR 1110 KATIPIFFDM 1120 MQCEFHSTRS 1130 FQMFENEIIT 1140 KLDHEVEGGR 1150 GDEQYKVLFD 1160 KILLEHCRKH 1170 KYLAKTGETF 1180 VKLVVRLMER 1190 LLDYRTIMHD 1200 ENKENRMSCT 1210 VNVLNFYKEI 1220 EREEMYIRYL 1230 YKLCDLHKEC 1240 DNYTEAAYTL 1250 LLHAKLLKWS 1260 EDVCVAHLTQ 1270 RDGYQATTQG 1280 QLKEQLYQEI 1290 IHYFDKGKMW 1300 EEAIALGKEL 1310 AEQYENEMFD 1320 YEQLSELLKK 1330 QAQFYENIVK 1340 VIRPKPDYFA 1350 VGYYGQGFPT 1360 FLRGKVFIYR 1370 GKEYERREDF 1380 EARLLTQFPN 1390 AEKMKTTSPP 1400 GDDIKNSPGQ 1410 YIQCFTVKPK 1420 LDLPPKFHRP 1430 VSEQIVSFYR 1440 VNEVQRFEYS 1450 RPIRKGEKNP 1460 DNEFANMWIE 1470 RTIYTTAYKL 1480 PGILRWFEVK 1490 SVFMVEISPL 1500 ENAIETMQLT 1510 NDKINSMVQQ 1520 HLDDPSLPIN 1530 PLSMLLNGIV 1540 DPAVMGGFAN 1550 YEKAFFTDRY 1560 LQEHPEAHEK 1570 IEKLKDLIAW 1580 QIPFLAEGIR 1590 IHGDKVTEAL 1600 RPFHERMEAC 1610 FKQLKEKVEK 1620 EYGVRIMPSS 1630 LDDRRGSRPR 1640 SMVRSFTMPS 1650 SSRPLSVASV 1660 SSLSSDSTPS 1670 RPGSDGFALE 1680 PLLPKKMHSR 1690 SQDKLDKDDL 1700 EKEKKDKKKE 1710 KRNSKHQEIF 1720 EKEFKPTDIS 1730 LQQSEAVILS 1740 ETISPLRPQR 1750 PKSQVMNVIG 1760 SERRFSVSPS 1770 SPSSQQTPPP 1780 VTPRAKLSFS 1790 MQSSLELNGM 1800 TGADVADVPP 1810 PLPLKGSVAD 1820 YGNLMENQDL 1830 LGSPTPPPPP 1840 PHQRHLPPPL 1850 PSKTPPPPPP 1860 KTTRKQASVD SGIVQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0098978 glutamatergic synapse
Cellular Component GO:0032045 guanyl-nucleotide exchange factor complex
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0098794 postsynapse
Molecular Function GO:0005096 GTPase activator activity
Molecular Function GO:0005085 guanyl-nucleotide exchange factor activity
Molecular Function GO:0017124 SH3 domain binding
Molecular Function GO:0031267 small GTPase binding
Biological Process GO:0006915 apoptotic process
Biological Process GO:0016477 cell migration
Biological Process GO:0007229 integrin-mediated signaling pathway
Biological Process GO:0007520 myoblast fusion
Biological Process GO:0006911 phagocytosis, engulfment
Biological Process GO:0010634 positive regulation of epithelial cell migration
Biological Process GO:1900026 positive regulation of substrate adhesion-dependent cell spreading
Biological Process GO:0150052 regulation of postsynapse assembly
Biological Process GO:0007165 signal transduction
Biological Process GO:0007264 small GTPase-mediated signal transduction

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.